Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR6041Btlr/Mmmh
Stock Number:
044209-MU
Citation ID:
RRID:MMRRC_044209-MU
Other Names:
R6041 (G1)
Major Collection:

Strain Information

Pax6
Name: paired box 6
Synonyms: Pax-6, Dey, Dickie's small eye, 1500038E17Rik, AEY11, Gsfaey11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18508
HGNC: HGNC:8620
Homologene: 1212
Psen2
Name: presenilin 2
Synonyms: ALG-3, PS-2, PS2, Ad4h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19165
HGNC: HGNC:9509
Homologene: 386
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: 2510010B09Rik, D10Ertd17e, Cxxc6, BB001228
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Npy5r
Name: neuropeptide Y receptor Y5
Synonyms: Y5R
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18168
HGNC: HGNC:7958
Homologene: 21241
Scrib
Name: scribbled planar cell polarity
Synonyms: Scrb1, Crc
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 46,289,645 bp
  • C to A, chromosome 1 at 180,245,727 bp
  • G to A, chromosome 2 at 85,923,391 bp
  • A to T, chromosome 2 at 90,808,027 bp
  • A to G, chromosome 2 at 105,683,902 bp
  • T to A, chromosome 3 at 41,627,177 bp
  • T to C, chromosome 3 at 79,069,162 bp
  • A to C, chromosome 3 at 88,396,051 bp
  • T to A, chromosome 3 at 93,220,361 bp
  • A to T, chromosome 3 at 94,317,499 bp
  • C to A, chromosome 4 at 60,088,549 bp
  • A to C, chromosome 4 at 116,962,621 bp
  • T to A, chromosome 4 at 123,513,848 bp
  • T to C, chromosome 5 at 6,771,231 bp
  • T to G, chromosome 5 at 110,047,573 bp
  • A to T, chromosome 5 at 122,351,352 bp
  • A to G, chromosome 6 at 87,434,320 bp
  • A to C, chromosome 6 at 141,739,038 bp
  • T to C, chromosome 7 at 4,145,569 bp
  • C to A, chromosome 7 at 7,278,184 bp
  • A to T, chromosome 7 at 26,759,427 bp
  • T to C, chromosome 7 at 66,262,133 bp
  • A to T, chromosome 7 at 140,812,245 bp
  • A to T, chromosome 8 at 66,682,023 bp
  • A to T, chromosome 8 at 123,200,655 bp
  • A to G, chromosome 9 at 50,344,782 bp
  • A to G, chromosome 9 at 54,416,753 bp
  • A to G, chromosome 9 at 59,563,236 bp
  • C to T, chromosome 9 at 110,084,598 bp
  • A to G, chromosome 9 at 111,377,796 bp
  • A to G, chromosome 9 at 119,609,469 bp
  • A to T, chromosome 9 at 121,460,412 bp
  • G to T, chromosome 10 at 62,813,373 bp
  • T to C, chromosome 10 at 75,893,501 bp
  • A to G, chromosome 10 at 79,913,661 bp
  • A to G, chromosome 11 at 60,779,568 bp
  • A to T, chromosome 11 at 67,364,730 bp
  • T to G, chromosome 11 at 98,828,559 bp
  • A to C, chromosome 11 at 105,975,308 bp
  • A to T, chromosome 11 at 114,806,377 bp
  • T to A, chromosome 12 at 82,342,250 bp
  • A to G, chromosome 12 at 104,781,872 bp
  • A to C, chromosome 12 at 116,142,984 bp
  • T to A, chromosome 13 at 52,919,086 bp
  • T to A, chromosome 13 at 95,701,109 bp
  • T to A, chromosome 13 at 97,172,623 bp
  • T to C, chromosome 13 at 100,617,766 bp
  • A to T, chromosome 14 at 30,042,357 bp
  • T to C, chromosome 14 at 33,956,482 bp
  • C to T, chromosome 14 at 78,587,627 bp
  • T to A, chromosome 15 at 8,324,264 bp
  • C to T, chromosome 15 at 76,067,172 bp
  • C to T, chromosome 15 at 98,058,216 bp
  • C to A, chromosome 15 at 102,717,939 bp
  • A to G, chromosome 16 at 17,360,572 bp
  • A to T, chromosome 16 at 22,868,721 bp
  • T to G, chromosome 16 at 57,173,150 bp
  • T to A, chromosome 17 at 24,376,380 bp
  • T to A, chromosome 17 at 56,419,080 bp
  • A to T, chromosome 17 at 88,985,986 bp
  • A to T, chromosome 18 at 57,180,549 bp
  • A to T, chromosome 19 at 23,984,829 bp
  • A to G, chromosome 19 at 37,924,620 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6041 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044209-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.