Strain Name:
C57BL/6J-MtgxR6429Btlr/Mmmh
Stock Number:
044567-MU
Citation ID:
RRID:MMRRC_044567-MU
Other Names:
R6429 (G1)
Major Collection:

Strain Information

Zmpste24
Name: zinc metallopeptidase, STE24
Synonyms: A530043O15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230709
Homologene: 4277
Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22427
Homologene: 6659
Il4
Name: interleukin 4
Synonyms: Il-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16189
HGNC: HGNC:6014
Homologene: 491
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Rngtt
Name: RNA guanylyltransferase and 5'-phosphatase
Synonyms: mouse capping enzyme
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 24018
Homologene: 37851
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: Wwp4, 1110067P07Rik, A230035H12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225131
Homologene: 41148
Zeb1
Name: zinc finger E-box binding homeobox 1
Synonyms: Nil2, [delta]EF1, MEB1, Tcf8, Zfx1a, Tcf18, AREB6, ZEB, Zfhep, 3110032K11Rik, Zfhx1a, Tw
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21417
Homologene: 31779
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Msr1
Name: macrophage scavenger receptor 1
Synonyms: SR-AII, SR-AI, MSR-A, Scara1, Scvr, MRS-A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20288
HGNC: HGNC:7376
Homologene: 12822
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20658
Homologene: 10551
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik, sao
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68750
Homologene: 2218
Grhl3
Name: grainyhead like transcription factor 3
Synonyms: Som, Get1, ct
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230824
Homologene: 18864
Prkag1
Name: protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Synonyms: Prkaac
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19082
VEGA: 15
HGNC: HGNC:9385
Homologene: 99712
Cul2
Name: cullin 2
Synonyms: 1300003D18Rik, 4932411N15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71745
HGNC: HGNC:2552
Homologene: 2662
Supt3
Name: SPT3, SAGA and STAGA complex component
Synonyms: SPT3L, SPT3, 2310066G22Rik, Supt3h
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 109115
Homologene: 121570
Fnip1
Name: folliculin interacting protein 1
Synonyms: A730024A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216742
Homologene: 28173
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Nptx1
Name: neuronal pentraxin 1
Synonyms: Np1, D11Bwg1004e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18164
HGNC: HGNC:7952
Homologene: 1891
Nr1d1
Name: nuclear receptor subfamily 1, group D, member 1
Synonyms: REV-ERBalpha, rev-erbA(alpha), A530070C09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217166
HGNC: HGNC:7962
Homologene: 23324
Amy1
Name: amylase 1, salivary
Synonyms: Amy-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11722
Homologene: 20179
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Vwa7
Name: von Willebrand factor A domain containing 7
Synonyms: G7c, D17H6S56E-3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27762
Homologene: 11895
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: basilin, FOAP-10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 246707
VEGA: 17
Homologene: 36483
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: Mlsn1, 4732499L03Rik, melastatin, LTRPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20274
Homologene: 2237
Arhgef15
Name: Rho guanine nucleotide exchange factor 15
Synonyms: D530030K12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 442801
Homologene: 18345
Krt4
Name: keratin 4
Synonyms: Krt-2.4, K4, Krt2-4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16682
VEGA: 15
HGNC: HGNC:6441
Homologene: 20523
Sfmbt1
Name: Scm-like with four mbt domains 1
Synonyms: Smr, 4930442N21Rik, 9330180L21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54650
Homologene: 9472
Vmn2r70
Name: vomeronasal 2, receptor 70
Synonyms: EG620835
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 670940
Homologene: 115466
Tbx3
Name: T-box 3
Synonyms: D5Ertd189e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21386
Homologene: 4371
Dpp10
Name: dipeptidylpeptidase 10
Synonyms: DPRP3, 6430601K09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269109
Homologene: 41400
Dstyk
Name: dual serine/threonine and tyrosine protein kinase
Synonyms: A930019K20Rik, C430014H23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213452
Homologene: 19711
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244810
HGNC: HGNC:6658
Dgkq
Name: diacylglycerol kinase, theta
Synonyms: Dagk4, 110kDa, DAGK7, Dgkd, Dgk theta
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 110524
HGNC: HGNC:2856
Homologene: 20352
Styk1
Name: serine/threonine/tyrosine kinase 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243659
Homologene: 49545
Ift56
Name: intraflagellar transport 56
Synonyms: hpy, hydrocephalic-polydactyl, 9430097H08Rik, hop, Ttc26
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 264134
Homologene: 11786
Pira13
Name: paired-Ig-like receptor A13
Synonyms: ENSMUSG00000074419, Gm15448
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041146
Homologene: 134028
Ptger4
Name: prostaglandin E receptor 4 (subtype EP4)
Synonyms: Ptgerep4, EP4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19219
HGNC: HGNC:9596
Homologene: 20261
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Il33
Name: interleukin 33
Synonyms: NF-HEV, 9230117N10Rik, Il1f11, Il-33
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 77125
Homologene: 14126
Tspan32
Name: tetraspanin 32
Synonyms: D7Wsu37e, Tssc6, Art-1, Tspan32, Phemx
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27027
Homologene: 10650
Or4c11c
Name: olfactory receptor family 4 subfamily C member 11C
Synonyms: GA_x6K02T2Q125-50336588-50337313, GA_x6K02T2Q125-50304328-50305251, MOR230-1, MOR230-3, Olfr1203, Olfr1205
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258898
Homologene: 81567
Smpd1
Name: sphingomyelin phosphodiesterase 1, acid lysosomal
Synonyms: A-SMase, aSMase, ASM, acid sphingomyelinase, Zn-SMase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20597
Homologene: 457
Rhod
Name: ras homolog family member D
Synonyms: Arhd
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11854
HGNC: HGNC:670
Homologene: 22409
Ccdc87
Name: coiled-coil domain containing 87
Synonyms: 4931419P11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 399599
VEGA: 19
Homologene: 49531
Zfp747l1
Name: zinc finger protein 747 like 1
Synonyms: 9130019O22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78921
Homologene: 118005
Panx3
Name: pannexin 3
Synonyms: 4833413G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208098
Homologene: 82335
Six4
Name: sine oculis-related homeobox 4
Synonyms: AREC3, TrexBF
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20474
Homologene: 69089
Pvrig
Name: poliovirus receptor related immunoglobulin domain containing
Synonyms: Gm36869
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 102640920
Homologene: 78229
Gm35315
Name: predicted gene, 35315
Synonyms: Gm20090
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 102638847
Homologene: 141161
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 123,367,601 bp
  • C to T, chromosome 1 at 132,449,804 bp
  • A to C, chromosome 2 at 66,526,963 bp
  • C to T, chromosome 2 at 69,461,287 bp
  • G to A, chromosome 2 at 88,831,525 bp
  • T to C, chromosome 3 at 113,569,509 bp
  • C to A, chromosome 4 at 33,320,606 bp
  • A to G, chromosome 4 at 121,095,670 bp
  • A to T, chromosome 4 at 123,401,594 bp
  • T to A, chromosome 4 at 135,557,196 bp
  • C to T, chromosome 5 at 73,090,751 bp
  • C to T, chromosome 5 at 108,653,708 bp
  • A to T, chromosome 5 at 110,078,659 bp
  • G to A, chromosome 5 at 114,228,591 bp
  • T to A, chromosome 5 at 119,674,191 bp
  • A to G, chromosome 5 at 138,342,050 bp
  • T to A, chromosome 6 at 38,398,313 bp
  • T to A, chromosome 6 at 131,310,064 bp
  • A to T, chromosome 7 at 3,822,346 bp
  • A to T, chromosome 7 at 64,268,504 bp
  • T to A, chromosome 7 at 85,559,068 bp
  • A to G, chromosome 7 at 100,432,091 bp
  • T to C, chromosome 7 at 105,556,928 bp
  • T to C, chromosome 7 at 127,385,042 bp
  • T to A, chromosome 7 at 143,018,742 bp
  • G to A, chromosome 8 at 33,342,996 bp
  • G to A, chromosome 8 at 39,615,817 bp
  • T to C, chromosome 9 at 37,661,165 bp
  • A to G, chromosome 9 at 39,600,614 bp
  • A to G, chromosome 11 at 53,613,909 bp
  • A to G, chromosome 11 at 54,515,567 bp
  • G to T, chromosome 11 at 68,947,796 bp
  • T to C, chromosome 11 at 98,772,014 bp
  • G to T, chromosome 11 at 119,544,721 bp
  • A to T, chromosome 12 at 73,103,473 bp
  • C to T, chromosome 12 at 112,604,256 bp
  • T to G, chromosome 13 at 37,932,129 bp
  • T to A, chromosome 14 at 30,773,911 bp
  • T to C, chromosome 15 at 5,242,997 bp
  • A to G, chromosome 15 at 98,814,523 bp
  • A to G, chromosome 15 at 101,922,794 bp
  • T to A, chromosome 16 at 34,332,164 bp
  • A to T, chromosome 16 at 90,762,430 bp
  • T to A, chromosome 16 at 91,658,166 bp
  • A to G, chromosome 17 at 35,024,199 bp
  • A to G, chromosome 17 at 45,119,143 bp
  • C to A, chromosome 17 at 71,310,956 bp
  • T to C, chromosome 18 at 3,421,345 bp
  • T to A, chromosome 18 at 5,770,498 bp
  • T to A, chromosome 18 at 7,920,163 bp
  • C to T, chromosome 19 at 4,426,105 bp
  • T to A, chromosome 19 at 4,841,235 bp
  • T to C, chromosome 19 at 21,801,908 bp
  • T to C, chromosome 19 at 29,952,000 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6429 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044567-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.