Strain Name:
C57BL/6J-MtgxR6593Btlr/Mmmh
Stock Number:
044717-MU
Citation ID:
RRID:MMRRC_044717-MU
Other Names:
R6593 (G1)
Major Collection:

Strain Information

Elavl3
Name: ELAV like RNA binding protein 3
Synonyms: Huc, mHuC, 2600009P04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15571
VEGA: 9
HGNC: HGNC:3314
Homologene: 31035
Arhgef10
Name: Rho guanine nucleotide exchange factor 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234094
Homologene: 22827
Gpr88
Name: G-protein coupled receptor 88
Synonyms: Strg
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64378
HGNC: HGNC:4539
Homologene: 11104
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Sec24d
Name: SEC24 homolog D, COPII coat complex component
Synonyms: LOC383951, 2310020L09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69608
Homologene: 40986
Washc2
Name: WASH complex subunit 2
Synonyms: Fam21, D6Wsu116e, C530005J20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28006
Homologene: 41686
Cep290
Name: centrosomal protein 290
Synonyms: Kiaa, b2b1454Clo, b2b1752Clo, Nphp6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Traf3ip1
Name: TRAF3 interacting protein 1
Synonyms: MIP-T3, 3930402D05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74019
Homologene: 22913
Rbbp4
Name: retinoblastoma binding protein 4, chromatin remodeling factor
Synonyms: CAF-1 p48 subunit, RBAP48
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19646
HGNC: HGNC:9887
Homologene: 21153
Atg2b
Name: autophagy related 2B
Synonyms: C030004M05Rik, 2410024A21Rik, C630028L02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Xpo7
Name: exportin 7
Synonyms: 4930506C02Rik, Ranbp16
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65246
VEGA: 14
Homologene: 22857
Stt3b
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
Synonyms: 1300006C19Rik, Simp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68292
VEGA: 9
Homologene: 7387
Clic6
Name: chloride intracellular channel 6
Synonyms: 5730466J16Rik, CLIC1L
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 209195
HGNC: HGNC:2065
Homologene: 43154
Lpar1
Name: lysophosphatidic acid receptor 1
Synonyms: Edg2, Gpcr26, LPA1, Kdt2, vzg-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14745
HGNC: HGNC:3166
Homologene: 1072
Zfp799
Name: zinc finger protein 799
Synonyms: 6030490I01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240064
Homologene: 107106
Neto2
Name: neuropilin (NRP) and tolloid (TLL)-like 2
Synonyms: 5530601C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74513
Homologene: 32387
Stra6
Name: stimulated by retinoic acid gene 6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20897
Homologene: 7554
Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Synonyms: cyclooxygenase-2, PGHS-2, prostaglandin G/H synthase, cyclooxygenase 2, Cox-2, PHS-2, COX2, Pghs2, Tis10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19225
HGNC: HGNC:9605
Homologene: 31000
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242505
Homologene: 28424
Gstm3
Name: glutathione S-transferase, mu 3
Synonyms: mGSTM5, Fsc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14864
HGNC: HGNC:4632
Homologene: 37356
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80797
HGNC: HGNC:2017
Homologene: 77224
Farp2
Name: FERM, RhoGEF and pleckstrin domain protein 2
Synonyms: D030026M03Rik, Fir
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227377
Homologene: 8877
Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Synonyms: mdr, Mdr1b, Mdr1, Pgy-1, Abcb1, Pgy1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18669
HGNC: HGNC:40
Homologene: 69084
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Phldb2
Name: pleckstrin homology like domain, family B, member 2
Synonyms: C820004H04Rik, LL5b, LL5beta
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208177
Homologene: 17100
Gcc2
Name: GRIP and coiled-coil domain containing 2
Synonyms: 2600014C01Rik, 0610043A03Rik, 2210420P05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70297
Homologene: 45639
Slc9b1
Name: solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
Synonyms: Nhedc1, 4933424B12Rik, 4933425K02Rik, 1700094G20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74446
Homologene: 49914
Dnase2b
Name: deoxyribonuclease II beta
Synonyms: Dlad, DnaseIIb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56629
Homologene: 1052
Rigi
Name: RNA sensor RIG-I
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIG-I, Ddx58, 6430573D20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230073
Homologene: 32215
AI597479
Name: expressed sequence AI597479
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98404
Homologene: 11459
Or52n3
Name: olfactory receptor family 52 subfamily N member 3
Synonyms: GA_x6K02T2PBJ9-7509539-7510489, MOR34-7, Olfr665
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258810
Homologene: 110477
Cpsf4l
Name: cleavage and polyadenylation specific factor 4-like
Synonyms: 1500000C01Rik, D11Ertd636e, 0610010C04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52670
Homologene: 32669
Odad1
Name: outer dynein arm docking complex subunit 1
Synonyms: Ccdc114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211535
Homologene: 128610
Krtap5-2
Name: keratin associated protein 5-2
Synonyms: 4833428E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71623
Pcdhgb1
Name: protocadherin gamma subfamily B, 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93699
HGNC: HGNC:8708
Homologene: 81867
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 43,111,248 bp
  • A to G, chromosome 1 at 91,527,695 bp
  • A to C, chromosome 1 at 93,569,940 bp
  • G to A, chromosome 1 at 150,101,033 bp
  • T to A, chromosome 3 at 107,968,195 bp
  • T to C, chromosome 3 at 116,252,624 bp
  • T to C, chromosome 3 at 123,353,412 bp
  • T to C, chromosome 3 at 135,357,458 bp
  • A to G, chromosome 3 at 144,808,577 bp
  • T to C, chromosome 3 at 146,586,911 bp
  • T to C, chromosome 4 at 40,226,651 bp
  • A to T, chromosome 4 at 58,486,605 bp
  • G to T, chromosome 4 at 73,745,090 bp
  • A to G, chromosome 4 at 129,322,375 bp
  • C to T, chromosome 4 at 148,010,769 bp
  • C to A, chromosome 5 at 8,853,491 bp
  • T to A, chromosome 6 at 116,259,249 bp
  • T to A, chromosome 7 at 45,947,384 bp
  • C to T, chromosome 7 at 104,881,433 bp
  • A to T, chromosome 7 at 142,174,960 bp
  • T to C, chromosome 8 at 14,962,522 bp
  • T to C, chromosome 8 at 14,962,564 bp
  • A to G, chromosome 8 at 85,669,546 bp
  • C to T, chromosome 9 at 22,018,547 bp
  • A to G, chromosome 9 at 58,151,979 bp
  • T to C, chromosome 9 at 115,252,511 bp
  • T to A, chromosome 10 at 58,271,507 bp
  • T to C, chromosome 10 at 100,508,776 bp
  • G to T, chromosome 11 at 113,709,366 bp
  • A to G, chromosome 12 at 105,644,848 bp
  • G to A, chromosome 14 at 24,150,652 bp
  • G to A, chromosome 14 at 70,682,362 bp
  • G to A, chromosome 16 at 45,825,427 bp
  • A to G, chromosome 16 at 92,528,117 bp
  • A to G, chromosome 17 at 32,819,790 bp
  • G to T, chromosome 18 at 37,682,081 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6593 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044717-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.