Strain Name:
C57BL/6J-MtgxR6723Btlr/Mmmh
Stock Number:
044841-MU
Citation ID:
RRID:MMRRC_044841-MU
Other Names:
R6723 (G1)
Major Collection:

Strain Information

Slc12a6
Name: solute carrier family 12, member 6
Synonyms: KCC3, gaxp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107723
Homologene: 21069
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Dhdds
Name: dehydrodolichyl diphosphate synthase
Synonyms: 3222401G21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67422
Homologene: 32615
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, D430004I05Rik, A130082H20Rik, TIF1alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Zfp1
Name: zinc finger protein 1
Synonyms: mkr-1, Zfp-1, Fnp-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22640
Homologene: 32132
Mff
Name: mitochondrial fission factor
Synonyms: 5230400G24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75734
Homologene: 87000
Rag1
Name: recombination activating 1
Synonyms: Rag-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19373
HGNC: HGNC:9831
Homologene: 387
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: 5830462I21Rik, JHDM2B, Jmjd1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67299
Homologene: 23566
Lrig1
Name: leucine-rich repeats and immunoglobulin-like domains 1
Synonyms: LIG-1, Img
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16206
Homologene: 7380
Unc5a
Name: unc-5 netrin receptor A
Synonyms: Unc5h1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107448
Homologene: 41474
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Mrpl15
Name: mitochondrial ribosomal protein L15
Synonyms: MRP-L7, Rpml7, HSPC145
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27395
Homologene: 32210
Inpp5j
Name: inositol polyphosphate 5-phosphatase J
Synonyms: Pipp, Pib5pa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170835
HGNC: HGNC:8956
Homologene: 8682
Nlrp3
Name: NLR family, pyrin domain containing 3
Synonyms: NALP3, Pypaf1, Cias1, Mmig1, cryopyrin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216799
Homologene: 3600
Notch1
Name: notch 1
Synonyms: lin-12, Tan1, Mis6, 9930111A19Rik, Motch A, N1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Tbl2
Name: transducin (beta)-like 2
Synonyms: WS-bTRP, C76179
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27368
Homologene: 8260
Rae1
Name: ribonucleic acid export 1
Synonyms: MNRP41, MNRP, 41, D2Ertd342e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66679
HGNC: HGNC:9828
Homologene: 2676
Fam13c
Name: family with sequence similarity 13, member C
Synonyms: C030038O19Rik, 1200015N20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71721
Homologene: 11490
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216345
Homologene: 17017
Fam13b
Name: family with sequence similarity 13, member B
Synonyms: 2610024E20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225358
VEGA: 18
HGNC: HGNC:1335
Homologene: 9585
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Piezo1, Fam38a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234839
Homologene: 124356
Parm1
Name: prostate androgen-regulated mucin-like protein 1
Synonyms: 2210012L08Rik, 9130213B05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231440
Homologene: 41036
Pkd2l2
Name: polycystic kidney disease 2-like 2
Synonyms: Polycystin - L2, TRPP5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53871
VEGA: 18
HGNC: HGNC:9012
Homologene: 22812
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: Fam75d1c, 4932441B19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238683
VEGA: 13
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ttc16
Name: tetratricopeptide repeat domain 16
Synonyms: 1200002K10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 338348
Homologene: 17011
Gm5134
Name: predicted gene 5134
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 333669
Homologene: 129891
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Fgd5
Name: FYVE, RhoGEF and PH domain containing 5
Synonyms: ZFYVE23, C330025N11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232237
Homologene: 27798
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Or5k1
Name: olfactory receptor family 5 subfamily K member 1
Synonyms: GA_x54KRFPKG5P-54960233-54959268, MOR184-3, Olfr173
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259002
Homologene: 45084
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Or10a49
Name: olfactory receptor family 10 subfamily A member 49
Synonyms: GA_x6K02T2PBJ9-11199311-11198367, MOR268-4, Olfr517
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258136
Homologene: 79413
Ift140
Name: intraflagellar transport 140
Synonyms: Wdtc2, Tce5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106633
Homologene: 40979
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Akt3
Name: thymoma viral proto-oncogene 3
Synonyms: PKB gamma, D930002M15Rik, Nmf350
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23797
HGNC: HGNC:393
Homologene: 55904
Vmn1r63
Name: vomeronasal 1 receptor 63
Synonyms: V1R1, V1rd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81017
Homologene: 41799
Plekhn1
Name: pleckstrin homology domain containing, family N member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231002
VEGA: 4
Homologene: 12949
Or4c116
Name: olfactory receptor family 4 subfamily C member 116
Synonyms: GA_x6K02T2Q125-50591144-50590209, MOR233-3, Olfr1221
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258904
Homologene: 73987
Mylk
Name: myosin, light polypeptide kinase
Synonyms: telokin, Mlck, MLCK210, MLCK108, 9530072E15Rik, A930019C19Rik, nmMlck
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Ugt1a6b
Name: UDP glucuronosyltransferase 1 family, polypeptide A6B
Synonyms: A9'
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394435
Homologene: 85959
Whamm
Name: WAS protein homolog associated with actin, golgi membranes and microtubules
Synonyms: Whdc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434204
Homologene: 45851
Klhl25
Name: kelch-like 25
Synonyms: 2810402K13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207952
Homologene: 32546
Ivl
Name: involucrin
Synonyms: 1110019C06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16447
HGNC: HGNC:6187
Homologene: 137207
Or4d11
Name: olfactory receptor family 4 subfamily D member 11
Synonyms: GA_x6K02T2RE5P-2393361-2392429, MOR239-3, Olfr1423
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258675
Homologene: 128078
Serpinb12
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12
Synonyms: 2300003F07Rik, 4833409F13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71869
Homologene: 23631
Efcab3
Name: EF-hand calcium binding domain 3
Synonyms: 4921510J17Rik, Efcab15, Gm11639, Gm11639, Efcab13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108167860
Homologene: 18304
Sirpb1b
Name: signal-regulatory protein beta 1B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 668101
Homologene: 82993
Cyp2d12
Name: cytochrome P450, family 2, subfamily d, polypeptide 12
Synonyms: 9030605E09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380997
VEGA: 15
Homologene: 86099
Zfp58
Name: zinc finger protein 58
Synonyms: Mfg-1, Mfg1, A530094I17Rik, Zfp817
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238693
Pgap6
Name: post-glycosylphosphatidylinositol attachment to proteins 6
Synonyms: M83, Tmem8, Rxylt1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 60455
Homologene: 10944
Lim2
Name: lens intrinsic membrane protein 2
Synonyms: MP19, 19kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233187
HGNC: HGNC:6610
Homologene: 12744
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: PC3, prohormone convertase 1/3, Nec-1, Nec1, PC1, SPC3, Phpp-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Gtpbp2
Name: GTP binding protein 2
Synonyms: nmf205
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56055
HGNC: HGNC:4670
Homologene: 10420
Rnaseh1
Name: ribonuclease H1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19819
VEGA: 12
Homologene: 2202
Bcl11a
Name: BCL11 transcription factor A
Synonyms: mouse myeloid leukemia gene, COUP-TF interacting protein 1, CTIP1, Evi9, 2810047E18Rik, D930021L15Rik, Evi9c, Evi9b, Evi9a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14025
Homologene: 11284
Sh3tc2
Name: SH3 domain and tetratricopeptide repeats 2
Synonyms: D430044G18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225608
VEGA: 18
Homologene: 11596
Or6c65
Name: olfactory receptor family 6 subfamily C member 65
Synonyms: GA_x6K02T2PULF-11446184-11447122, MOR112-2, Olfr808
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258930
Homologene: 17438
Top1mt
Name: DNA topoisomerase 1, mitochondrial
Synonyms: 2900052H09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72960
Homologene: 43082
Slc7a12
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
Synonyms: asc-type amino acid transporter 2, Asc-2, XAT1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140918
Homologene: 76812
Tfec
Name: transcription factor EC
Synonyms: TFEC, bHLHe34, Tcfec
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21426
Homologene: 32148
Esp1
Name: exocrine gland secreted peptide 1
Synonyms: ESP1, Gm6084
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 619517
Dio3
Name: deiodinase, iodothyronine type III
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 107585
HGNC: HGNC:2885
Homologene: 1044
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 4,782,566 bp
  • A to G, chromosome 1 at 82,751,666 bp
  • T to C, chromosome 1 at 88,107,717 bp
  • A to G, chromosome 1 at 106,949,158 bp
  • A to T, chromosome 1 at 177,050,190 bp
  • T to C, chromosome 2 at 26,478,106 bp
  • T to C, chromosome 2 at 32,768,037 bp
  • G to A, chromosome 2 at 76,770,097 bp
  • G to T, chromosome 2 at 89,112,296 bp
  • A to G, chromosome 2 at 101,643,645 bp
  • A to T, chromosome 2 at 112,337,942 bp
  • T to C, chromosome 2 at 173,012,248 bp
  • A to T, chromosome 3 at 14,499,197 bp
  • A to C, chromosome 3 at 15,548,798 bp
  • T to G, chromosome 3 at 92,571,387 bp
  • A to G, chromosome 4 at 99,003,916 bp
  • T to C, chromosome 4 at 133,994,265 bp
  • A to C, chromosome 4 at 156,224,569 bp
  • C to T, chromosome 5 at 91,622,997 bp
  • C to T, chromosome 5 at 110,323,616 bp
  • A to T, chromosome 5 at 135,159,276 bp
  • T to C, chromosome 6 at 16,835,302 bp
  • T to C, chromosome 6 at 37,951,468 bp
  • A to G, chromosome 6 at 91,988,030 bp
  • T to C, chromosome 6 at 94,626,405 bp
  • T to A, chromosome 7 at 5,802,949 bp
  • T to A, chromosome 7 at 43,435,675 bp
  • T to A, chromosome 7 at 75,865,991 bp
  • T to G, chromosome 7 at 80,723,822 bp
  • G to T, chromosome 7 at 81,596,120 bp
  • A to T, chromosome 7 at 108,868,588 bp
  • T to C, chromosome 8 at 111,670,339 bp
  • T to G, chromosome 8 at 122,507,627 bp
  • G to A, chromosome 10 at 70,554,525 bp
  • A to G, chromosome 10 at 76,008,619 bp
  • T to C, chromosome 10 at 82,289,823 bp
  • T to A, chromosome 10 at 115,420,733 bp
  • A to T, chromosome 10 at 129,768,415 bp
  • T to C, chromosome 11 at 3,500,640 bp
  • C to A, chromosome 11 at 24,163,646 bp
  • T to G, chromosome 11 at 59,054,998 bp
  • G to A, chromosome 11 at 59,565,192 bp
  • A to T, chromosome 11 at 105,117,080 bp
  • T to C, chromosome 12 at 28,649,762 bp
  • G to A, chromosome 12 at 110,279,557 bp
  • A to G, chromosome 12 at 112,778,793 bp
  • T to C, chromosome 13 at 54,995,889 bp
  • T to A, chromosome 13 at 65,035,944 bp
  • T to C, chromosome 13 at 67,494,073 bp
  • T to A, chromosome 13 at 75,093,069 bp
  • G to T, chromosome 15 at 75,667,433 bp
  • A to T, chromosome 15 at 82,556,884 bp
  • A to T, chromosome 15 at 90,940,446 bp
  • A to G, chromosome 16 at 17,376,982 bp
  • A to G, chromosome 16 at 34,929,888 bp
  • T to C, chromosome 16 at 58,797,432 bp
  • A to G, chromosome 17 at 25,033,116 bp
  • C to A, chromosome 17 at 26,120,636 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • A to T, chromosome 17 at 40,728,856 bp
  • T to C, chromosome 17 at 46,168,276 bp
  • A to T, chromosome 18 at 34,438,157 bp
  • A to T, chromosome 18 at 34,498,026 bp
  • T to C, chromosome 18 at 34,793,005 bp
  • A to T, chromosome 18 at 61,977,954 bp
  • A to G, chromosome 19 at 12,036,275 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6723 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044841-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.