Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7320Btlr/Mmmh
Stock Number:
045370-MU
Citation ID:
RRID:MMRRC_045370-MU
Other Names:
R7320 (G1)
Major Collection:

Strain Information

Sphk2
Name: sphingosine kinase 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56632
Homologene: 32456
Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Sema3b
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms: SemA, semaV, sema5, SemA, LUCA-1, Semaa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20347
Homologene: 20972
Rtn4rl1
Name: reticulon 4 receptor-like 1
Synonyms: Ngr3, Ngrh2, Ngrl2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237847
Homologene: 18611
Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: PTP36, C130080N23Rik, OTTMUSG00000022087
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,191,094 bp
  • G to A, chromosome 1 at 74,418,444 bp
  • G to A, chromosome 1 at 74,570,008 bp
  • A to G, chromosome 1 at 74,926,604 bp
  • A to G, chromosome 1 at 80,549,704 bp
  • A to G, chromosome 1 at 89,145,494 bp
  • G to A, chromosome 1 at 97,128,162 bp
  • T to C, chromosome 1 at 150,102,695 bp
  • G to A, chromosome 1 at 171,174,465 bp
  • T to C, chromosome 1 at 173,929,167 bp
  • A to G, chromosome 1 at 189,832,759 bp
  • A to T, chromosome 2 at 28,812,992 bp
  • A to T, chromosome 2 at 85,918,374 bp
  • GTACTTTTT to GT, chromosome 2 at 86,297,994 bp
  • A to T, chromosome 2 at 104,999,176 bp
  • A to G, chromosome 2 at 111,645,952 bp
  • A to G, chromosome 2 at 118,114,957 bp
  • A to G, chromosome 2 at 122,799,810 bp
  • A to G, chromosome 3 at 98,131,327 bp
  • T to A, chromosome 3 at 108,464,303 bp
  • C to T, chromosome 3 at 151,835,397 bp
  • A to T, chromosome 4 at 103,050,187 bp
  • G to A, chromosome 5 at 35,948,223 bp
  • T to C, chromosome 5 at 90,464,987 bp
  • C to T, chromosome 5 at 96,709,886 bp
  • T to G, chromosome 5 at 134,915,020 bp
  • T to G, chromosome 5 at 139,248,484 bp
  • C to A, chromosome 5 at 147,020,133 bp
  • T to A, chromosome 6 at 18,319,013 bp
  • T to A, chromosome 6 at 87,833,706 bp
  • T to A, chromosome 6 at 125,024,830 bp
  • C to T, chromosome 6 at 146,978,053 bp
  • A to T, chromosome 7 at 7,291,828 bp
  • T to A, chromosome 7 at 21,012,346 bp
  • T to C, chromosome 7 at 45,712,470 bp
  • G to A, chromosome 7 at 45,722,472 bp
  • C to T, chromosome 7 at 67,735,380 bp
  • G to A, chromosome 7 at 80,455,354 bp
  • C to T, chromosome 7 at 90,224,034 bp
  • C to A, chromosome 7 at 104,580,438 bp
  • T to A, chromosome 7 at 122,002,103 bp
  • A to T, chromosome 7 at 140,943,040 bp
  • A to G, chromosome 8 at 55,872,714 bp
  • G to A, chromosome 8 at 106,011,325 bp
  • A to G, chromosome 9 at 5,348,897 bp
  • A to G, chromosome 9 at 89,601,626 bp
  • T to C, chromosome 9 at 92,291,140 bp
  • T to C, chromosome 9 at 106,895,524 bp
  • T to A, chromosome 9 at 107,600,942 bp
  • A to G, chromosome 9 at 108,388,306 bp
  • A to G, chromosome 9 at 110,081,517 bp
  • G to T, chromosome 9 at 119,462,478 bp
  • A to G, chromosome 10 at 24,301,465 bp
  • A to T, chromosome 10 at 94,578,495 bp
  • T to C, chromosome 10 at 110,764,130 bp
  • A to T, chromosome 10 at 129,409,785 bp
  • C to T, chromosome 11 at 70,254,472 bp
  • A to G, chromosome 11 at 70,599,073 bp
  • T to C, chromosome 11 at 75,194,296 bp
  • A to G, chromosome 11 at 94,367,645 bp
  • T to C, chromosome 11 at 97,451,545 bp
  • C to A, chromosome 11 at 105,329,235 bp
  • A to G, chromosome 12 at 21,394,981 bp
  • T to A, chromosome 14 at 6,972,923 bp
  • A to G, chromosome 14 at 26,460,072 bp
  • A to G, chromosome 14 at 52,131,216 bp
  • A to T, chromosome 15 at 28,270,470 bp
  • A to T, chromosome 15 at 66,694,784 bp
  • A to T, chromosome 15 at 79,531,904 bp
  • A to G, chromosome 15 at 81,389,653 bp
  • A to T, chromosome 15 at 99,087,724 bp
  • T to A, chromosome 15 at 102,473,347 bp
  • T to C, chromosome 16 at 5,250,509 bp
  • C to A, chromosome 16 at 36,915,951 bp
  • A to G, chromosome 16 at 58,493,711 bp
  • G to T, chromosome 16 at 91,621,681 bp
  • A to T, chromosome 16 at 91,839,699 bp
  • A to T, chromosome 17 at 20,596,054 bp
  • T to A, chromosome 17 at 37,796,357 bp
  • A to G, chromosome 17 at 46,510,909 bp
  • T to A, chromosome 17 at 88,742,078 bp
  • G to A, chromosome 19 at 12,283,816 bp
  • T to A, chromosome 19 at 13,503,180 bp
  • C to A, chromosome 19 at 28,531,598 bp
  • T to C, chromosome 19 at 44,059,065 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7320 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045370-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.