Strain Name:
C57BL/6J-MtgxR6558Btlr/Mmmh
Stock Number:
044682-MU
Citation ID:
RRID:MMRRC_044682-MU
Other Names:
R6558 (G1)
Major Collection:

Strain Information

Stoml1
Name: stomatin-like 1
Synonyms: UNC-24, WPB72, SLP-1, 1810015E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69106
VEGA: 9
Homologene: 31265
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21853
Homologene: 31206
Sec23a
Name: SEC23 homolog A, COPII coat complex component
Synonyms: Msec23, Sec23r
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20334
Homologene: 4642
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 360013
Homologene: 7977
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox1, Xox-1, xanthine oxidase, Xor, XO
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Fam83h
Name: family with sequence similarity 83, member H
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105732
VEGA: 15
Homologene: 15890
Ahi1
Name: Abelson helper integration site 1
Synonyms: 1700015F03Rik, Ahi-1, Jouberin, D10Bwg0629e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Cftr
Name: cystic fibrosis transmembrane conductance regulator
Synonyms: Abcc7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12638
HGNC: HGNC:1884
Homologene: 55465
Myadm
Name: myeloid-associated differentiation marker
Synonyms: D7Wsu62e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50918
HGNC: HGNC:7544
Homologene: 9668
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171395
Homologene: 51376
Htr7
Name: 5-hydroxytryptamine (serotonin) receptor 7
Synonyms: 5-HT7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15566
HGNC: HGNC:5302
Homologene: 20244
Cxcl5
Name: C-X-C motif chemokine ligand 5
Synonyms: LIX, Scyb5, AMCF-II, Cxcl6, ENA-78, granulocyte chemotactic protein-2, GCP-2, Scyb6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20311
Homologene: 88671
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53867
Homologene: 9253
Hoxc11
Name: homeobox C11
Synonyms: Hox-3.7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109663
HGNC: HGNC:5123
Homologene: 130362
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Drc3
Name: dynein regulatory complex subunit 3
Synonyms: m6Bei, 4930449E07Rik, Lrrc48
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74665
Homologene: 12581
Ifi208
Name: interferon activated gene 208
Synonyms: E430029J22Rik, Pyr-rv1, Pydc3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100033459
HGNC: HGNC:5395
Homologene: 115929
Anxa3
Name: annexin A3
Synonyms: Anx3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11745
HGNC: HGNC:541
Homologene: 68445
Or5p80
Name: olfactory receptor family 5 subfamily P member 80
Synonyms: MOR204-6, Olfr508, GA_x6K02T2PBJ9-10959726-10960658
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258769
Homologene: 72039
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: Tmem180, 4930449A08Rik, 4930538D17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75146
Homologene: 12592
Cog2
Name: component of oligomeric golgi complex 2
Synonyms: 2700012E02Rik, 1190002B08Rik, Cog2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76332
HGNC: HGNC:6546
Homologene: 7206
Ogfr
Name: opioid growth factor receptor
Synonyms: 2010013E17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72075
Homologene: 7199
Zkscan6
Name: zinc finger with KRAB and SCAN domains 6
Synonyms: Zfp535, D11Ertd714e, KOX11, 1700128E15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52712
Homologene: 12119
Map7d1
Name: MAP7 domain containing 1
Synonyms: Parcc1, Mtap7d1, Rprc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 245877
Homologene: 17009
Unc5c
Name: unc-5 netrin receptor C
Synonyms: Unc5h3, B130051O18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22253
Homologene: 2765
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: eb, 4931400F03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74053
Homologene: 12938
Chml
Name: choroideremia-like
Synonyms: Rep2, E030003F13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12663
HGNC: HGNC:1941
Homologene: 31055
Lrrc71
Name: leucine rich repeat containing 71
Synonyms: 4933430H15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74485
Homologene: 83646
Cxcl2
Name: C-X-C motif chemokine ligand 2
Synonyms: Scyb, MIP-2, Mip2, GROb, Scyb2, Mgsa-b, Gro2, MIP-2a, CINC-2a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20310
Homologene: 117695
Stra8
Name: stimulated by retinoic acid gene 8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20899
Homologene: 49197
Or2r11
Name: olfactory receptor family 2 subfamily R member 11
Synonyms: Olfr458, GA_x6K02T2P3E9-5100053-5100994, MOR257-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258436
Homologene: 133704
Dpt
Name: dermatopontin
Synonyms: 5033416F05Rik, 1810032B19Rik, early quiescence protein-1, EQ-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56429
HGNC: HGNC:3011
Homologene: 1458
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 164,796,811 bp
  • C to T, chromosome 1 at 173,683,023 bp
  • A to T, chromosome 1 at 175,687,182 bp
  • G to T, chromosome 2 at 177,314,554 bp
  • C to T, chromosome 2 at 180,595,404 bp
  • G to A, chromosome 3 at 87,742,643 bp
  • A to T, chromosome 3 at 141,789,729 bp
  • G to A, chromosome 4 at 126,232,909 bp
  • A to G, chromosome 5 at 90,759,818 bp
  • T to C, chromosome 5 at 90,904,365 bp
  • A to G, chromosome 5 at 96,812,939 bp
  • T to C, chromosome 6 at 18,222,528 bp
  • G to A, chromosome 6 at 34,933,040 bp
  • T to A, chromosome 6 at 42,460,777 bp
  • T to A, chromosome 7 at 3,297,061 bp
  • T to A, chromosome 7 at 108,630,188 bp
  • T to C, chromosome 8 at 124,550,232 bp
  • C to T, chromosome 9 at 20,779,033 bp
  • T to A, chromosome 9 at 58,256,668 bp
  • T to C, chromosome 10 at 20,963,673 bp
  • A to G, chromosome 10 at 119,454,383 bp
  • T to A, chromosome 10 at 128,249,563 bp
  • C to T, chromosome 11 at 8,889,052 bp
  • A to T, chromosome 11 at 60,364,892 bp
  • A to T, chromosome 11 at 65,828,225 bp
  • A to G, chromosome 11 at 77,850,852 bp
  • A to T, chromosome 12 at 59,004,552 bp
  • C to G, chromosome 14 at 123,486,507 bp
  • T to C, chromosome 15 at 76,004,453 bp
  • T to C, chromosome 15 at 102,954,866 bp
  • T to G, chromosome 17 at 73,893,713 bp
  • T to C, chromosome 19 at 36,057,240 bp
  • T to A, chromosome 19 at 46,366,478 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6558 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044682-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.