Strain Name:
C57BL/6J-MtgxR7507Btlr/Mmmh
Stock Number:
045580-MU
Citation ID:
RRID:MMRRC_045580-MU
Other Names:
R7507 (G1)
Major Collection:

Strain Information

Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Synonyms: p55alpha, p85alpha, p50alpha, PI3K
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18708
HGNC: HGNC:8979
Homologene: 7889
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: BB001228, 2510010B09Rik, Cxxc6, D10Ertd17e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Med1
Name: mediator complex subunit 1
Synonyms: l11Jus15, TRAP220, PBP, DRIP205, Pparbp, CRSP210, TRAP 220
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, Dopey1, B130005I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Utp6
Name: UTP6 small subunit processome component
Synonyms: HCA66, 4732497O03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216987
Homologene: 41265
Rnf216
Name: ring finger protein 216
Synonyms: F830018F18Rik, UIP83, Ubce7ip1, 2810055G22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108086
Homologene: 19442
Rnpc3
Name: RNA-binding region (RNP1, RRM) containing 3
Synonyms: C030014B17Rik, 2810441O16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67225
Homologene: 9746
Adam8
Name: a disintegrin and metallopeptidase domain 8
Synonyms: CD156a, MS2, CD156, E430039A18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11501
HGNC: HGNC:215
Homologene: 74384
Mgat4a
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme A
Synonyms: GnT-IVa, 9530018I07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269181
HGNC: HGNC:7047
Homologene: 8153
Clint1
Name: clathrin interactor 1
Synonyms: Epn4, C530049I24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216705
Homologene: 133740
Spag9
Name: sperm associated antigen 9
Synonyms: 3110018C07Rik, Mapk8ip4, 4831406C20Rik, syd1, JLP, 4733401I23Rik, JIP4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70834
Homologene: 2954
Adnp2
Name: ADNP homeobox 2
Synonyms: Zfp508, 8430420L05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240442
Homologene: 8945
Tubb4a
Name: tubulin, beta 4A class IVA
Synonyms: Tubb, Tubb4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22153
VEGA: 17
Homologene: 55952
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4933435G09Rik, 4930515K21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98403
Homologene: 9188
Gosr1
Name: golgi SNAP receptor complex member 1
Synonyms: GS28, GOS-28, Cis-Golgi SNARE
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53334
HGNC: HGNC:4430
Homologene: 37977
Nhlrc2
Name: NHL repeat containing 2
Synonyms: 1200003G01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66866
VEGA: 19
Homologene: 12048
Ube3d
Name: ubiquitin protein ligase E3D
Synonyms: 2610018I03Rik, Ube2cbp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70348
Homologene: 18898
Ppp1r12c
Name: protein phosphatase 1, regulatory subunit 12C
Synonyms: Mbs85, 2410197A17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232807
Homologene: 75071
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, 2310076G13Rik, ALS2CR17, A530083I02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Vasn
Name: vasorin
Synonyms: Slitl2, 2610528G05Rik, ATIA
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 246154
Homologene: 36929
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: D930026N18Rik, (alpha)1 subunit, Cchl1a1, Cav1.2, L-type Cav1.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Mlph
Name: melanophilin
Synonyms: D1Wsu84e, Slac-2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171531
Homologene: 11465
Nos3
Name: nitric oxide synthase 3, endothelial cell
Synonyms: ecNOS, 2310065A03Rik, eNOS, Nos-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18127
HGNC: HGNC:7876
Homologene: 504
Rasgrp3
Name: RAS, guanyl releasing protein 3
Synonyms: LOC240168
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240168
VEGA: 17
Homologene: 15019
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20849
Homologene: 20679
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Sgcz
Name: sarcoglycan zeta
Synonyms: C230085N17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244431
Homologene: 26726
Kif2b
Name: kinesin family member 2B
Synonyms: 1700063D03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73470
Homologene: 23775
Or6c209
Name: olfactory receptor family 6 subfamily C member 209
Synonyms: GA_x6K02T2PULF-11325750-11326685, Olfr799, MOR114-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258929
Homologene: 37000
Gria1
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1)
Synonyms: GluR-A, Glur-1, Glur1, 2900051M01Rik, GluA1, Glr1, GluR1, HIPA1, Glr-1, GluRA
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14799
HGNC: HGNC:4571
Homologene: 20226
Trim62
Name: tripartite motif-containing 62
Synonyms: Dear1, 6330414G21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67525
Homologene: 10071
Or4e2
Name: olfactory receptor family 4 subfamily E member 2
Synonyms: GA_x6K02T2RJGY-534312-533386, MOR83, Olfr1509, MOR244-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57271
HGNC: HGNC:8297
Homologene: 41378
Pnpla1
Name: patatin-like phospholipase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433091
Homologene: 25324
Plppr4
Name: phospholipid phosphatase related 4
Synonyms: PRG-1, D3Bwg0562e, Lppr4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229791
Homologene: 8895
Btnl10
Name: butyrophilin-like 10
Synonyms: Butr1, BUTR-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192194
Homologene: 138184
BC051019
Name: cDNA sequence BC051019
Synonyms: D7H11orf16, ICRFP703N2430Q5.5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57355
HGNC: HGNC:1169
Homologene: 49631
Hs3st5
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 5
Synonyms: LOC382362, D930005L05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319415
Homologene: 17796
Slc2a5
Name: solute carrier family 2 (facilitated glucose transporter), member 5
Synonyms: GLUT5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56485
Homologene: 74459
Or5w19
Name: olfactory receptor family 5 subfamily W member 19
Synonyms: GA_x6K02T2Q125-49372426-49373358, Olfr1152, MOR177-12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258103
Homologene: 79357
Sepsecs
Name: Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Synonyms: SecS, SLA, D5Ertd135e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 211006
Homologene: 15031
Zfp606
Name: zinc finger protein 606
Synonyms: 2410022M24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67370
Homologene: 23514
Zfp260
Name: zinc finger protein 260
Synonyms: PEX1, Zfp63, Ozrf1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26466
Homologene: 40802
Pcdha5
Name: protocadherin alpha 5
Synonyms: Crnr6, Cnr6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12941
HGNC: HGNC:8671
Homologene: 49565
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545848
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 33,769,759 bp
  • G to A, chromosome 1 at 37,452,527 bp
  • A to G, chromosome 1 at 52,078,574 bp
  • T to C, chromosome 1 at 60,235,467 bp
  • A to T, chromosome 1 at 90,927,707 bp
  • T to C, chromosome 2 at 87,868,369 bp
  • A to T, chromosome 3 at 113,616,761 bp
  • T to A, chromosome 3 at 117,322,105 bp
  • A to G, chromosome 4 at 128,896,871 bp
  • T to C, chromosome 4 at 150,125,650 bp
  • T to C, chromosome 5 at 24,372,644 bp
  • A to G, chromosome 5 at 52,644,055 bp
  • A to T, chromosome 5 at 143,089,802 bp
  • G to T, chromosome 6 at 69,016,693 bp
  • A to T, chromosome 6 at 119,057,239 bp
  • A to T, chromosome 6 at 121,675,218 bp
  • G to A, chromosome 7 at 4,483,971 bp
  • C to A, chromosome 7 at 12,492,941 bp
  • T to C, chromosome 7 at 30,104,866 bp
  • T to A, chromosome 7 at 109,716,268 bp
  • C to T, chromosome 7 at 139,987,178 bp
  • T to A, chromosome 8 at 37,953,046 bp
  • G to A, chromosome 9 at 86,422,886 bp
  • A to G, chromosome 9 at 86,535,949 bp
  • T to A, chromosome 10 at 36,833,015 bp
  • A to G, chromosome 10 at 62,832,892 bp
  • T to A, chromosome 10 at 129,647,497 bp
  • C to A, chromosome 11 at 45,908,949 bp
  • A to G, chromosome 11 at 57,228,939 bp
  • A to G, chromosome 11 at 58,920,558 bp
  • A to T, chromosome 11 at 76,754,414 bp
  • A to G, chromosome 11 at 79,942,186 bp
  • A to G, chromosome 11 at 91,577,443 bp
  • A to G, chromosome 11 at 94,068,080 bp
  • A to G, chromosome 11 at 98,158,026 bp
  • G to A, chromosome 13 at 101,708,982 bp
  • A to G, chromosome 14 at 52,450,473 bp
  • T to C, chromosome 16 at 4,649,481 bp
  • T to C, chromosome 17 at 28,876,817 bp
  • T to C, chromosome 17 at 57,081,642 bp
  • C to A, chromosome 17 at 75,497,060 bp
  • A to T, chromosome 18 at 36,960,856 bp
  • A to G, chromosome 18 at 80,130,853 bp
  • G to A, chromosome 19 at 56,597,378 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7507 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045580-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.