Strain Name:
C57BL/6J-MtgxR6820Btlr/Mmmh
Stock Number:
044932-MU
Citation ID:
RRID:MMRRC_044932-MU
Other Names:
R6820 (G1)
Major Collection:

Strain Information

Pak1
Name: p21 (RAC1) activated kinase 1
Synonyms: Paka, PAK-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18479
HGNC: HGNC:8590
Homologene: 1936
Pygb
Name: brain glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110078
HGNC: HGNC:9723
Homologene: 100930
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Kat7
Name: K(lysine) acetyltransferase 7
Synonyms: Hboa, Myst2, Hbo1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217127
Homologene: 5134
Exoc5
Name: exocyst complex component 5
Synonyms: Sec10l1, SEC10, PRO1912
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105504
Homologene: 38195
Psmd14
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Synonyms: Pad1, 2610312C03Rik, 3200001M20Rik, POH1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59029
Homologene: 4240
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Ubap1
Name: ubiquitin-associated protein 1
Synonyms: NAG20, 2700092A01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67123
Homologene: 9554
Smg6
Name: SMG6 nonsense mediated mRNA decay factor
Synonyms: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103677
Homologene: 23024
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Wipi2
Name: WD repeat domain, phosphoinositide interacting 2
Synonyms: 2510001I10Rik, 1110018O08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74781
Homologene: 90887
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Rbm39
Name: RNA binding motif protein 39
Synonyms: Caper alpha, 1500012C14Rik, caper, 2310040E03Rik, Rnpc2, B330012G18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170791
Homologene: 136465
Pak4
Name: p21 (RAC1) activated kinase 4
Synonyms: 5730488L07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70584
Homologene: 4300
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Chkb
Name: choline kinase beta
Synonyms: CK/EK-beta, Chetk, Chkl
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12651
HGNC: HGNC:1938
Homologene: 88718
Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Synonyms: mineralocorticoid receptor, Mlr, aldosterone receptor, MR
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110784
HGNC: HGNC:7979
Homologene: 121495
Psd
Name: pleckstrin and Sec7 domain containing
Synonyms: Psdl, Efa6, Efa6a, 1110007H17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73728
VEGA: 19
HGNC: HGNC:9507
Homologene: 31115
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Col9a3
Name: collagen, type IX, alpha 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12841
HGNC: HGNC:2219
Homologene: 20438
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Fbxw28
Name: F-box and WD-40 domain protein 28
Synonyms: Gm9337
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 668758
Homologene: 110776
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Accs
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)
Synonyms: 2610203E10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329470
Homologene: 75335
Tie1
Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Synonyms: TIE, D430008P04Rik, tie-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21846
Homologene: 3957
Or5p51
Name: olfactory receptor family 5 subfamily P member 51
Synonyms: Olfr470, GA_x6K02T2PBJ9-10175273-10174329, MOR204-22
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258417
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: GluRgamma2, KA2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76390
Homologene: 88945
Pkp3
Name: plakophilin 3
Synonyms: 2310056L12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56460
HGNC: HGNC:9025
Homologene: 5200
Wbp2nl
Name: WBP2 N-terminal like
Synonyms: PAWP, 4930521I23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74716
VEGA: 15
Homologene: 17633
Dsel
Name: dermatan sulfate epimerase-like
Synonyms: 9330132E09Rik, DS-epi2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319901
Homologene: 12964
Itih2
Name: inter-alpha trypsin inhibitor, heavy chain 2
Synonyms: Itih-2, Intin2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16425
HGNC: HGNC:6167
Homologene: 1668
Or4f54
Name: olfactory receptor family 4 subfamily F member 54
Synonyms: MOR245-11, Olfr1278, GA_x6K02T2Q125-72343713-72344654
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258389
Homologene: 74061
Fam50b
Name: family with sequence similarity 50, member B
Synonyms: D0H6S2654E, X5L, XAP-5-like
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108161
VEGA: 13
Homologene: 101669
Fbxw19
Name: F-box and WD-40 domain protein 19
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235612
Homologene: 110776
Tha1
Name: threonine aldolase 1
Synonyms: 1300017K07Rik, GLY1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71776
Homologene: 57081
Gtsf1
Name: gametocyte specific factor 1
Synonyms: 1700006H03Rik, Cue110
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74174
Homologene: 16942
Tpm2
Name: tropomyosin 2, beta
Synonyms: Trop-2, Tpm-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22004
Homologene: 134309
Nme5
Name: NME/NM23 family member 5
Synonyms: 1700019D05Rik, non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase), Nm23-M5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75533
HGNC: HGNC:7853
Homologene: 2628
Prxl2b
Name: peroxiredoxin like 2B
Synonyms: Fam213b, 2810405K02Rik, PM/PGFS
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66469
Homologene: 11976
Tmem215
Name: transmembrane protein 215
Synonyms: A930001M12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320500
Homologene: 27946
Hoxc13
Name: homeobox C13
Synonyms: N
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15422
HGNC: HGNC:5125
Homologene: 7770
Or8g51
Name: olfactory receptor family 8 subfamily G member 51
Synonyms: Olfr919, GA_x6K02T2PVTD-32400678-32399743, MOR171-23
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258432
VEGA: 9
Wdr54
Name: WD repeat domain 54
Synonyms: 1700030E05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75659
Homologene: 11382
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,211,256 bp
  • A to G, chromosome 1 at 111,859,817 bp
  • T to C, chromosome 2 at 10,098,098 bp
  • C to A, chromosome 2 at 61,776,724 bp
  • T to A, chromosome 2 at 93,842,921 bp
  • C to T, chromosome 2 at 111,293,110 bp
  • G to T, chromosome 2 at 150,816,754 bp
  • A to T, chromosome 2 at 156,179,226 bp
  • G to A, chromosome 2 at 180,607,134 bp
  • T to C, chromosome 4 at 40,473,926 bp
  • C to T, chromosome 4 at 41,379,854 bp
  • A to G, chromosome 4 at 43,518,443 bp
  • A to G, chromosome 4 at 118,484,386 bp
  • A to T, chromosome 4 at 154,898,166 bp
  • T to C, chromosome 5 at 137,407,844 bp
  • G to C, chromosome 5 at 142,629,800 bp
  • A to T, chromosome 6 at 83,154,619 bp
  • C to T, chromosome 7 at 25,046,355 bp
  • A to G, chromosome 7 at 28,563,036 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • A to G, chromosome 7 at 97,886,379 bp
  • A to G, chromosome 7 at 107,845,091 bp
  • T to C, chromosome 7 at 141,079,844 bp
  • T to C, chromosome 8 at 77,242,457 bp
  • A to G, chromosome 9 at 38,697,475 bp
  • A to T, chromosome 9 at 109,338,425 bp
  • T to A, chromosome 9 at 109,482,011 bp
  • T to C, chromosome 10 at 62,964,904 bp
  • T to C, chromosome 11 at 59,051,193 bp
  • A to G, chromosome 11 at 73,688,957 bp
  • T to C, chromosome 11 at 75,041,964 bp
  • T to C, chromosome 11 at 95,284,139 bp
  • T to C, chromosome 11 at 117,871,678 bp
  • T to C, chromosome 11 at 118,069,000 bp
  • T to C, chromosome 11 at 119,448,838 bp
  • T to C, chromosome 12 at 85,247,723 bp
  • G to A, chromosome 13 at 34,747,101 bp
  • A to G, chromosome 13 at 46,709,983 bp
  • A to T, chromosome 13 at 48,880,992 bp
  • A to T, chromosome 14 at 49,048,930 bp
  • A to G, chromosome 15 at 4,953,274 bp
  • G to T, chromosome 15 at 82,313,795 bp
  • A to G, chromosome 15 at 89,428,176 bp
  • A to G, chromosome 15 at 102,921,822 bp
  • T to C, chromosome 15 at 103,420,527 bp
  • T to C, chromosome 18 at 34,571,573 bp
  • G to T, chromosome 19 at 46,320,844 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6820 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044932-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.