Strain Name:
C57BL/6J-MtgxR6186Btlr
Stock Number:
044326-MU
Citation ID:
RRID:MMRRC_044326-MU
Other Names:
R6186 (G1)
Major Collection:

Gene Information

Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Ptdss2
Name: phosphatidylserine synthase 2
Synonyms: PSS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27388
Homologene: 8462
Nphs1
Name: nephrosis 1, nephrin
Synonyms: nephrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54631
HGNC: HGNC:7908
Homologene: 20974
Pcm1
Name: pericentriolar material 1
Synonyms: 9430077F19Rik, 2600002H09Rik, C030044G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Mapkap1
Name: mitogen-activated protein kinase associated protein 1
Synonyms: D230039K05Rik, Sin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227743
Homologene: 11473
Mark2
Name: MAP/microtubule affinity regulating kinase 2
Synonyms: Par-1, Emk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13728
HGNC: HGNC:3332
Homologene: 69013
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218503
VEGA: 13
Homologene: 9030
Sumo1
Name: small ubiquitin-like modifier 1
Synonyms: Smt3C, SENTRIN, PIC1, Ubl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22218
Homologene: 2514
Akap8l
Name: A kinase (PRKA) anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54194
VEGA: 17
Homologene: 8658
Rnf123
Name: ring finger protein 123
Synonyms: KPC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 84585
Homologene: 11112
Prkab2
Name: protein kinase, AMP-activated, beta 2 non-catalytic subunit
Synonyms: 5730553K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 108097
HGNC: HGNC:9379
Homologene: 38046
Ldlr
Name: low density lipoprotein receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16835
VEGA: 9
HGNC: HGNC:6547
Homologene: 55469
Mrtfa
Name: myocardin related transcription factor A
Synonyms: Mal, Bsac, MRTF-A, Mkl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223701
Homologene: 32487
Adgrg5
Name: adhesion G protein-coupled receptor G5
Synonyms: LOC382045, PGR27, Gpr114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382045
Homologene: 17828
Rbl2
Name: RB transcriptional corepressor like 2
Synonyms: Rb2, p130, retinoblastoma-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 19651
HGNC: HGNC:9894
Homologene: 4098
Wdr36
Name: WD repeat domain 36
Synonyms: 5730444A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225348
VEGA: 18
Homologene: 6536
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239102
Homologene: 52657
Pdcd1
Name: programmed cell death 1
Synonyms: PD-1, Pdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18566
HGNC: HGNC:8760
Homologene: 3681
Cep164
Name: centrosomal protein 164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214552
Homologene: 51110
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, crash, Adgrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Ushbp1
Name: USH1 protein network component harmonin binding protein 1
Synonyms: MCC2, 2210404N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234395
Homologene: 12914
Zfp458
Name: zinc finger protein 458
Synonyms: Rslcan-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238690
VEGA: 13
Homologene: 128170
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
AW549877
Name: expressed sequence AW549877
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 106064
VEGA: 15
Homologene: 27085
Rhobtb2
Name: Rho-related BTB domain containing 2
Synonyms: Dbc2, E130206H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 246710
VEGA: 14
Homologene: 22873
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546071
Homologene: 66191
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 3830402K23Rik, 4930518F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320558
Homologene: 8604
Myo1h
Name: myosin 1H
Synonyms: 4631401O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231646
Homologene: 82639
Ankrd36
Name: ankyrin repeat domain 36
Synonyms: 1700012M14Rik, GC3, 1700008J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76389
Homologene: 137366
Cog2
Name: component of oligomeric golgi complex 2
Synonyms: 1190002B08Rik, 2700012E02Rik, Cog2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76332
HGNC: HGNC:6546
Homologene: 7206
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215772
Homologene: 100289
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Trp63
Name: transformation related protein 63
Synonyms: KET protein, p63, p73L, Trp53rp1, TAp63, p51/p63, deltaNp63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22061
Homologene: 31189
Zfp276
Name: zinc finger protein (C2H2 type) 276
Synonyms: D8Ertd370e, D8Ertd377e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57247
Homologene: 10731
Apbb1
Name: amyloid beta (A4) precursor protein-binding, family B, member 1
Synonyms: Fe65, Rir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11785
HGNC: HGNC:581
Homologene: 898
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243961
Homologene: 22949
Cyp2j6
Name: cytochrome P450, family 2, subfamily j, polypeptide 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13110
HGNC: HGNC:2634
Homologene: 68091
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 319734
Homologene: 26544
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72277
Fkbpl
Name: FK506 binding protein-like
Synonyms: Ppiase-X, NG7, DIR1, WISp39, WAF-1/CIP1 stabilizing protein 39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56299
Homologene: 10529
Olfr267
Name: olfactory receptor 267
Synonyms: GA_x6K02T2N78B-1272842-1273783, MOR262-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258922
HGNC: HGNC:8264
Homologene: 17436
Ndufa8
Name: NADH:ubiquinone oxidoreductase subunit A8
Synonyms: 0610033L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68375
HGNC: HGNC:7692
Homologene: 40932
Cfap221
Name: cilia and flagella associated protein 221
Synonyms: Pcdp1, Gm101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226356
Homologene: 88578
Fjx1
Name: four jointed box 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14221
Homologene: 7717
Fam205c
Name: family with sequence similarity 205, member C
Synonyms: BC049635
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277773
Homologene: 77625
Zfp526
Name: zinc finger protein 526
Synonyms: D030024H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210172
Homologene: 18447
Timm44
Name: translocase of inner mitochondrial membrane 44
Synonyms: Tim44, Mimt44, D8Ertd118e, 0710005E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21856
Homologene: 4631
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 57257
Homologene: 38143
Rap1b
Name: RAS related protein 1b
Synonyms: 2810443E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215449
VEGA: 10
HGNC: HGNC:9857
Homologene: 68719
Olfr726
Name: olfactory receptor 726
Synonyms: GA_x6K02T2PMLR-5775299-5774334, MOR246-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258313
Homologene: 44957
Cyp2a5
Name: cytochrome P450, family 2, subfamily a, polypeptide 5
Synonyms: Coh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13087
Homologene: 85917
Tbx2
Name: T-box 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21385
Homologene: 38123
Evx1
Name: even-skipped homeobox 1
Synonyms: Evx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14028
HGNC: HGNC:3506
Homologene: 1507
Fam53b
Name: family with sequence similarity 53, member B
Synonyms: A930008G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77938
Homologene: 8776
AA792892
Name: expressed sequence AA792892
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100554
Homologene: 133359
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 59,644,570 bp
  • A to G, chromosome 1 at 71,637,290 bp
  • T to A, chromosome 1 at 94,040,121 bp
  • T to A, chromosome 1 at 119,934,610 bp
  • A to G, chromosome 2 at 34,563,114 bp
  • A to G, chromosome 2 at 36,039,740 bp
  • T to C, chromosome 2 at 102,450,807 bp
  • C to T, chromosome 2 at 178,383,560 bp
  • A to G, chromosome 3 at 97,663,991 bp
  • A to G, chromosome 3 at 109,516,067 bp
  • T to C, chromosome 4 at 42,872,000 bp
  • T to C, chromosome 4 at 58,784,948 bp
  • G to C, chromosome 4 at 96,536,086 bp
  • A to G, chromosome 4 at 123,484,175 bp
  • T to A, chromosome 5 at 94,383,976 bp
  • C to T, chromosome 5 at 114,319,803 bp
  • T to C, chromosome 6 at 52,314,218 bp
  • G to A, chromosome 6 at 119,281,689 bp
  • A to G, chromosome 7 at 25,226,136 bp
  • T to C, chromosome 7 at 26,843,388 bp
  • A to G, chromosome 7 at 30,465,634 bp
  • T to A, chromosome 7 at 44,352,566 bp
  • T to C, chromosome 7 at 105,567,726 bp
  • T to A, chromosome 7 at 132,715,716 bp
  • T to C, chromosome 7 at 141,154,949 bp
  • T to C, chromosome 8 at 4,266,824 bp
  • T to C, chromosome 8 at 41,293,793 bp
  • T to C, chromosome 8 at 70,785,483 bp
  • T to A, chromosome 8 at 71,391,003 bp
  • T to A, chromosome 8 at 82,046,234 bp
  • C to T, chromosome 8 at 91,106,730 bp
  • T to C, chromosome 8 at 94,934,024 bp
  • T to A, chromosome 8 at 123,255,933 bp
  • C to A, chromosome 8 at 124,546,686 bp
  • C to T, chromosome 9 at 21,723,759 bp
  • A to T, chromosome 9 at 45,794,109 bp
  • A to C, chromosome 9 at 108,069,958 bp
  • A to T, chromosome 9 at 122,748,826 bp
  • A to G, chromosome 10 at 10,422,758 bp
  • G to T, chromosome 10 at 117,820,552 bp
  • T to G, chromosome 11 at 5,643,812 bp
  • G to T, chromosome 11 at 85,837,846 bp
  • T to C, chromosome 13 at 67,257,637 bp
  • T to A, chromosome 13 at 98,815,083 bp
  • G to T, chromosome 14 at 31,370,918 bp
  • T to A, chromosome 14 at 50,084,525 bp
  • A to T, chromosome 14 at 55,063,160 bp
  • A to G, chromosome 14 at 69,798,244 bp
  • C to A, chromosome 15 at 3,986,369 bp
  • T to C, chromosome 15 at 81,016,652 bp
  • T to C, chromosome 15 at 85,921,193 bp
  • T to C, chromosome 15 at 99,947,325 bp
  • T to C, chromosome 16 at 25,876,733 bp
  • C to T, chromosome 17 at 32,333,044 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • T to C, chromosome 17 at 34,646,179 bp
  • G to C, chromosome 18 at 32,852,901 bp
  • A to G, chromosome 19 at 7,283,202 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6186 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044326-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.