Strain Name:
C57BL/6J-MtgxR6734Btlr/Mmmh
Stock Number:
044852-MU
Citation ID:
RRID:MMRRC_044852-MU
Other Names:
R6734 (G1)
Major Collection:

Strain Information

Arhgef10
Name: Rho guanine nucleotide exchange factor 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234094
Homologene: 22827
Pdzd2
Name: PDZ domain containing 2
Synonyms: LOC223364, A930022H17Rik, 4930537L06Rik, Pdzk3, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Stk11ip
Name: serine/threonine kinase 11 interacting protein
Synonyms: LKB1IP, LIP1, 1200014D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71728
Homologene: 12406
Cnot2
Name: CCR4-NOT transcription complex, subunit 2
Synonyms: 2810470K03Rik, 2600016M12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72068
HGNC: HGNC:7878
Homologene: 40953
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, Depdc2, C030045D06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Ano6
Name: anoctamin 6
Synonyms: F730003B03Rik, Tmem16f, 2900059G15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Sec62
Name: SEC62 homolog, preprotein translocation
Synonyms: Dtrp1, Tloc1, 3100002M17Rik, SEC62, HTP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69276
Homologene: 2449
Naa25
Name: N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms: C330023M02Rik, 4833422K13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231713
Homologene: 6891
Klhl24
Name: kelch-like 24
Synonyms: 4930429H24Rik, 1110046J11Rik, 6530402O20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75785
VEGA: 16
Homologene: 32352
Mbd1
Name: methyl-CpG binding domain protein 1
Synonyms: Cxxc3, PCM1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17190
VEGA: 18
HGNC: HGNC:6916
Homologene: 8414
Rrp1b
Name: ribosomal RNA processing 1B
Synonyms: 2600005C20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72462
Homologene: 57086
Unc45a
Name: unc-45 myosin chaperone A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101869
Homologene: 32423
Galnt9
Name: polypeptide N-acetylgalactosaminyltransferase 9
Synonyms: GalNAc-T9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231605
HGNC: HGNC:4131
Homologene: 72793
Flrt1
Name: fibronectin leucine rich transmembrane protein 1
Synonyms: D630040I23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 396184
VEGA: 19
HGNC: HGNC:3760
Homologene: 40864
Cand1
Name: cullin associated and neddylation disassociated 1
Synonyms: 2310038O07Rik, D10Ertd516e, 6330512O03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71902
Homologene: 10202
Ppfia1
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Synonyms: liprin, C030014K08Rik, Liprin-alpha1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233977
HGNC: HGNC:9245
Homologene: 20802
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: Sema6A-1, A730020P05Rik, Semaq, sema, VIa
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20358
Homologene: 32426
Prune2
Name: prune homolog 2
Synonyms: Olfaxin, A330102H22Rik, A230083H22Rik, 6330414G02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Naa35
Name: N(alpha)-acetyltransferase 35, NatC auxiliary subunit
Synonyms: A330027C19Rik, Mak10, A330021G12Rik, C030004C14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78689
Homologene: 5781
Dennd6a
Name: DENN domain containing 6A
Synonyms: A630054L15Rik, Fam116a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211922
Homologene: 13503
Lcorl
Name: ligand dependent nuclear receptor corepressor-like
Synonyms: A830039H10Rik, Gm3414, Mlr1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041576
Homologene: 82325
Bhlhe40
Name: basic helix-loop-helix family, member e40
Synonyms: cytokine response gene 8, Clast5, Stra13, Bhlhb2, C130042M06Rik, eip1 (E47 interaction protein 1), Stra14, Sharp2, DEC1, CR8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20893
HGNC: HGNC:1046
Homologene: 2722
Tas1r3
Name: taste receptor, type 1, member 3
Synonyms: T1r3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83771
Homologene: 12890
Camk1
Name: calcium/calmodulin-dependent protein kinase I
Synonyms: Camk, CaMKIalpha, D6Ertd263e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52163
HGNC: HGNC:1459
Homologene: 117458
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71355
Homologene: 65061
Bbs1
Name: Bardet-Biedl syndrome 1
Synonyms: D19Ertd609e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52028
VEGA: 19
HGNC: HGNC:966
Homologene: 11641
Tns2
Name: tensin 2
Synonyms: nep, Tenc1, nph
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 209039
VEGA: 15
Homologene: 37077
Liph
Name: lipase, member H
Synonyms: mPA-PLA1, PLA1B, Lpdlr, LPDLR, C130037N08Rik, D16Wsu119e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239759
VEGA: 16
Homologene: 71802
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: A830008O07Rik, 1700010C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Fbn2
Name: fibrillin 2
Synonyms: Fib-2, Sne, sy
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, Megf7, mdig
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242838
Homologene: 18247
Fam227b
Name: family with sequence similarity 227, member B
Synonyms: 4930525F21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75823
Homologene: 27384
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243961
Homologene: 22949
Prpf40b
Name: pre-mRNA processing factor 40B
Synonyms: 2610317D23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54614
Homologene: 81828
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Fam149a
Name: family with sequence similarity 149, member A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212326
Homologene: 27540
Gsdma2
Name: gasdermin A2
Synonyms: Gsdm2, 2200001G21Rik, Gsdml2, 2210411P14Rik, 2210006M16Rik, 2210009F20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76758
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Ninl
Name: ninein-like
Synonyms: LOC381388, LOC381387, 4930519N13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78177
Homologene: 57024
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Zscan12
Name: zinc finger and SCAN domain containing 12
Synonyms: Zfp96
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22758
Homologene: 86980
Or9k7
Name: olfactory receptor family 9 subfamily K member 7
Synonyms: Olfr827, MOR210-5, GA_x6K02T2PULF-11878777-11877809
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258297
Homologene: 27117
Slc24a4
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Synonyms: NCKX4, A930002M03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238384
Homologene: 17798
Cyp26a1
Name: cytochrome P450, family 26, subfamily a, polypeptide 1
Synonyms: P450RA, retinoic acid hydrolase, P450RAI, RAH, Cyp26
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13082
VEGA: 19
HGNC: HGNC:2603
Homologene: 37349
Acot11
Name: acyl-CoA thioesterase 11
Synonyms: 2010309H15Rik, Thea, Them1, BFIT1, 1110020M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329910
Homologene: 11977
Trmt10c
Name: tRNA methyltransferase 10C, mitochondrial RNase P subunit
Synonyms: Rg9mtd1, D16Ertd454e, 1300018J16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52575
Homologene: 9858
Prss3l
Name: serine protease 3 like
Synonyms: Gm10334
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100040233
Homologene: 88408
Zhx3
Name: zinc fingers and homeoboxes 3
Synonyms: 1810059C13Rik, Tix1, 9530010N21Rik, 4932418O04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320799
Homologene: 9000
Dcpp2
Name: demilune cell and parotid protein 2
Synonyms: EG630537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 630537
VEGA: 17
Homologene: 103921
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 11,080,059 bp
  • T to C, chromosome 1 at 75,532,369 bp
  • G to A, chromosome 2 at 91,485,897 bp
  • A to T, chromosome 2 at 126,126,976 bp
  • C to A, chromosome 2 at 150,945,083 bp
  • T to G, chromosome 2 at 160,781,720 bp
  • A to G, chromosome 3 at 30,810,460 bp
  • C to A, chromosome 3 at 145,508,674 bp
  • C to T, chromosome 4 at 106,760,130 bp
  • C to A, chromosome 4 at 128,463,813 bp
  • T to C, chromosome 4 at 155,860,800 bp
  • A to C, chromosome 5 at 3,850,226 bp
  • A to G, chromosome 5 at 45,733,497 bp
  • G to A, chromosome 5 at 110,620,599 bp
  • C to T, chromosome 5 at 121,438,825 bp
  • T to C, chromosome 6 at 41,445,387 bp
  • TG to TGG, chromosome 6 at 108,664,857 bp
  • C to A, chromosome 6 at 113,334,384 bp
  • T to A, chromosome 7 at 19,200,507 bp
  • G to T, chromosome 7 at 44,353,686 bp
  • G to C, chromosome 7 at 80,336,998 bp
  • T to C, chromosome 7 at 144,479,053 bp
  • A to T, chromosome 8 at 14,975,053 bp
  • A to T, chromosome 8 at 45,381,441 bp
  • A to T, chromosome 9 at 109,108,920 bp
  • G to A, chromosome 10 at 116,498,153 bp
  • G to A, chromosome 10 at 119,211,992 bp
  • A to G, chromosome 10 at 130,210,257 bp
  • A to G, chromosome 11 at 98,649,590 bp
  • T to C, chromosome 12 at 102,219,000 bp
  • T to A, chromosome 13 at 21,368,796 bp
  • T to G, chromosome 13 at 59,608,191 bp
  • G to T, chromosome 14 at 26,608,619 bp
  • T to C, chromosome 15 at 12,592,465 bp
  • T to C, chromosome 15 at 71,462,780 bp
  • C to T, chromosome 15 at 76,194,403 bp
  • A to G, chromosome 15 at 95,949,536 bp
  • C to T, chromosome 15 at 99,314,903 bp
  • G to T, chromosome 15 at 102,103,116 bp
  • T to C, chromosome 16 at 20,107,529 bp
  • A to G, chromosome 16 at 21,983,957 bp
  • A to G, chromosome 16 at 56,034,126 bp
  • T to C, chromosome 17 at 23,900,571 bp
  • T to G, chromosome 17 at 32,055,304 bp
  • G to A, chromosome 18 at 47,279,169 bp
  • T to C, chromosome 18 at 58,035,960 bp
  • G to A, chromosome 18 at 74,276,043 bp
  • T to C, chromosome 19 at 4,903,896 bp
  • T to C, chromosome 19 at 7,096,159 bp
  • T to G, chromosome 19 at 17,003,733 bp
  • T to A, chromosome 19 at 37,701,212 bp
  • T to C, chromosome 19 at 56,345,509 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6734 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044852-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.