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Strain Name:
C57BL/6J-MtgxR7064Btlr/Mmmh
Stock Number:
045160-MU
Citation ID:
RRID:MMRRC_045160-MU
Other Names:
R7064 (G1)
Major Collection:

Strain Information

Dspp
Name: dentin sialophosphoprotein
Synonyms: Dmp3, Dpp, Dsp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666279
HGNC: HGNC:3054
Septin4
Name: septin 4
Synonyms: cell division control-related protein 2b, Pnutl2, Bh5, septin H5, Gm11492, ARTS, Sept4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18952
HGNC: HGNC:9165
Homologene: 6107
Pcdh9
Name: protocadherin 9
Synonyms: C630029H24Rik, 1500001L12Rik, LOC382930, A730003J17Rik, C530050I23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Rprd2
Name: regulation of nuclear pre-mRNA domain containing 2
Synonyms: 6720469I21Rik, 2810036A19Rik, 4930535B03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75137
Homologene: 19997
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Trmt13
Name: tRNA methyltransferase 13
Synonyms: A930028L21Rik, 4631408H19Rik, Ccdc76
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229780
Homologene: 6875
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,610,820 bp
  • C to A, chromosome 1 at 111,862,847 bp
  • A to T, chromosome 2 at 68,358,812 bp
  • T to A, chromosome 2 at 88,929,509 bp
  • T to C, chromosome 2 at 104,787,119 bp
  • T to C, chromosome 2 at 121,053,514 bp
  • C to T, chromosome 2 at 131,083,914 bp
  • T to C, chromosome 2 at 160,950,063 bp
  • G to A, chromosome 3 at 95,765,016 bp
  • T to A, chromosome 3 at 116,582,697 bp
  • T to A, chromosome 3 at 126,438,337 bp
  • C to A, chromosome 4 at 15,945,392 bp
  • C to T, chromosome 4 at 49,644,580 bp
  • C to T, chromosome 4 at 86,342,041 bp
  • T to C, chromosome 4 at 115,918,268 bp
  • A to G, chromosome 4 at 126,792,072 bp
  • T to A, chromosome 4 at 147,583,116 bp
  • C to T, chromosome 4 at 155,388,346 bp
  • A to C, chromosome 5 at 104,176,938 bp
  • T to C, chromosome 5 at 129,697,806 bp
  • A to T, chromosome 5 at 138,278,910 bp
  • T to A, chromosome 6 at 60,988,540 bp
  • T to C, chromosome 6 at 102,273,811 bp
  • A to T, chromosome 7 at 26,312,307 bp
  • G to A, chromosome 7 at 80,257,030 bp
  • A to G, chromosome 7 at 105,763,185 bp
  • C to G, chromosome 7 at 110,895,854 bp
  • T to C, chromosome 8 at 60,531,712 bp
  • T to A, chromosome 8 at 91,263,520 bp
  • A to T, chromosome 8 at 104,488,554 bp
  • A to G, chromosome 8 at 105,349,446 bp
  • T to A, chromosome 9 at 40,074,813 bp
  • A to G, chromosome 9 at 50,907,420 bp
  • T to C, chromosome 9 at 53,507,881 bp
  • C to G, chromosome 9 at 119,489,911 bp
  • A to T, chromosome 10 at 13,171,305 bp
  • T to C, chromosome 10 at 62,261,497 bp
  • G to A, chromosome 10 at 74,630,614 bp
  • T to C, chromosome 10 at 88,245,773 bp
  • A to T, chromosome 11 at 58,919,308 bp
  • A to G, chromosome 11 at 73,186,392 bp
  • A to G, chromosome 11 at 87,590,367 bp
  • T to C, chromosome 11 at 99,540,128 bp
  • A to G, chromosome 11 at 106,322,157 bp
  • T to C, chromosome 12 at 112,780,742 bp
  • T to C, chromosome 13 at 59,716,141 bp
  • C to T, chromosome 14 at 27,472,331 bp
  • T to C, chromosome 14 at 45,306,592 bp
  • C to T, chromosome 14 at 93,886,149 bp
  • G to A, chromosome 14 at 101,884,179 bp
  • T to C, chromosome 15 at 99,941,676 bp
  • A to G, chromosome 16 at 15,790,453 bp
  • A to T, chromosome 16 at 18,253,004 bp
  • A to T, chromosome 16 at 34,217,891 bp
  • T to G, chromosome 16 at 35,953,672 bp
  • T to C, chromosome 16 at 56,822,404 bp
  • T to A, chromosome 17 at 20,777,023 bp
  • T to A, chromosome 17 at 22,339,579 bp
  • G to C, chromosome 17 at 27,089,295 bp
  • T to A, chromosome 17 at 37,574,743 bp
  • T to A, chromosome 18 at 74,220,607 bp
  • T to C, chromosome 19 at 7,035,557 bp
  • A to G, chromosome 19 at 55,210,332 bp
  • T to C, chromosome 19 at 56,723,024 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7064 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045160-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.