Strain Name:
C57BL/6J-MtgxR6547Btlr/Mmmh
Stock Number:
044672-MU
Citation ID:
RRID:MMRRC_044672-MU
Other Names:
R6547 (G1)
Major Collection:

Strain Information

Limch1
Name: LIM and calponin homology domains 1
Synonyms: 3732412D22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77569
Homologene: 18953
Hcn2
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2
Synonyms: HAC1, trls
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15166
HGNC: HGNC:4846
Homologene: 31022
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: Tmem2, 3110012M15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Nploc4
Name: NPL4 homolog, ubiquitin recognition factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217365
Homologene: 5403
Tefm
Name: transcription elongation factor, mitochondrial
Synonyms: 1110002N22Rik, FLJ22729
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68550
Homologene: 11657
Ric1
Name: RAB6A GEF complex partner 1
Synonyms: C130057E09Rik, C030046E11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226089
Homologene: 13806
Rtn1
Name: reticulon 1
Synonyms: Rtn1-c, 0710005K15Rik, Rtn1-a, Nsp, 4930441F12Rik, Rtn1-b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104001
Homologene: 49654
Calcr
Name: calcitonin receptor
Synonyms: Clr
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12311
HGNC: HGNC:1440
Homologene: 1320
Syt14
Name: synaptotagmin XIV
Synonyms: B230320I09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329324
Homologene: 17719
Bbs9
Name: Bardet-Biedl syndrome 9
Synonyms: E130103I17Rik, EST 3159894
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319845
Homologene: 44480
Anxa7
Name: annexin A7
Synonyms: Anx7, synexin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11750
VEGA: 14
HGNC: HGNC:545
Homologene: 36149
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Pdlim1
Name: PDZ and LIM domain 1 (elfin)
Synonyms: CLP36, mClim1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54132
HGNC: HGNC:2067
Homologene: 9643
Zswim1
Name: zinc finger SWIM-type containing 1
Synonyms: 2410003H12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71971
Homologene: 12429
Zbtb10
Name: zinc finger and BTB domain containing 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229055
Homologene: 11395
Rap1gds1
Name: RAP1, GTP-GDP dissociation stimulator 1
Synonyms: GDS1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229877
HGNC: HGNC:9859
Homologene: 41422
Clec9a
Name: C-type lectin domain family 9, member a
Synonyms: 9830005G06Rik, DNGR-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232414
Homologene: 52106
Colec12
Name: collectin sub-family member 12
Synonyms: SRCL, CL-P1, Scara4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 140792
VEGA: 18
Homologene: 34248
Tcaim
Name: T cell activation inhibitor, mitochondrial
Synonyms: LOC382117, D9Ertd402e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382117
Homologene: 45481
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Synonyms: mineralocorticoid receptor, Mlr, aldosterone receptor, MR
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110784
HGNC: HGNC:7979
Homologene: 121495
Tspan11
Name: tetraspanin 11
Synonyms: 1110014F12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68498
Homologene: 23595
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Slc4a1
Name: solute carrier family 4 (anion exchanger), member 1
Synonyms: l11Jus51, Empb3, CD233, erythrocyte membrane protein band 3, band 3, Ae1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20533
Homologene: 133556
Fa2h
Name: fatty acid 2-hydroxylase
Synonyms: G630055L08Rik, Faxdc1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 338521
Homologene: 56284
Slc26a6
Name: solute carrier family 26, member 6
Synonyms: Pat1, CFEX, B930010B04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 171429
Homologene: 99903
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, Scn2a1, A230052E19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110876
Homologene: 75001
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mouse
Chromosome: 2
Arl9
Name: ADP-ribosylation factor-like 9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384185
Homologene: 66207
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Dcdc3, mG145, oxygen-regulated protein 1, Orp1, Rp1h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Stk33
Name: serine/threonine kinase 33
Synonyms: 4921505G21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 117229
Homologene: 75307
Hycc1
Name: hyccin PI4KA lipid kinase complex subunit 1
Synonyms: hyccin, Fam126a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 84652
Homologene: 57175
Serpina1a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1A
Synonyms: Spi1-1, PI1, Aat2, Aat-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20700
HGNC: HGNC:8941
Homologene: 20103
Mppe1
Name: metallophosphoesterase 1
Synonyms: Pgap5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225651
VEGA: 18
Homologene: 41512
Or8a1
Name: olfactory receptor family 8 subfamily A member 1
Synonyms: GA_x6K02T2PVTD-31408136-31407207, M71, MOR171-2, Olfr151
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 406176
HGNC: HGNC:8469
Homologene: 12726
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Fmi1, flamingo, Adgrc3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, actin binding protein 280, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Ablim3
Name: actin binding LIM protein family, member 3
Synonyms: D930036B08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319713
VEGA: 18
Homologene: 69175
Kbtbd11
Name: kelch repeat and BTB (POZ) domain containing 11
Synonyms: 4930465M17Rik, 2900016B01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74901
Homologene: 28701
Unc5c
Name: unc-5 netrin receptor C
Synonyms: Unc5h3, B130051O18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22253
Homologene: 2765
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12722
HGNC: HGNC:2017
Homologene: 77224
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Dffry, Fafl2
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 107868
Homologene: 68408
Zswim5
Name: zinc finger SWIM-type containing 5
Synonyms: 4933426E21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74464
Homologene: 18958
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75721
Homologene: 138468
Tekt3
Name: tektin 3
Synonyms: 4933407G07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71062
Homologene: 12896
Zfp316
Name: zinc finger protein 316
Synonyms: Emzf1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54201
Homologene: 69231
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: ThTr2, A230084E24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 80721
Homologene: 23530
Slc2a5
Name: solute carrier family 2 (facilitated glucose transporter), member 5
Synonyms: GLUT5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56485
Homologene: 74459
Pate13
Name: prostate and testis expressed 13
Synonyms: 9230113P08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77908
Msc
Name: musculin
Synonyms: bHLHa22, MyoR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17681
HGNC: HGNC:7321
Homologene: 3738
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 4,170,305 bp
  • A to C, chromosome 1 at 14,755,745 bp
  • A to G, chromosome 1 at 83,022,900 bp
  • G to T, chromosome 1 at 192,901,869 bp
  • G to T, chromosome 2 at 25,433,338 bp
  • A to G, chromosome 2 at 65,715,897 bp
  • A to T, chromosome 2 at 68,659,907 bp
  • AAGT to AAGTAGT, chromosome 2 at 98,663,803 bp
  • A to G, chromosome 2 at 164,824,796 bp
  • G to A, chromosome 3 at 9,251,703 bp
  • C to A, chromosome 3 at 138,955,338 bp
  • A to T, chromosome 3 at 141,790,019 bp
  • C to T, chromosome 3 at 144,736,947 bp
  • T to C, chromosome 4 at 116,986,903 bp
  • T to A, chromosome 4 at 150,135,619 bp
  • T to C, chromosome 5 at 23,965,100 bp
  • A to T, chromosome 5 at 67,028,774 bp
  • A to G, chromosome 5 at 77,010,410 bp
  • A to T, chromosome 5 at 143,254,197 bp
  • A to T, chromosome 6 at 3,717,177 bp
  • A to G, chromosome 6 at 29,448,608 bp
  • T to A, chromosome 6 at 127,949,803 bp
  • T to A, chromosome 6 at 129,416,376 bp
  • T to C, chromosome 7 at 109,320,835 bp
  • T to A, chromosome 8 at 15,027,641 bp
  • A to T, chromosome 8 at 76,908,809 bp
  • T to C, chromosome 8 at 111,348,020 bp
  • T to C, chromosome 9 at 22,514,069 bp
  • T to A, chromosome 9 at 35,908,485 bp
  • T to A, chromosome 9 at 37,730,495 bp
  • T to C, chromosome 9 at 53,440,157 bp
  • C to A, chromosome 9 at 67,973,365 bp
  • T to A, chromosome 9 at 108,829,128 bp
  • T to A, chromosome 9 at 108,860,782 bp
  • T to A, chromosome 9 at 122,814,466 bp
  • A to G, chromosome 10 at 39,073,656 bp
  • T to A, chromosome 10 at 77,995,354 bp
  • G to T, chromosome 10 at 79,717,152 bp
  • T to A, chromosome 11 at 9,274,757 bp
  • T to A, chromosome 11 at 63,070,478 bp
  • T to G, chromosome 11 at 80,140,384 bp
  • T to A, chromosome 11 at 102,356,735 bp
  • A to G, chromosome 11 at 120,428,522 bp
  • G to T, chromosome 12 at 72,308,761 bp
  • C to T, chromosome 12 at 103,855,921 bp
  • A to G, chromosome 14 at 20,469,393 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • G to T, chromosome 18 at 9,840,351 bp
  • T to C, chromosome 18 at 61,823,929 bp
  • T to C, chromosome 18 at 67,228,988 bp
  • A to T, chromosome 19 at 21,844,831 bp
  • A to G, chromosome 19 at 29,594,826 bp
  • G to A, chromosome 19 at 40,223,120 bp
  • G to T, chromosome 19 at 56,351,566 bp
  • A to T, chromosome Y at 1,444,612 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6547 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044672-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.