Strain Name:
C57BL/6J-MtgxR5759Btlr
Stock Number:
043361-MU
Citation ID:
RRID:MMRRC_043361-MU
Other Names:
R5759 (G1)
Major Collection:

Gene Information

Slc35a1
Name: solute carrier family 35 (CMP-sialic acid transporter), member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 24060
Homologene: 38181
Chst5
Name: carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
Synonyms: I-GlcNAc6ST, GST-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 56773
Homologene: 56927
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: P1, p1.m, Mcmd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Exoc6
Name: exocyst complex component 6
Synonyms: Sec15l1, Sec15, msec15, 4833405E05Rik, hbd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107371
VEGA: 19
Homologene: 41305
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Mmp20
Name: matrix metallopeptidase 20 (enamelysin)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 30800
VEGA: 9
HGNC: HGNC:7167
Homologene: 21001
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Minar1
Name: membrane integral NOTCH2 associated receptor 1
Synonyms: AF529169, DD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 209743
Homologene: 17782
Mfsd5
Name: major facilitator superfamily domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 106073
VEGA: 15
Homologene: 69517
Sept9
Name: septin 9
Synonyms: MSF1, Sint1, SL3-3 integration site 1, PNUTL4, Msf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 53860
HGNC: HGNC:7323
Homologene: 90949
Tcf25
Name: transcription factor 25 (basic helix-loop-helix)
Synonyms: 1100001J13Rik, Nulp1, D8Ertd325e, 1810041K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 66855
Homologene: 5701
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 5430439G14Rik, 6330406J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71389
Homologene: 32772
Ndfip2
Name: Nedd4 family interacting protein 2
Synonyms: N4wbp5a, 0710001O20Rik, 9130207N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 76273
Homologene: 12636
Zfp445
Name: zinc finger protein 445
Synonyms: ZNF168
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235682
VEGA: 9
Homologene: 27832
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: 9930021N24Rik, Myst3, MOZ, Zfp220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244349
Homologene: 4924
Fam13b
Name: family with sequence similarity 13, member B
Synonyms: 2610024E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225358
VEGA: 18
HGNC: HGNC:1335
Homologene: 9585
Zfp599
Name: zinc finger protein 599
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235048
HGNC: null
Homologene: 138456
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Piezo1, Fam38a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234839
Homologene: 124356
Emp2
Name: epithelial membrane protein 2
Synonyms: Xmp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13731
HGNC: HGNC:3334
Homologene: 1089
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233651
Homologene: 2771
Olfr905
Name: olfactory receptor 905
Synonyms: GA_x6K02T2PVTD-32165709-32166641, MOR167-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258800
VEGA: 9
HGNC: null
Homologene: 110524
Sntg1
Name: syntrophin, gamma 1
Synonyms: SYN4, G1SYN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 71096
Homologene: 56834
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
1110002E22Rik
Name: RIKEN cDNA 1110002E22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 102634333
Homologene: 131709
Trim34b
Name: tripartite motif-containing 34B
Synonyms: Gm15134, Trim34-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434218
Homologene: 128238
Ifi30
Name: interferon gamma inducible protein 30
Synonyms: lysosomal thio reductase IP30 precursor, GILT, IP30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 65972
VEGA: 8
HGNC: HGNC:5398
Homologene: 38171
Olfr869
Name: olfactory receptor 869
Synonyms: MOR145-6, GA_x6K02T2PVTD-13878275-13879204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258550
HGNC: null
Homologene: 138312
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231470
Homologene: 23516
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: 6430542K11Rik, Glu5R, Gprc1e, mGluR5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Phf19
Name: PHD finger protein 19
Synonyms: 3110009G19Rik, 3321402G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 74016
Homologene: 12524
Adamts1
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
Synonyms: METH-1, METH1, ADAM-TS1, ADAMTS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227058
Homologene: 41287
Olfr862
Name: olfactory receptor 862
Synonyms: GA_x6K02T2PVTD-13624132-13623212, MOR146-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258555
HGNC: null
Homologene: 115540
Mybphl
Name: myosin binding protein H-like
Synonyms: 1110037P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 68753
Homologene: 19221
Hhatl
Name: hedgehog acyltransferase-like
Synonyms: 1110011D13Rik, Gup1, Mitsugumin 56, Mg56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74770
VEGA: 9
Homologene: 19287
Tnk2
Name: tyrosine kinase, non-receptor, 2
Synonyms: activated p21cdc42Hs kinase, ACK1, P21cdc42Hs kinase, Pyk1, Ack
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 51789
Homologene: 4224
Ing2
Name: inhibitor of growth family, member 2
Synonyms: P33ING2, 2810011M06Rik, ING2, Ing1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 69260
HGNC: HGNC:6063
Homologene: 20388
Tchhl1
Name: trichohyalin-like 1
Synonyms: Thhl1, S100a17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71325
Homologene: 84625
Fam186b
Name: family with sequence similarity 186, member B
Synonyms: EG545136
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 545136
VEGA: 15
Homologene: 69502
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434117
HGNC: null
Homologene: 113703
Tmem106b
Name: transmembrane protein 106B
Synonyms: 2310036D22Rik, 5830455K21Rik, 6430519M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 71900
Homologene: 56806
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100101919
Homologene: 41287
Gm14409
Name: predicted gene 14409
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: null
HGNC: null
Homologene: null
Arf2
Name: ADP-ribosylation factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11841
Homologene: 56086
Trib1
Name: tribbles pseudokinase 1
Synonyms: A530090O15Rik, Trb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 211770
Homologene: 75216
Trib3
Name: tribbles pseudokinase 3
Synonyms: Nipk, Ifld2, SKIP3, Trb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228775
Homologene: 10902
BC100451
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 8,414,270 bp
  • CT to CTT, chromosome 1 at 20,808,748 bp
  • A to G, chromosome 1 at 46,277,120 bp
  • G to A, chromosome 1 at 46,615,367 bp
  • T to G, chromosome 2 at 34,897,123 bp
  • T to C, chromosome 2 at 91,162,075 bp
  • A to T, chromosome 2 at 152,343,295 bp
  • C to T, chromosome 2 at 160,983,762 bp
  • A to T, chromosome 2 at 177,264,972 bp
  • C to G, chromosome 3 at 93,471,556 bp
  • T to C, chromosome 3 at 108,374,754 bp
  • T to C, chromosome 3 at 138,068,658 bp
  • C to A, chromosome 4 at 34,675,032 bp
  • T to C, chromosome 5 at 96,709,916 bp
  • A to G, chromosome 6 at 13,075,042 bp
  • A to G, chromosome 7 at 10,047,978 bp
  • A to C, chromosome 7 at 88,026,600 bp
  • T to C, chromosome 7 at 104,331,433 bp
  • T to A, chromosome 7 at 105,764,176 bp
  • T to G, chromosome 8 at 22,938,012 bp
  • G to T, chromosome 8 at 47,669,005 bp
  • A to G, chromosome 8 at 70,766,544 bp
  • C to A, chromosome 8 at 111,890,210 bp
  • A to G, chromosome 8 at 122,507,655 bp
  • A to G, chromosome 8 at 123,381,457 bp
  • T to A, chromosome 9 at 7,628,377 bp
  • A to G, chromosome 9 at 19,884,188 bp
  • T to A, chromosome 9 at 20,137,932 bp
  • T to C, chromosome 9 at 22,249,661 bp
  • T to A, chromosome 9 at 38,473,535 bp
  • T to C, chromosome 9 at 54,375,508 bp
  • A to T, chromosome 9 at 89,601,072 bp
  • A to G, chromosome 9 at 95,874,402 bp
  • A to G, chromosome 9 at 121,788,277 bp
  • G to T, chromosome 9 at 122,853,146 bp
  • G to A, chromosome 11 at 103,983,633 bp
  • A to G, chromosome 11 at 117,352,268 bp
  • T to C, chromosome 11 at 118,333,646 bp
  • T to A, chromosome 14 at 105,302,316 bp
  • G to A, chromosome 15 at 59,654,501 bp
  • T to G, chromosome 15 at 99,279,717 bp
  • G to A, chromosome 15 at 102,281,078 bp
  • T to A, chromosome 16 at 10,284,510 bp
  • C to T, chromosome 16 at 32,680,664 bp
  • A to G, chromosome 16 at 85,798,048 bp
  • T to C, chromosome 18 at 34,497,435 bp
  • C to T, chromosome 19 at 37,573,741 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5759 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043361-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.