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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7352Btlr/Mmmh
Stock Number:
045438-MU
Citation ID:
RRID:MMRRC_045438-MU
Other Names:
R7352 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: N-CoR, Rxrip13, A230020K14Rik, 5730405M06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166

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Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649

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Olig2
Name: oligodendrocyte transcription factor 2
Synonyms: RK17, Olg-2, Bhlhb1, bHLHe19
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50913
HGNC: HGNC:9398
Homologene: 4241

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Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms: alpha4 nAChR, Acra-4, Acra4, a4 nicotinic receptor, alpha4-nAChR
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11438
HGNC: HGNC:1958
Homologene: 592

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IMPC
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Ccnd1
Name: cyclin D1
Synonyms: Cyl-1, bcl-1, PRAD1, cD1, CycD1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12443
HGNC: HGNC:1582
Homologene: 1334

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
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Mouse Mine
KOMP Phenotyping
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Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Gad2
Name: glutamic acid decarboxylase 2
Synonyms: GAD65, Gad-2, 6330404F12Rik, GAD(65)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14417
HGNC: HGNC:4093
Homologene: 20223

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 15,710,611 bp
  • G to T, chromosome 1 at 30,804,326 bp
  • T to A, chromosome 1 at 39,962,227 bp
  • T to C, chromosome 1 at 132,522,399 bp
  • C to T, chromosome 1 at 156,382,477 bp
  • A to T, chromosome 1 at 176,769,857 bp
  • G to T, chromosome 1 at 188,466,124 bp
  • T to A, chromosome 2 at 22,623,823 bp
  • T to C, chromosome 2 at 65,525,701 bp
  • G to T, chromosome 2 at 69,472,397 bp
  • T to C, chromosome 2 at 70,594,750 bp
  • T to A, chromosome 2 at 72,180,091 bp
  • T to C, chromosome 2 at 76,794,484 bp
  • T to C, chromosome 2 at 85,608,784 bp
  • T to A, chromosome 2 at 88,896,718 bp
  • T to C, chromosome 2 at 89,406,462 bp
  • C to A, chromosome 2 at 89,417,967 bp
  • T to C, chromosome 2 at 167,029,513 bp
  • A to T, chromosome 2 at 181,037,474 bp
  • A to G, chromosome 3 at 89,225,280 bp
  • G to A, chromosome 3 at 92,014,640 bp
  • C to T, chromosome 3 at 104,947,177 bp
  • T to A, chromosome 4 at 40,239,668 bp
  • T to A, chromosome 4 at 83,818,023 bp
  • A to T, chromosome 4 at 120,268,251 bp
  • G to T, chromosome 4 at 128,557,636 bp
  • C to T, chromosome 4 at 129,360,081 bp
  • G to A, chromosome 4 at 155,905,711 bp
  • T to A, chromosome 5 at 31,058,078 bp
  • T to A, chromosome 5 at 32,007,250 bp
  • T to C, chromosome 5 at 86,496,542 bp
  • T to A, chromosome 5 at 88,637,194 bp
  • A to T, chromosome 5 at 94,383,884 bp
  • T to C, chromosome 5 at 112,333,268 bp
  • T to G, chromosome 5 at 117,689,641 bp
  • T to A, chromosome 5 at 119,677,560 bp
  • T to C, chromosome 5 at 144,324,626 bp
  • T to A, chromosome 5 at 145,803,688 bp
  • A to T, chromosome 6 at 11,961,638 bp
  • T to C, chromosome 6 at 24,598,111 bp
  • A to T, chromosome 6 at 34,948,279 bp
  • A to G, chromosome 6 at 38,298,981 bp
  • T to A, chromosome 6 at 41,135,495 bp
  • C to T, chromosome 6 at 78,466,859 bp
  • T to C, chromosome 6 at 87,348,118 bp
  • T to G, chromosome 6 at 92,410,890 bp
  • A to G, chromosome 7 at 19,086,072 bp
  • A to G, chromosome 7 at 19,910,616 bp
  • A to T, chromosome 7 at 79,381,680 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,926 bp
  • A to T, chromosome 7 at 134,349,394 bp
  • A to T, chromosome 7 at 140,176,525 bp
  • T to C, chromosome 7 at 144,580,659 bp
  • T to C, chromosome 7 at 144,937,387 bp
  • T to A, chromosome 8 at 12,585,742 bp
  • T to A, chromosome 8 at 45,340,997 bp
  • T to G, chromosome 8 at 71,388,881 bp
  • A to G, chromosome 9 at 3,345,796 bp
  • T to C, chromosome 9 at 39,592,925 bp
  • A to C, chromosome 9 at 40,307,993 bp
  • A to C, chromosome 9 at 53,375,722 bp
  • T to C, chromosome 9 at 67,840,446 bp
  • C to A, chromosome 9 at 107,257,070 bp
  • T to C, chromosome 9 at 111,028,450 bp
  • A to T, chromosome 10 at 10,719,493 bp
  • T to C, chromosome 10 at 58,280,698 bp
  • G to T, chromosome 10 at 70,947,900 bp
  • T to C, chromosome 10 at 75,939,836 bp
  • A to G, chromosome 11 at 62,333,911 bp
  • A to G, chromosome 11 at 78,328,812 bp
  • T to C, chromosome 11 at 80,103,343 bp
  • T to C, chromosome 11 at 101,264,418 bp
  • A to C, chromosome 11 at 102,800,452 bp
  • T to A, chromosome 11 at 119,443,579 bp
  • A to G, chromosome 12 at 88,850,293 bp
  • G to A, chromosome 12 at 101,041,832 bp
  • A to T, chromosome 12 at 111,299,311 bp
  • G to A, chromosome 13 at 70,606,102 bp
  • A to G, chromosome 14 at 31,708,041 bp
  • A to G, chromosome 14 at 59,791,204 bp
  • A to G, chromosome 14 at 66,916,421 bp
  • A to T, chromosome 15 at 8,968,358 bp
  • A to G, chromosome 15 at 27,732,876 bp
  • A to T, chromosome 15 at 76,106,418 bp
  • C to A, chromosome 15 at 76,451,474 bp
  • G to T, chromosome 15 at 76,502,824 bp
  • G to T, chromosome 15 at 84,556,980 bp
  • G to T, chromosome 15 at 89,814,456 bp
  • A to G, chromosome 15 at 100,790,984 bp
  • A to T, chromosome 16 at 10,963,353 bp
  • A to G, chromosome 16 at 32,186,216 bp
  • A to G, chromosome 16 at 91,226,689 bp
  • C to T, chromosome 17 at 24,289,054 bp
  • A to G, chromosome 17 at 25,102,069 bp
  • G to A, chromosome 17 at 46,930,426 bp
  • A to G, chromosome 17 at 56,104,427 bp
  • A to G, chromosome 17 at 57,236,944 bp
  • T to G, chromosome 18 at 20,035,335 bp
  • T to A, chromosome 18 at 37,006,845 bp
  • G to A, chromosome 18 at 37,973,278 bp
  • A to G, chromosome 19 at 12,680,751 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7352 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045438-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.