Strain Name:
C57BL/6J-MtgxR5963Btlr
Stock Number:
044148-MU
Citation ID:
RRID:MMRRC_044148-MU
Other Names:
R5963 (G1)
Major Collection:

Gene Information

Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20564
Homologene: 2303
Pnn
Name: pinin
Synonyms: D12Ertd512e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18949
VEGA: 12
HGNC: HGNC:9162
Homologene: 37656
Rad54l
Name: RAD54 like (S. cerevisiae)
Synonyms: RAD54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19366
HGNC: HGNC:9826
Homologene: 48227
Mapkapk5
Name: MAP kinase-activated protein kinase 5
Synonyms: PRAK, MK5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17165
HGNC: HGNC:6889
Homologene: 69077
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: 4732474L06Rik, Jmjd2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 193796
Homologene: 27773
Btbd9
Name: BTB (POZ) domain containing 9
Synonyms: 1700023F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224671
VEGA: 17
Homologene: 14995
Rttn
Name: rotatin
Synonyms: 4921538A15Rik, C530033I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: RIM2, 2810036I15Rik, Syt3-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 116838
VEGA: 15
Homologene: 81639
Aqr
Name: aquarius
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11834
Homologene: 7629
Garem1
Name: GRB2 associated regulator of MAPK1 subtype 1
Synonyms: LOC381126, Fam59a, Garem
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381126
VEGA: 18
Homologene: 11237
Ccdc138
Name: coiled-coil domain containing 138
Synonyms: 6230424H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76138
VEGA: 10
Homologene: 44912
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209018
Homologene: 44592
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 386750
Homologene: 8955
Fcrl5
Name: Fc receptor-like 5
Synonyms: BXMAS1-like protein 2, Fcrh3, mBXMH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329693
Homologene: 137404
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana-2, Mana2, Map-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
St14
Name: suppression of tumorigenicity 14 (colon carcinoma)
Synonyms: Prss14, Epithin, MT-SP1, matriptase, Tmprss14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19143
Homologene: 7906
Zmynd11
Name: zinc finger, MYND domain containing 11
Synonyms: 2210402G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66505
Homologene: 4828
Vps51
Name: VPS51 GARP complex subunit
Synonyms: 3110057M17Rik, 1110014N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68505
HGNC: HGNC:1172
Homologene: 34675
Alg8
Name: asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase)
Synonyms: LOC381903
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381903
Homologene: 6931
Trerf1
Name: transcriptional regulating factor 1
Synonyms: Trep132, Trep-132, 9430096I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224829
Homologene: 14129
Slc9a2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 2
Synonyms: NHE2, 4932415O19Rik, 2210416H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226999
Homologene: 20661
Septin5
Name: septin 5
Synonyms: Cdcrel1, Pnutl1, Sept5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 18951
VEGA: 16
HGNC: HGNC:9164
Homologene: 74446
Pdcd2
Name: programmed cell death 2
Synonyms: RP-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18567
HGNC: HGNC:8762
Homologene: 1951
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 546144
Homologene: 52326
Primpol
Name: primase and polymerase (DNA-directed)
Synonyms: Ccdc111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 408022
Homologene: 14065
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212124
Bmper
Name: BMP-binding endothelial regulator
Synonyms: Cv2, 3110056H04Rik, CV-2, Crim3, crossveinless-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 73230
VEGA: 9
Homologene: 12494
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Zcchc14
Name: zinc finger, CCHC domain containing 14
Synonyms: Bdg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 142682
Homologene: 9037
Ints11
Name: integrator complex subunit 11
Synonyms: 2410006F12Rik, Cpsf3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71957
Homologene: 9894
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241589
Homologene: 115928
Pcdha1
Name: protocadherin alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 116731
HGNC: HGNC:8663
Homologene: 75093
Lipn
Name: lipase, family member N
Synonyms: 2210418G03Rik, Lipl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 70166
Homologene: 66969
Gpr87
Name: G protein-coupled receptor 87
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 84111
HGNC: HGNC:4538
Homologene: 13021
Gsdmc
Name: gasdermin C
Synonyms: Mlze, Gsdmc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 83492
HGNC: HGNC:7151
Homologene: 69487
C5ar1
Name: complement component 5a receptor 1
Synonyms: C5aR, Cd88, C5r1, D7Msu1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12273
HGNC: HGNC:1338
Homologene: 20413
Ybx2
Name: Y box protein 2
Synonyms: MSY2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53422
Homologene: 22942
Simc1
Name: SUMO-interacting motifs containing 1
Synonyms: 4732471D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319719
Homologene: 131217
Mog
Name: myelin oligodendrocyte glycoprotein
Synonyms: B230317G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17441
HGNC: HGNC:7197
Homologene: 111009
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4930428C11Rik, 4632415N18Rik, 4930463G05Rik, D19Ertd652e, Wdr96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100048534
Homologene: 36425
Slc15a5
Name: solute carrier family 15, member 5
Synonyms: 9830102E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 277898
Homologene: 65333
Cherp
Name: calcium homeostasis endoplasmic reticulum protein
Synonyms: SCAF6, DAN16, D8Wsu96e, 5730408I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 27967
Homologene: 4656
Vegfc
Name: vascular endothelial growth factor C
Synonyms: VEGF-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22341
Homologene: 3962
Nom1
Name: nucleolar protein with MIF4G domain 1
Synonyms: LOC381627, D5Kng1, Gm1040
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 433864
Homologene: 39776
Zfp84
Name: zinc finger protein 84
Synonyms: C86188, Zfp69, KRAB18, 4633401C23Rik, 2210410P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74352
Homologene: 51858
Olfr65
Name: olfactory receptor 65
Synonyms: 5'[b]3, MOR1-2, GA_x6K02T2PBJ9-6634906-6633983
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18365
Homologene: 66459
Traf5
Name: TNF receptor-associated factor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22033
Homologene: 27079
Tnnt2
Name: troponin T2, cardiac
Synonyms: Tnt, cTnT, cardiac TnT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21956
Homologene: 68050
Bbs2
Name: Bardet-Biedl syndrome 2 (human)
Synonyms: 2410125H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67378
HGNC: HGNC:967
Homologene: 12122
Mrps24
Name: mitochondrial ribosomal protein S24
Synonyms: Rpms24, 3110030K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 64660
Homologene: 57043
Pla2g12b
Name: phospholipase A2, group XIIB
Synonyms: 2010002E04Rik, Pla2g13, hlb218
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69836
Homologene: 11356
Vmn1r65
Name: vomeronasal 1 receptor 65
Synonyms: V3R6, V1rd6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81013
Homologene: 110799
Zfp383
Name: zinc finger protein 383
Synonyms: 1110003H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73729
Homologene: 128413
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 40,682,036 bp
  • T to C, chromosome 1 at 135,843,862 bp
  • G to A, chromosome 1 at 192,000,016 bp
  • C to T, chromosome 2 at 104,248,285 bp
  • T to C, chromosome 2 at 114,126,961 bp
  • A to C, chromosome 3 at 39,010,547 bp
  • T to A, chromosome 3 at 59,179,269 bp
  • A to G, chromosome 3 at 73,050,713 bp
  • T to C, chromosome 3 at 87,444,173 bp
  • A to T, chromosome 4 at 116,110,387 bp
  • T to A, chromosome 4 at 155,872,912 bp
  • T to C, chromosome 5 at 29,437,770 bp
  • G to T, chromosome 5 at 121,538,481 bp
  • A to G, chromosome 6 at 138,079,693 bp
  • T to A, chromosome 7 at 6,008,609 bp
  • A to G, chromosome 7 at 16,248,822 bp
  • G to T, chromosome 7 at 29,776,953 bp
  • A to G, chromosome 7 at 29,915,678 bp
  • A to G, chromosome 7 at 97,379,830 bp
  • T to A, chromosome 7 at 103,906,961 bp
  • T to A, chromosome 7 at 139,651,595 bp
  • T to A, chromosome 8 at 46,593,580 bp
  • A to G, chromosome 8 at 54,181,284 bp
  • G to T, chromosome 8 at 72,461,535 bp
  • A to T, chromosome 8 at 94,081,031 bp
  • T to A, chromosome 8 at 110,494,294 bp
  • A to T, chromosome 8 at 121,628,623 bp
  • T to A, chromosome 9 at 23,375,593 bp
  • A to T, chromosome 9 at 31,106,557 bp
  • T to C, chromosome 9 at 74,145,028 bp
  • A to G, chromosome 10 at 58,575,757 bp
  • T to A, chromosome 10 at 59,403,958 bp
  • T to A, chromosome 10 at 69,987,226 bp
  • A to T, chromosome 11 at 5,707,481 bp
  • C to T, chromosome 11 at 35,700,236 bp
  • A to G, chromosome 11 at 69,941,092 bp
  • C to T, chromosome 12 at 59,067,831 bp
  • G to T, chromosome 13 at 9,695,895 bp
  • T to A, chromosome 13 at 54,525,819 bp
  • A to T, chromosome 15 at 39,437,182 bp
  • A to T, chromosome 15 at 63,780,116 bp
  • T to C, chromosome 16 at 18,624,212 bp
  • T to C, chromosome 16 at 21,470,121 bp
  • T to C, chromosome 17 at 15,526,394 bp
  • G to T, chromosome 17 at 15,526,395 bp
  • C to T, chromosome 17 at 30,334,218 bp
  • G to A, chromosome 17 at 37,012,348 bp
  • C to T, chromosome 17 at 47,314,337 bp
  • A to T, chromosome 17 at 56,399,732 bp
  • T to G, chromosome 17 at 64,675,122 bp
  • T to A, chromosome 18 at 21,129,430 bp
  • T to A, chromosome 18 at 36,931,171 bp
  • T to C, chromosome 18 at 89,073,695 bp
  • A to G, chromosome 19 at 6,068,290 bp
  • A to G, chromosome 19 at 34,081,300 bp
  • A to T, chromosome 19 at 47,745,574 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5963 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044148-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.