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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7571Btlr/Mmmh
Stock Number:
045711-MU
Citation ID:
RRID:MMRRC_045711-MU
Other Names:
R7571 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Ap4e1
Name: adaptor-related protein complex AP-4, epsilon 1
Synonyms: 2310033A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108011
HGNC: HGNC:573
Homologene: 22397

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Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194

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Google
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Gene Ontology
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KOMP Phenotyping
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Meis1
Name: Meis homeobox 1
Synonyms: C530044H18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17268
HGNC: HGNC:7000
Homologene: 86803

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
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ClinGen
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 1810033J14Rik, D230038D11Rik, 9530077A04Rik, Mll5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
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ClinGen
Ak4
Name: adenylate kinase 4
Synonyms: Ak-4, D4Ertd274e, Ak-3, Ak3l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11639
Homologene: 100316

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Gapdhs
Name: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Synonyms: Gapd-s, Gapds
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14447
Homologene: 101265

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 3,670,688 bp
  • T to A, chromosome 1 at 36,365,587 bp
  • A to G, chromosome 1 at 151,394,719 bp
  • T to C, chromosome 1 at 151,718,297 bp
  • G to A, chromosome 1 at 169,744,358 bp
  • A to T, chromosome 1 at 170,001,851 bp
  • C to A, chromosome 1 at 192,137,876 bp
  • T to G, chromosome 2 at 24,407,011 bp
  • T to A, chromosome 2 at 69,516,403 bp
  • T to C, chromosome 2 at 77,917,067 bp
  • C to T, chromosome 2 at 90,455,186 bp
  • C to T, chromosome 2 at 91,680,342 bp
  • C to T, chromosome 2 at 127,019,336 bp
  • A to T, chromosome 2 at 180,101,286 bp
  • A to G, chromosome 3 at 33,809,251 bp
  • T to G, chromosome 3 at 40,830,662 bp
  • A to T, chromosome 3 at 64,504,404 bp
  • T to A, chromosome 3 at 83,836,542 bp
  • G to T, chromosome 3 at 93,219,996 bp
  • G to T, chromosome 3 at 94,999,114 bp
  • G to T, chromosome 3 at 95,989,254 bp
  • A to G, chromosome 3 at 108,214,538 bp
  • G to A, chromosome 3 at 116,114,383 bp
  • T to A, chromosome 3 at 152,253,647 bp
  • T to C, chromosome 3 at 157,641,775 bp
  • C to A, chromosome 4 at 98,568,980 bp
  • T to C, chromosome 4 at 101,460,542 bp
  • A to T, chromosome 4 at 121,039,784 bp
  • T to C, chromosome 4 at 141,046,049 bp
  • T to G, chromosome 4 at 149,646,287 bp
  • G to A, chromosome 5 at 8,082,160 bp
  • T to A, chromosome 5 at 23,478,587 bp
  • C to A, chromosome 5 at 27,842,895 bp
  • A to T, chromosome 5 at 30,482,158 bp
  • T to A, chromosome 5 at 32,737,337 bp
  • A to G, chromosome 5 at 71,571,992 bp
  • C to A, chromosome 5 at 86,147,111 bp
  • A to T, chromosome 5 at 95,482,960 bp
  • G to A, chromosome 5 at 112,830,328 bp
  • A to T, chromosome 5 at 121,607,194 bp
  • T to C, chromosome 5 at 137,898,863 bp
  • A to G, chromosome 5 at 139,170,208 bp
  • A to G, chromosome 5 at 151,059,502 bp
  • T to A, chromosome 6 at 4,756,082 bp
  • A to G, chromosome 6 at 6,052,785 bp
  • G to T, chromosome 6 at 28,526,203 bp
  • T to A, chromosome 6 at 47,866,732 bp
  • A to T, chromosome 6 at 91,268,575 bp
  • G to A, chromosome 6 at 102,278,403 bp
  • T to C, chromosome 7 at 10,633,944 bp
  • A to G, chromosome 7 at 25,013,885 bp
  • A to G, chromosome 7 at 27,347,131 bp
  • G to A, chromosome 7 at 30,737,958 bp
  • G to A, chromosome 7 at 79,086,267 bp
  • T to C, chromosome 7 at 102,659,051 bp
  • A to T, chromosome 7 at 108,346,482 bp
  • A to T, chromosome 7 at 120,519,988 bp
  • C to T, chromosome 7 at 125,708,021 bp
  • T to C, chromosome 7 at 126,979,622 bp
  • G to T, chromosome 7 at 131,443,554 bp
  • A to G, chromosome 7 at 141,847,249 bp
  • A to T, chromosome 7 at 142,189,664 bp
  • A to T, chromosome 8 at 26,015,465 bp
  • T to C, chromosome 8 at 94,551,780 bp
  • A to T, chromosome 8 at 104,835,009 bp
  • A to G, chromosome 8 at 122,498,418 bp
  • A to G, chromosome 9 at 7,002,623 bp
  • T to C, chromosome 9 at 14,734,597 bp
  • T to C, chromosome 9 at 38,488,656 bp
  • T to A, chromosome 9 at 50,771,793 bp
  • T to C, chromosome 9 at 85,722,300 bp
  • A to G, chromosome 9 at 107,551,783 bp
  • A to G, chromosome 9 at 108,982,707 bp
  • T to A, chromosome 10 at 24,077,408 bp
  • A to T, chromosome 10 at 75,646,666 bp
  • G to T, chromosome 10 at 77,937,950 bp
  • T to C, chromosome 10 at 116,339,430 bp
  • A to T, chromosome 10 at 130,479,071 bp
  • A to T, chromosome 11 at 18,941,702 bp
  • A to T, chromosome 11 at 60,721,136 bp
  • A to G, chromosome 11 at 70,640,094 bp
  • A to G, chromosome 11 at 106,017,416 bp
  • C to A, chromosome 12 at 30,119,432 bp
  • C to T, chromosome 12 at 30,175,202 bp
  • T to C, chromosome 13 at 3,575,292 bp
  • T to C, chromosome 13 at 23,953,914 bp
  • T to A, chromosome 13 at 54,650,214 bp
  • T to C, chromosome 13 at 61,248,167 bp
  • T to C, chromosome 13 at 99,246,387 bp
  • A to G, chromosome 14 at 68,084,674 bp
  • A to T, chromosome 14 at 72,589,896 bp
  • T to A, chromosome 15 at 34,528,947 bp
  • T to A, chromosome 15 at 43,169,976 bp
  • C to T, chromosome 15 at 77,423,477 bp
  • T to C, chromosome 15 at 80,375,336 bp
  • T to A, chromosome 15 at 80,643,704 bp
  • A to G, chromosome 15 at 80,929,393 bp
  • A to C, chromosome 15 at 89,100,722 bp
  • A to G, chromosome 15 at 89,421,343 bp
  • T to A, chromosome 16 at 56,630,982 bp
  • T to C, chromosome 16 at 87,464,835 bp
  • G to A, chromosome 16 at 87,719,291 bp
  • T to A, chromosome 17 at 15,563,264 bp
  • T to A, chromosome 17 at 23,384,856 bp
  • T to A, chromosome 17 at 32,395,861 bp
  • T to C, chromosome 17 at 34,583,574 bp
  • T to C, chromosome 17 at 56,707,923 bp
  • C to T, chromosome 17 at 65,810,616 bp
  • T to A, chromosome 18 at 3,122,721 bp
  • T to A, chromosome 18 at 5,114,636 bp
  • T to A, chromosome 18 at 61,504,332 bp
  • A to T, chromosome 19 at 9,000,786 bp
  • T to A, chromosome 19 at 29,956,941 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7571 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045711-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.