Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7072Btlr/Mmmh
Stock Number:
045168-MU
Citation ID:
RRID:MMRRC_045168-MU
Other Names:
R7072 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Pofut2
Name: protein O-fucosyltransferase 2
Synonyms: FUT13, 2310011G23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 80294
VEGA: 10
Homologene: 12724
Slc32a1
Name: solute carrier family 32 (GABA vesicular transporter), member 1
Synonyms: R75019, VGAT, Viaat
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22348
Homologene: 56451
Btc
Name: betacellulin, epidermal growth factor family member
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12223
HGNC: HGNC:1121
Homologene: 1309
Csnk1e
Name: casein kinase 1, epsilon
Synonyms: CKI epsilon, tau, KC1epsilon, CKIepsilon, CK1epsilon
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 27373
Homologene: 121695
Ptpra
Name: protein tyrosine phosphatase receptor type A
Synonyms: RPTRalpha, PTPalpha, PTP[a], Ptpa, RPTPalpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19262
HGNC: HGNC:9664
Homologene: 20621
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 38,067,545 bp
  • G to A, chromosome 1 at 53,419,753 bp
  • A to T, chromosome 1 at 131,129,728 bp
  • G to A, chromosome 1 at 139,237,275 bp
  • T to C, chromosome 1 at 180,726,369 bp
  • T to A, chromosome 2 at 29,881,924 bp
  • C to T, chromosome 2 at 32,258,166 bp
  • A to C, chromosome 2 at 70,476,730 bp
  • T to C, chromosome 2 at 112,251,847 bp
  • A to T, chromosome 2 at 121,557,870 bp
  • T to C, chromosome 2 at 130,553,430 bp
  • C to T, chromosome 2 at 150,909,751 bp
  • T to C, chromosome 2 at 152,760,653 bp
  • A to G, chromosome 2 at 154,011,373 bp
  • T to C, chromosome 2 at 158,272,078 bp
  • T to A, chromosome 2 at 158,611,496 bp
  • A to G, chromosome 3 at 60,086,183 bp
  • T to A, chromosome 3 at 122,173,943 bp
  • A to G, chromosome 3 at 123,330,351 bp
  • T to A, chromosome 4 at 32,644,766 bp
  • C to T, chromosome 4 at 90,224,424 bp
  • A to C, chromosome 4 at 101,615,615 bp
  • A to C, chromosome 4 at 143,994,128 bp
  • A to T, chromosome 5 at 5,546,365 bp
  • T to C, chromosome 5 at 91,402,937 bp
  • A to T, chromosome 6 at 48,454,979 bp
  • A to T, chromosome 6 at 70,341,412 bp
  • T to C, chromosome 6 at 112,681,440 bp
  • A to G, chromosome 6 at 118,596,106 bp
  • A to T, chromosome 6 at 119,937,861 bp
  • C to G, chromosome 7 at 3,737,320 bp
  • A to T, chromosome 7 at 7,132,875 bp
  • A to G, chromosome 7 at 44,344,946 bp
  • A to T, chromosome 7 at 45,857,498 bp
  • A to T, chromosome 7 at 79,835,379 bp
  • A to T, chromosome 7 at 88,074,304 bp
  • A to T, chromosome 7 at 99,814,197 bp
  • A to T, chromosome 7 at 126,784,740 bp
  • T to A, chromosome 8 at 33,575,431 bp
  • A to G, chromosome 8 at 83,264,865 bp
  • T to A, chromosome 8 at 88,346,987 bp
  • T to A, chromosome 8 at 105,888,002 bp
  • T to A, chromosome 8 at 117,589,835 bp
  • T to C, chromosome 9 at 13,788,620 bp
  • A to G, chromosome 9 at 58,111,984 bp
  • T to G, chromosome 9 at 65,130,731 bp
  • G to T, chromosome 9 at 110,626,051 bp
  • T to A, chromosome 10 at 12,465,213 bp
  • A to G, chromosome 10 at 24,091,978 bp
  • A to C, chromosome 10 at 40,683,513 bp
  • A to G, chromosome 10 at 58,270,927 bp
  • T to C, chromosome 10 at 77,259,429 bp
  • A to G, chromosome 10 at 79,540,299 bp
  • G to T, chromosome 10 at 100,341,659 bp
  • T to A, chromosome 11 at 69,879,795 bp
  • G to A, chromosome 11 at 116,541,501 bp
  • T to A, chromosome 12 at 112,788,166 bp
  • T to A, chromosome 13 at 3,838,275 bp
  • T to A, chromosome 13 at 15,725,695 bp
  • T to C, chromosome 13 at 17,695,537 bp
  • T to C, chromosome 13 at 18,125,169 bp
  • C to A, chromosome 13 at 61,003,083 bp
  • T to C, chromosome 13 at 62,520,525 bp
  • G to A, chromosome 14 at 101,898,700 bp
  • C to A, chromosome 15 at 32,574,959 bp
  • C to T, chromosome 15 at 74,772,270 bp
  • T to C, chromosome 15 at 76,613,258 bp
  • C to T, chromosome 15 at 79,438,767 bp
  • A to T, chromosome 15 at 91,801,920 bp
  • A to G, chromosome 16 at 21,581,579 bp
  • A to G, chromosome 17 at 8,943,026 bp
  • A to G, chromosome 17 at 37,170,378 bp
  • G to T, chromosome 18 at 37,717,276 bp
  • A to T, chromosome 19 at 10,256,295 bp
  • T to C, chromosome 19 at 40,760,359 bp
  • A to G, chromosome 19 at 43,440,857 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7072 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045168-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.