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Strain Name:
C57BL/6J-MtgxR5936Btlr/Mmmh
Stock Number:
044130-MU
Citation ID:
RRID:MMRRC_044130-MU
Other Names:
R5936 (G1)
Major Collection:

Strain Information

Pdpk1
Name: 3-phosphoinositide dependent protein kinase 1
Synonyms: Pkb kinase, Pdk1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18607
Homologene: 37643
Ptch2
Name: patched 2
Synonyms: ptc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19207
HGNC: HGNC:9586
Homologene: 37842
Etv1
Name: ets variant 1
Synonyms: ER81, Etsrp81
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Rtn4rl2
Name: reticulon 4 receptor-like 2
Synonyms: Ngr2, Ngrh1, Ngrl3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269295
Homologene: 18683
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Orc1
Name: origin recognition complex, subunit 1
Synonyms: MmORC1, Orc1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18392
HGNC: HGNC:8487
Homologene: 31221
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 9,885,820 bp
  • G to T, chromosome 1 at 34,307,458 bp
  • T to G, chromosome 1 at 163,987,012 bp
  • A to G, chromosome 2 at 30,107,667 bp
  • G to T, chromosome 2 at 38,701,778 bp
  • A to T, chromosome 2 at 68,615,504 bp
  • A to T, chromosome 2 at 79,756,454 bp
  • A to T, chromosome 2 at 84,880,431 bp
  • T to A, chromosome 2 at 112,021,587 bp
  • A to G, chromosome 2 at 181,230,767 bp
  • C to A, chromosome 3 at 105,680,587 bp
  • A to G, chromosome 3 at 109,098,638 bp
  • A to G, chromosome 3 at 127,562,253 bp
  • C to T, chromosome 4 at 6,421,017 bp
  • T to C, chromosome 4 at 49,383,362 bp
  • A to G, chromosome 4 at 108,601,983 bp
  • C to T, chromosome 4 at 113,096,593 bp
  • T to G, chromosome 4 at 117,108,294 bp
  • A to T, chromosome 5 at 34,224,988 bp
  • A to G, chromosome 5 at 35,502,643 bp
  • A to G, chromosome 5 at 35,974,396 bp
  • A to G, chromosome 5 at 64,822,960 bp
  • A to G, chromosome 5 at 107,359,395 bp
  • G to A, chromosome 5 at 112,385,757 bp
  • T to C, chromosome 5 at 128,751,078 bp
  • A to G, chromosome 5 at 137,587,006 bp
  • A to T, chromosome 6 at 57,114,317 bp
  • A to G, chromosome 6 at 91,987,911 bp
  • T to A, chromosome 6 at 129,538,603 bp
  • T to C, chromosome 7 at 28,086,692 bp
  • T to A, chromosome 7 at 66,172,277 bp
  • T to C, chromosome 7 at 101,191,701 bp
  • T to A, chromosome 7 at 140,922,812 bp
  • C to A, chromosome 8 at 15,027,534 bp
  • T to A, chromosome 9 at 73,578,492 bp
  • T to C, chromosome 9 at 75,009,304 bp
  • C to T, chromosome 9 at 86,372,459 bp
  • T to A, chromosome 9 at 86,536,512 bp
  • T to C, chromosome 9 at 107,289,170 bp
  • A to G, chromosome 10 at 20,965,933 bp
  • C to T, chromosome 10 at 52,346,199 bp
  • T to A, chromosome 10 at 92,962,412 bp
  • G to A, chromosome 10 at 127,471,812 bp
  • T to A, chromosome 10 at 128,848,771 bp
  • A to G, chromosome 11 at 4,904,133 bp
  • T to A, chromosome 11 at 7,209,472 bp
  • A to G, chromosome 11 at 77,818,213 bp
  • G to T, chromosome 11 at 84,825,524 bp
  • C to T, chromosome 11 at 103,078,347 bp
  • T to C, chromosome 12 at 31,937,096 bp
  • C to A, chromosome 12 at 38,835,210 bp
  • G to T, chromosome 12 at 98,489,932 bp
  • T to G, chromosome 13 at 27,388,449 bp
  • A to G, chromosome 14 at 30,171,314 bp
  • A to T, chromosome 14 at 57,643,499 bp
  • G to T, chromosome 14 at 86,772,116 bp
  • A to T, chromosome 15 at 6,784,161 bp
  • T to C, chromosome 15 at 36,479,282 bp
  • C to A, chromosome 15 at 59,330,829 bp
  • T to A, chromosome 15 at 66,000,110 bp
  • A to G, chromosome 15 at 90,935,647 bp
  • T to A, chromosome 15 at 95,972,601 bp
  • T to A, chromosome 15 at 97,385,180 bp
  • T to A, chromosome 15 at 97,385,182 bp
  • A to G, chromosome 17 at 24,093,229 bp
  • A to C, chromosome 17 at 24,216,341 bp
  • A to T, chromosome 17 at 27,704,997 bp
  • A to T, chromosome 17 at 28,165,487 bp
  • T to C, chromosome 17 at 31,625,094 bp
  • A to T, chromosome 17 at 63,924,063 bp
  • A to T, chromosome 18 at 20,874,688 bp
  • A to T, chromosome 18 at 61,125,808 bp
  • G to A, chromosome 18 at 65,350,520 bp
  • A to G, chromosome 19 at 3,884,580 bp
  • A to C, chromosome 19 at 40,324,772 bp
  • A to G, chromosome 19 at 42,323,837 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5936 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044130-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.