Strain Name:
C57BL/6J-MtgxR6942Btlr/Mmmh
Stock Number:
045056-MU
Citation ID:
RRID:MMRRC_045056-MU
Other Names:
R6942 (G1)
Major Collection:

Strain Information

Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, Arhgap7, A730069N07Rik, STARD12
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: Cyp11b, Cyp11b-2, aldosterone synthase, steroid-11-beta-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13072
Homologene: 128035
Med13l
Name: mediator complex subunit 13-like
Synonyms: 2210413I17Rik, Trap240L, 6330591G05Rik, 9030618F05Rik, Thrap2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76199
Homologene: 25256
Sipa1l3
Name: signal-induced proliferation-associated 1 like 3
Synonyms: 2610511M17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74206
Homologene: 77938
Mtbp
Name: Mdm2, transformed 3T3 cell double minute p53 binding protein
Synonyms: MDM2BP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105837
HGNC: HGNC:7417
Homologene: 11102
Kpna6
Name: karyopherin subunit alpha 6
Synonyms: NPI-2, importin alpha 7, IPOA7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16650
HGNC: HGNC:6399
Homologene: 22472
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Mark3
Name: MAP/microtubule affinity regulating kinase 3
Synonyms: A430080F22Rik, C-TAK1, ETK-1, 1600015G02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17169
VEGA: 12
HGNC: HGNC:6897
Homologene: 55653
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Cnot9
Name: CCR4-NOT transcription complex, subunit 9
Synonyms: 2610007F23Rik, FL10, Rqcd1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 58184
Homologene: 3973
Kif2c
Name: kinesin family member 2C
Synonyms: 4930402F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73804
HGNC: HGNC:6393
Homologene: 21355
Spry1
Name: sprouty RTK signaling antagonist 1
Synonyms: sprouty1, sprouty 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24063
Homologene: 4266
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: synarfGEF, BRAG3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243621
Homologene: 46091
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: A930031B09Rik, D330024H06Rik, Ankrd15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107351
Homologene: 17706
Homer3
Name: homer scaffolding protein 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26558
Homologene: 37972
Samd8
Name: sterile alpha motif domain containing 8
Synonyms: 1110053F04Rik, Smsr, 1700010P07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67630
Homologene: 41670
Ino80
Name: INO80 complex subunit
Synonyms: Inoc1, 4632409L19Rik, INO80, 2310079N15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68142
Homologene: 75070
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: mdfw, ahl, nmf112, nmf252, 4930542A03Rik, nmf181, sals, USH1D, bob
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Atmin
Name: ATM interactor
Synonyms: gpg6, Asciz
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234776
Homologene: 35321
Large2
Name: LARGE xylosyl- and glucuronyltransferase 2
Synonyms: 5730485C17Rik, Gyltl1b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228366
Homologene: 27362
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, PKHDL1, D86 mRNA
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Gas7
Name: growth arrest specific 7
Synonyms: Gas7-cb, B230343A10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14457
HGNC: HGNC:4169
Homologene: 69015
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: Rw, LOC384168, Dpp-6, B930011P16Rik, In(5)6H-p, Peplb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Slc8a1
Name: solute carrier family 8 (sodium/calcium exchanger), member 1
Synonyms: Ncx1, D930008O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20541
VEGA: 17
Homologene: 69090
Pth1r
Name: parathyroid hormone 1 receptor
Synonyms: PPR, PTH1R, Pthr1, PTH-related peptide receptor, PTH/PTHrP receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19228
HGNC: HGNC:9608
Homologene: 267
Cog2
Name: component of oligomeric golgi complex 2
Synonyms: 2700012E02Rik, 1190002B08Rik, Cog2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76332
HGNC: HGNC:6546
Homologene: 7206
Adap2
Name: ArfGAP with dual PH domains 2
Synonyms: centaurin alpha 2, Centa2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216991
Homologene: 10179
Stat6
Name: signal transducer and activator of transcription 6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20852
Homologene: 2373
Cyp2j12
Name: cytochrome P450, family 2, subfamily j, polypeptide 12
Synonyms: OTTMUSG00000007939, Cyp2j12-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242546
HGNC: HGNC:2634
Homologene: 133195
Fktn
Name: fukutin
Synonyms: Fukutin, Fcmd
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 246179
HGNC: HGNC:3622
Homologene: 31402
Hhatl
Name: hedgehog acyltransferase-like
Synonyms: Mitsugumin 56, Mg56, 1110011D13Rik, Gup1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74770
VEGA: 9
Homologene: 19287
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218441
Homologene: 8826
Dipk1c
Name: divergent protein kinase domain 1C
Synonyms: Fam69c, B230399E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240479
Homologene: 45477
Vmn1r43
Name: vomeronasal 1 receptor 43
Synonyms: V1ra5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113847
Homologene: 130651
Or52n5
Name: olfactory receptor family 52 subfamily N member 5
Synonyms: Olfr669, MOR34-6, GA_x6K02T2PBJ9-7567376-7568329
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259045
Homologene: 72057
Grin3b
Name: glutamate receptor, ionotropic, NMDA3B
Synonyms: NR3B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 170483
Homologene: 15606
Semp2l2b
Name: SUMO/sentrin specific peptidase 2-like 2B
Synonyms: 4930444G20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 114671
Homologene: 130042
Sema6c
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
Synonyms: Semay, Sema Y
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20360
Homologene: 7931
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: 9330155G14Rik, WI-18508, Nope, WI-16786
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Map4k2
Name: mitogen-activated protein kinase kinase kinase kinase 2
Synonyms: BL44, Rab8ip
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26412
HGNC: HGNC:6864
Homologene: 3370
Tmem45a
Name: transmembrane protein 45a
Synonyms: C630002M10Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56277
Homologene: 41215
Serpinb9g
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9g
Synonyms: 1600002F03Rik, ovalbumin, NK21B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 93806
HGNC: HGNC:8955
Homologene: 69093
Tmem70
Name: transmembrane protein 70
Synonyms: 1110020A09Rik, 2210416J16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70397
Homologene: 9890
Pcdhgb5
Name: protocadherin gamma subfamily B, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93702
HGNC: HGNC:8712
Homologene: 55773
Scgb2b18
Name: secretoglobin, family 2B, member 18
Synonyms: Abpbg18, Gm4692
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043856
Homologene: 83171
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 16,677,156 bp
  • T to A, chromosome 1 at 74,518,995 bp
  • A to G, chromosome 2 at 76,901,846 bp
  • C to T, chromosome 2 at 92,370,822 bp
  • A to G, chromosome 2 at 119,383,502 bp
  • T to A, chromosome 3 at 37,643,044 bp
  • G to T, chromosome 3 at 95,173,208 bp
  • G to A, chromosome 4 at 53,735,128 bp
  • A to T, chromosome 4 at 96,112,864 bp
  • A to G, chromosome 4 at 117,166,378 bp
  • A to T, chromosome 4 at 129,651,721 bp
  • G to A, chromosome 5 at 27,469,459 bp
  • T to C, chromosome 5 at 114,191,963 bp
  • C to A, chromosome 5 at 118,745,006 bp
  • T to A, chromosome 5 at 144,784,043 bp
  • T to A, chromosome 6 at 89,870,337 bp
  • C to T, chromosome 6 at 121,473,103 bp
  • T to C, chromosome 7 at 29,386,091 bp
  • A to G, chromosome 7 at 33,172,139 bp
  • C to T, chromosome 7 at 104,938,897 bp
  • T to C, chromosome 8 at 36,938,210 bp
  • C to T, chromosome 8 at 70,291,551 bp
  • G to T, chromosome 8 at 116,956,713 bp
  • T to A, chromosome 8 at 124,545,136 bp
  • G to A, chromosome 9 at 65,120,268 bp
  • C to T, chromosome 9 at 110,728,016 bp
  • G to A, chromosome 9 at 121,788,180 bp
  • A to T, chromosome 10 at 22,067,261 bp
  • G to A, chromosome 10 at 60,438,856 bp
  • T to A, chromosome 10 at 79,976,119 bp
  • A to T, chromosome 10 at 127,651,262 bp
  • A to T, chromosome 11 at 67,660,151 bp
  • A to G, chromosome 11 at 80,155,065 bp
  • T to A, chromosome 12 at 103,122,445 bp
  • A to G, chromosome 12 at 111,592,654 bp
  • A to T, chromosome 13 at 33,494,905 bp
  • A to T, chromosome 13 at 92,516,631 bp
  • T to C, chromosome 14 at 21,775,153 bp
  • A to G, chromosome 14 at 50,836,737 bp
  • A to G, chromosome 15 at 44,522,629 bp
  • T to A, chromosome 15 at 55,567,200 bp
  • G to A, chromosome 15 at 74,856,245 bp
  • T to C, chromosome 16 at 56,825,782 bp
  • C to T, chromosome 16 at 59,539,820 bp
  • G to T, chromosome 17 at 25,385,039 bp
  • A to G, chromosome 17 at 81,408,120 bp
  • T to C, chromosome 18 at 37,732,643 bp
  • A to C, chromosome 18 at 84,730,424 bp
  • T to A, chromosome 19 at 6,346,709 bp
  • A to T, chromosome 19 at 25,424,173 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6942 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045056-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.