Strain Name:
C57BL/6J-MtgxR4172Btlr
Stock Number:
044391-MU
Citation ID:
RRID:MMRRC_044391-MU
Other Names:
R4172 (G1)
Major Collection:

Gene Information

Lcat
Name: lecithin cholesterol acyltransferase
Synonyms: D8Wsu61e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16816
HGNC: HGNC:6522
Homologene: 68042
Ube2j2
Name: ubiquitin-conjugating enzyme E2J 2
Synonyms: Ubc6, 1200007B18Rik, 5730472G04Rik, 2400008G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 140499
Homologene: 10975
Rad51c
Name: RAD51 paralog C
Synonyms: Rad51l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 114714
HGNC: HGNC:9820
Homologene: 14238
Shroom3
Name: shroom family member 3
Synonyms: Shrm, Shrm3, D5Ertd287e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Cdc5l
Name: cell division cycle 5-like (S. pombe)
Synonyms: PCDC5RP, 1200002I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71702
VEGA: 17
HGNC: HGNC:1743
Homologene: 13291
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22222
Homologene: 7582
Nop14
Name: NOP14 nucleolar protein
Synonyms: Nol14, 2610033H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75416
Homologene: 41773
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 20658
Homologene: 10551
Mtmr2
Name: myotubularin related protein 2
Synonyms: 6030445P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77116
HGNC: HGNC:7450
Homologene: 22951
Jak1
Name: Janus kinase 1
Synonyms: C130039L05Rik, BAP004
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16451
HGNC: HGNC:6190
Homologene: 1678
Helq
Name: helicase, POLQ-like
Synonyms: Hel308, D430018E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 191578
Homologene: 14667
Kank4
Name: KN motif and ankyrin repeat domains 4
Synonyms: Ankrd38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242553
Homologene: 18244
Il6st
Name: interleukin 6 signal transducer
Synonyms: gp130, CD130, D13Ertd699e, 5133400A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16195
HGNC: HGNC:6021
Homologene: 1645
Map2
Name: microtubule-associated protein 2
Synonyms: G1-397-34, MAP-2, repro4, Mtap2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Tpm1
Name: tropomyosin 1, alpha
Synonyms: TM2, Tm3, alpha-TM, Tpm-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22003
Homologene: 128637
Spint2
Name: serine protease inhibitor, Kunitz type 2
Synonyms: HAI-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20733
Homologene: 7955
Gle1
Name: GLE1 RNA export mediator (yeast)
Synonyms: 4933405K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74412
HGNC: HGNC:4315
Homologene: 20379
Zfp445
Name: zinc finger protein 445
Synonyms: ZNF168
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235682
VEGA: 9
Homologene: 27832
Snx27
Name: sorting nexin family member 27
Synonyms: 5730552M22Rik, ESTM47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76742
Homologene: 12797
Gfra2
Name: glial cell line derived neurotrophic factor family receptor alpha 2
Synonyms: GFR alpha-2, GFR alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14586
VEGA: 14
HGNC: HGNC:4244
Homologene: 1145
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: 4832426G23Rik, Myhs-p, MyHC-pn, Myhsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Akip1
Name: A kinase (PRKA) interacting protein 1
Synonyms: D930014E17Rik, D7H11orf17, ICRFP703N2430Q5.6, BCA3, ORF27, ICRFP703B1614Q5.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57373
HGNC: HGNC:1170
Homologene: 10765
Synm
Name: synemin, intermediate filament protein
Synonyms: Synemin, Dmn, 4930412K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233335
Homologene: 9081
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: Arhgap13, 4930572H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 117600
Homologene: 56898
Guf1
Name: GUF1 homolog, GTPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231279
Homologene: 6505
Paox
Name: polyamine oxidase (exo-N4-amino)
Synonyms: 2410012F02Rik, Pao
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212503
Homologene: 72096
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Vwa5a
Name: von Willebrand factor A domain containing 5A
Synonyms: Loh11cr2a, BCSC-1, 5830475I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67776
HGNC: HGNC:6658
Homologene: 18222
Npbwr1
Name: neuropeptides B/W receptor 1
Synonyms: Gpr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226304
HGNC: HGNC:4522
Homologene: 21096
Olfr48
Name: olfactory receptor 48
Synonyms: IC3, MOR232-5, GA_x6K02T2Q125-51285881-51284976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18347
Homologene: 85936
Oxsm
Name: 3-oxoacyl-ACP synthase, mitochondrial
Synonyms: 4933425A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71147
Homologene: 5820
Trpv6
Name: transient receptor potential cation channel, subfamily V, member 6
Synonyms: CaT1, Cac, Ecac2, CAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 64177
Homologene: 56812
Tex11
Name: testis expressed gene 11
Synonyms: 4930565P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 83558
Homologene: 49962
Ighv7-4
Name: immunoglobulin heavy variable 7-4
Synonyms: Gm16839
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 632654
Spata25
Name: spermatogenesis associated 25
Synonyms: TSG23, 1700020C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75642
Homologene: 15415
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 5,916,936 bp
  • G to T, chromosome 1 at 46,226,946 bp
  • T to C, chromosome 1 at 66,413,600 bp
  • T to C, chromosome 2 at 29,938,526 bp
  • T to G, chromosome 2 at 89,844,778 bp
  • C to A, chromosome 2 at 112,794,470 bp
  • C to T, chromosome 2 at 120,946,622 bp
  • C to A, chromosome 2 at 164,827,488 bp
  • T to C, chromosome 3 at 94,503,487 bp
  • G to T, chromosome 4 at 98,779,121 bp
  • C to A, chromosome 4 at 101,159,132 bp
  • A to G, chromosome 4 at 155,949,086 bp
  • T to C, chromosome 5 at 34,650,607 bp
  • T to A, chromosome 5 at 69,558,229 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • T to C, chromosome 5 at 100,771,847 bp
  • T to C, chromosome 6 at 41,625,498 bp
  • A to G, chromosome 7 at 29,263,672 bp
  • T to C, chromosome 7 at 67,735,361 bp
  • C to T, chromosome 7 at 109,707,509 bp
  • G to A, chromosome 7 at 140,134,028 bp
  • C to A, chromosome 8 at 105,942,427 bp
  • T to C, chromosome 9 at 13,800,062 bp
  • T to C, chromosome 9 at 38,723,870 bp
  • T to C, chromosome 9 at 67,023,367 bp
  • T to A, chromosome 9 at 122,851,937 bp
  • T to C, chromosome 10 at 121,855,363 bp
  • A to T, chromosome 11 at 67,292,421 bp
  • T to C, chromosome 11 at 87,402,746 bp
  • A to T, chromosome 12 at 114,223,015 bp
  • G to A, chromosome 13 at 112,495,327 bp
  • A to T, chromosome 14 at 16,242,079 bp
  • C to A, chromosome 14 at 70,896,081 bp
  • C to T, chromosome 16 at 37,060,758 bp
  • C to T, chromosome 16 at 91,659,362 bp
  • A to G, chromosome 17 at 45,419,772 bp
  • C to A, chromosome X at 100,933,415 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4172 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044391-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.