Strain Name:
C57BL/6J-MtgxR6434Btlr/Mmmh
Stock Number:
044572-MU
Citation ID:
RRID:MMRRC_044572-MU
Other Names:
R6434 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Septin3
Name: septin 3
Synonyms: Sept3, Sep3, Gm46500, 3110018K01Rik, B530002E20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 24050
VEGA: 15
Homologene: 99740
Mga
Name: MAX gene associated
Synonyms: Mga, D030062C11Rik, C130042M01Rik, Mad5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Dnajc11
Name: DnaJ heat shock protein family (Hsp40) member C11
Synonyms: E030019A03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230935
Homologene: 14558
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: 2410030O07Rik, B930014J03Rik, Bmn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Inadl, Cipp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12695
Homologene: 72199
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: Ascc3l1, A330064G03Rik, HELIC2, U5-200KD
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320632
Homologene: 5859
Gtse1
Name: G two S phase expressed protein 1
Synonyms: Gtse-1, B99
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29870
VEGA: 15
Homologene: 8489
Ilf3
Name: interleukin enhancer binding factor 3
Synonyms: NF90
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16201
VEGA: 9
HGNC: HGNC:6038
Homologene: 7785
Wdr48
Name: WD repeat domain 48
Synonyms: Uaf1, 8430408H12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67561
VEGA: 9
Homologene: 10830
Ect2
Name: ect2 oncogene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13605
HGNC: HGNC:3155
Homologene: 7298
Vps35
Name: VPS35 retromer complex component
Synonyms: Mem3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 65114
Homologene: 6221
Ankle2
Name: ankyrin repeat and LEM domain containing 2
Synonyms: 1110001J12Rik, D5Ertd585e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71782
Homologene: 35424
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Atp6v1c1
Name: ATPase, H+ transporting, lysosomal V1 subunit C1
Synonyms: 1700025B18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66335
VEGA: 15
HGNC: HGNC:856
Homologene: 1281
Pex1
Name: peroxisomal biogenesis factor 1
Synonyms: 5430414H02Rik, ZWS1, E330005K07Rik, peroxisome biogenesis factor 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71382
HGNC: HGNC:8850
Homologene: 27006
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Zfp719
Name: zinc finger protein 719
Synonyms: 9430094P17Rik, mszf6, C630016O21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210105
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: heb, eyem02Jus, eyes2, QBRICK, crf11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Nars1
Name: asparaginyl-tRNA synthetase 1
Synonyms: ASNRS, Nars
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70223
VEGA: 18
HGNC: HGNC:7643
Homologene: 68404
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Egfr
Name: epidermal growth factor receptor
Synonyms: 9030024J15Rik, Erbb, Errb1, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Wa5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Muc20
Name: mucin 20
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224116
Homologene: 17135
Npat
Name: nuclear protein in the AT region
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244879
HGNC: HGNC:7896
Homologene: 1888
Inpp4a
Name: inositol polyphosphate-4-phosphatase, type I
Synonyms: 107kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269180
HGNC: HGNC:6074
Homologene: 2871
Mtmr4
Name: myotubularin related protein 4
Synonyms: FYVE zinc finger phosphatase, ESTM44, ZFYVE11, FYVE-DSP2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170749
HGNC: HGNC:7452
Homologene: 3440
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: C730036B14Rik, D12Ertd364e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Atl1
Name: atlastin GTPase 1
Synonyms: FSP1, AD-FSP, Spg3a, SPG3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73991
VEGA: 12
Homologene: 9302
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Kcnh4
Name: potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: BEC2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380728
HGNC: HGNC:6253
Homologene: 8180
Obp2b
Name: odorant binding protein 2B
Synonyms: OTTMUSG00000012631, Lcn14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 383678
Homologene: 135821
Tril
Name: TLR4 interactor with leucine-rich repeats
Synonyms: 1200009O22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66873
Homologene: 69404
Auh
Name: AU RNA binding protein/enoyl-coenzyme A hydratase
Synonyms: W91705
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11992
HGNC: HGNC:890
Homologene: 1284
Myh3
Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic
Synonyms: Myhse, MyHC-emb, Myhs-e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17883
HGNC: HGNC:7573
Homologene: 20553
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Ccdc81
Name: coiled-coil domain containing 81
Synonyms: 4921513D09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70884
Homologene: 128447
Nrxn3
Name: neurexin III
Synonyms: neurexin III beta, neurexin III alpha, D12Bwg0831e, neurexin III alpha, 9330112C09Rik, neurexin III beta, 4933401A11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Slco1c1
Name: solute carrier organic anion transporter family, member 1c1
Synonyms: Slc21a14, OATP-F
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58807
Homologene: 23008
Or7e170
Name: olfactory receptor family 7 subfamily E member 170
Synonyms: GA_x6K02T2PVTD-13624132-13623212, Olfr862, MOR146-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258555
Homologene: 115540
Arhgef26
Name: Rho guanine nucleotide exchange factor 26
Synonyms: 8430436L14Rik, 4631416L12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 622434
Homologene: 9204
Simc1
Name: SUMO-interacting motifs containing 1
Synonyms: 4732471D19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319719
Homologene: 131217
Ccdc96
Name: coiled-coil domain containing 96
Synonyms: 4921513E08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66717
Homologene: 32639
Ifi44
Name: interferon-induced protein 44
Synonyms: MTAP44, p44, A430056A10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99899
Homologene: 4683
Alcam
Name: activated leukocyte cell adhesion molecule
Synonyms: SC1, DM-GRASP, MuSC, BEN, CD166
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11658
HGNC: HGNC:400
Homologene: 1229
Klhl33
Name: kelch-like 33
Synonyms: EG546611
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 546611
VEGA: 14
Homologene: 52385
Yju2b
Name: YJU2 splicing factor homolog B
Synonyms: 4930527D15Rik, Ccdc130
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67736
Homologene: 12183
Klra9
Name: killer cell lectin-like receptor subfamily A, member 9
Synonyms: LY49I1, Ly49I
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16640
Homologene: 110821
Shc3
Name: src homology 2 domain-containing transforming protein C3
Synonyms: ShcC, N-Shc, Rai
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20418
VEGA: 13
Homologene: 7536
Tubb2b
Name: tubulin, beta 2B class IIB
Synonyms: brdp, 2410129E14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73710
VEGA: 13
Homologene: 49734
Ccdc82
Name: coiled-coil domain containing 82
Synonyms: 2310043N13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66396
VEGA: 9
Homologene: 11678
Or5w1
Name: olfactory receptor family 5 subfamily W member 1
Synonyms: MOR176-1, Olfr1134, GA_x6K02T2Q125-49162076-49161138
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259032
Homologene: 37013
Aspdh
Name: aspartate dehydrogenase domain containing
Synonyms: 0610012D14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68352
Homologene: 41692
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Gm3415
Name: predicted gene 3415
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041578
Homologene: 86127
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,398,838 bp
  • T to C, chromosome 2 at 25,738,587 bp
  • T to A, chromosome 2 at 87,656,214 bp
  • A to T, chromosome 2 at 119,923,938 bp
  • T to A, chromosome 2 at 127,238,654 bp
  • A to T, chromosome 3 at 27,139,119 bp
  • A to C, chromosome 3 at 62,428,914 bp
  • T to A, chromosome 3 at 83,269,270 bp
  • T to C, chromosome 3 at 104,491,547 bp
  • G to A, chromosome 3 at 135,511,973 bp
  • T to A, chromosome 3 at 151,749,189 bp
  • A to G, chromosome 4 at 82,966,016 bp
  • A to G, chromosome 4 at 98,491,629 bp
  • T to C, chromosome 4 at 139,429,638 bp
  • T to C, chromosome 4 at 151,979,294 bp
  • T to A, chromosome 5 at 3,630,196 bp
  • T to G, chromosome 5 at 36,486,363 bp
  • A to G, chromosome 5 at 110,253,893 bp
  • T to A, chromosome 5 at 146,557,942 bp
  • G to C, chromosome 6 at 53,818,508 bp
  • G to T, chromosome 6 at 130,179,032 bp
  • T to C, chromosome 6 at 141,547,850 bp
  • C to A, chromosome 7 at 43,590,988 bp
  • G to A, chromosome 7 at 44,467,050 bp
  • T to A, chromosome 7 at 64,354,381 bp
  • T to C, chromosome 7 at 89,876,144 bp
  • A to G, chromosome 8 at 84,263,001 bp
  • C to T, chromosome 8 at 85,273,495 bp
  • T to C, chromosome 9 at 13,252,034 bp
  • A to T, chromosome 9 at 19,883,845 bp
  • A to G, chromosome 9 at 21,403,151 bp
  • A to T, chromosome 9 at 53,563,439 bp
  • T to A, chromosome 9 at 66,486,182 bp
  • C to A, chromosome 9 at 105,937,345 bp
  • T to C, chromosome 9 at 119,916,813 bp
  • A to G, chromosome 10 at 5,318,422 bp
  • A to T, chromosome 10 at 12,525,427 bp
  • A to T, chromosome 10 at 88,772,533 bp
  • T to C, chromosome 11 at 16,869,294 bp
  • T to A, chromosome 11 at 67,082,367 bp
  • A to G, chromosome 11 at 87,613,483 bp
  • T to A, chromosome 11 at 100,750,279 bp
  • T to C, chromosome 12 at 65,077,168 bp
  • G to T, chromosome 12 at 69,959,425 bp
  • T to C, chromosome 12 at 76,041,456 bp
  • T to C, chromosome 12 at 88,795,515 bp
  • C to T, chromosome 13 at 34,127,578 bp
  • A to G, chromosome 13 at 51,449,290 bp
  • C to A, chromosome 13 at 52,929,410 bp
  • A to G, chromosome 13 at 54,526,664 bp
  • A to T, chromosome 13 at 95,682,933 bp
  • G to A, chromosome 14 at 50,893,107 bp
  • T to C, chromosome 15 at 38,677,546 bp
  • G to A, chromosome 15 at 82,279,603 bp
  • C to A, chromosome 15 at 85,875,169 bp
  • A to G, chromosome 16 at 32,794,806 bp
  • A to C, chromosome 16 at 52,288,827 bp
  • T to C, chromosome 18 at 64,507,801 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6434 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044572-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.