Strain Name:
C57BL/6J-MtgxR6623Btlr/Mmmh
Stock Number:
044745-MU
Citation ID:
RRID:MMRRC_044745-MU
Other Names:
R6623 (G1)
Major Collection:

Strain Information

Ankrd13a
Name: ankyrin repeat domain 13a
Synonyms: 1100001D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68420
Homologene: 23814
Plxna1
Name: plexin A1
Synonyms: NOV, Plxn1, PlexA1, 2600013D04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Supt20
Name: SPT20 SAGA complex component
Synonyms: p38IP, D3Ertd300e, Fam48a, p38 interacting protein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56790
Homologene: 134155
Map3k11
Name: mitogen-activated protein kinase kinase kinase 11
Synonyms: Mlk3, 2610017K16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26403
VEGA: 19
HGNC: HGNC:6850
Homologene: 37618
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: A530025K05Rik, Acac, Acc1, LOC327983, acetyl-CoA carboxylase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Klc1
Name: kinesin light chain 1
Synonyms: Kns2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16593
HGNC: HGNC:6387
Homologene: 4056
Prokr2
Name: prokineticin receptor 2
Synonyms: Gpr73l1, EG-VEGRF2, Gpcr73l1, PKR2, B830005M06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 246313
Homologene: 16368
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: SRC-2, Grip1, TIF2/GRIP-1, D1Ertd433e, KAT13C, glucocorticoid receptor-interacting protein 1, bHLHe75, TIF2, TIF-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Sv2b
Name: synaptic vesicle glycoprotein 2b
Synonyms: A830038F04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64176
Homologene: 32236
Prl
Name: prolactin
Synonyms: Prl, Prl1a1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19109
HGNC: HGNC:9445
Homologene: 732
Stxbp2
Name: syntaxin binding protein 2
Synonyms: Munc-18-2, Munc18b, muSec1, C79054, Sxtp2, Munc-18b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20911
Homologene: 55530
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Atxn7
Name: ataxin 7
Synonyms: A430107N12Rik, ataxin-7, Sca7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 246103
VEGA: 14
Homologene: 30967
Lnx2
Name: ligand of numb-protein X 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140887
Homologene: 17737
Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif 1
Synonyms: METH-1, ADAM-TS1, METH1, ADAMTS-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Vmn1r217
Name: vomeronasal 1 receptor 217
Synonyms: V1rh14
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171273
Homologene: 110880
Or52i2
Name: olfactory receptor family 52 subfamily J member 2
Synonyms: MOR41-1, GA_x6K02T2PBJ9-5386601-5387575, Olfr556
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258749
Homologene: 17380
Pcdhb12
Name: protocadherin beta 12
Synonyms: PcdhbL, Pcdh3, Pcdhb5F
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93883
HGNC: HGNC:8690
Homologene: 87126
Myrf
Name: myelin regulatory factor
Synonyms: LOC225908, Gm98, LOC386531
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225908
HGNC: HGNC:1181
Homologene: 32167
Vmn1r113
Name: vomeronasal 1 receptor 113
Synonyms: Gm5748
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 436135
Homologene: 104166
Abcc10
Name: ATP-binding cassette, sub-family C member 10
Synonyms: Mrp7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66673
VEGA: 19
Homologene: 8986
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042810
Homologene: 113703
Itfg2
Name: integrin alpha FG-GAP repeat containing 2
Synonyms: 2700050P07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101142
Homologene: 10211
Asic5
Name: acid-sensing ion channel family member 5
Synonyms: Accn5, BLINaC, brain-liver-intestine amiloride-sensitive sodium channel
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 58170
Homologene: 41171
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Slc2a12
Name: solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms: GLUT-12, Glut12
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353169
Homologene: 59263
Fndc3c1
Name: fibronectin type III domain containing 3C1
Synonyms: LOC333564
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 333564
Homologene: 46440
Cstdc2
Name: cystatin domain containing 2
Synonyms: 9230104L09Rik, mCST E2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77705
Homologene: 87070
Igkv10-96
Name: immunoglobulin kappa variable 10-96
Synonyms: Gm16637
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 692165
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 13,181,297 bp
  • A to G, chromosome 1 at 150,758,306 bp
  • G to T, chromosome 2 at 132,373,574 bp
  • A to T, chromosome 2 at 148,850,762 bp
  • A to G, chromosome 3 at 54,718,294 bp
  • G to A, chromosome 3 at 82,008,585 bp
  • A to G, chromosome 5 at 114,786,757 bp
  • A to G, chromosome 5 at 147,024,487 bp
  • T to G, chromosome 6 at 68,632,174 bp
  • A to T, chromosome 6 at 89,322,771 bp
  • G to T, chromosome 6 at 128,411,657 bp
  • T to C, chromosome 7 at 8,471,501 bp
  • T to A, chromosome 7 at 20,788,066 bp
  • T to A, chromosome 7 at 75,206,384 bp
  • T to A, chromosome 7 at 85,407,101 bp
  • T to G, chromosome 7 at 102,670,034 bp
  • G to A, chromosome 7 at 141,639,559 bp
  • T to C, chromosome 8 at 3,632,561 bp
  • T to A, chromosome 10 at 22,664,900 bp
  • A to C, chromosome 11 at 84,371,499 bp
  • C to A, chromosome 12 at 111,806,041 bp
  • T to C, chromosome 13 at 11,710,065 bp
  • T to A, chromosome 13 at 23,114,676 bp
  • G to T, chromosome 13 at 27,061,509 bp
  • T to C, chromosome 14 at 14,099,972 bp
  • A to G, chromosome 16 at 85,795,637 bp
  • T to C, chromosome 17 at 46,323,462 bp
  • C to T, chromosome 18 at 37,437,658 bp
  • A to G, chromosome 19 at 5,695,603 bp
  • C to A, chromosome 19 at 10,223,359 bp
  • C to T, chromosome 19 at 48,788,505 bp
  • G to C, chromosome X at 106,435,073 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6623 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044745-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.