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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7699Btlr/Mmmh
Stock Number:
045760-MU
Citation ID:
RRID:MMRRC_045760-MU
Other Names:
R7699 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Rpl13a
Name: ribosomal protein L13A
Synonyms: tum-antigen, tum-transplantation antigen P198, Tstap198-7, 1810026N22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22121
Homologene: 111053

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Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, D12Ertd7e, Dicer1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251

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Acadl
Name: acyl-Coenzyme A dehydrogenase, long-chain
Synonyms: LCAD, C79855
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11363
HGNC: HGNC:88
Homologene: 37498

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Bcl2l2
Name: BCL2-like 2
Synonyms: bclw, Gtrgal2, Gtrosa41, Bcl-w
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12050
HGNC: HGNC:995
Homologene: 2989

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App
Name: amyloid beta precursor protein
Synonyms: betaAPP, Abeta, protease nexin II, Adap, Cvap, appican, E030013M08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11820
VEGA: 16
HGNC: HGNC:620
Homologene: 56379

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
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Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: PTP36, C130080N23Rik, OTTMUSG00000022087
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
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ClinGen
Ep400
Name: E1A binding protein p400
Synonyms: p400, mDomino, 1700020J09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 10,194,411 bp
  • A to G, chromosome 1 at 43,970,466 bp
  • A to G, chromosome 1 at 66,838,363 bp
  • T to C, chromosome 1 at 134,996,032 bp
  • A to T, chromosome 1 at 154,443,928 bp
  • A to G, chromosome 1 at 170,301,148 bp
  • A to T, chromosome 1 at 189,865,411 bp
  • A to G, chromosome 1 at 192,846,867 bp
  • A to T, chromosome 2 at 13,348,178 bp
  • A to G, chromosome 2 at 13,489,917 bp
  • G to A, chromosome 2 at 53,036,508 bp
  • T to C, chromosome 2 at 72,971,229 bp
  • T to C, chromosome 2 at 73,273,380 bp
  • T to C, chromosome 2 at 97,630,679 bp
  • T to A, chromosome 2 at 120,039,716 bp
  • T to C, chromosome 2 at 121,299,720 bp
  • T to C, chromosome 2 at 121,371,748 bp
  • C to T, chromosome 2 at 155,798,176 bp
  • T to C, chromosome 2 at 156,375,406 bp
  • T to A, chromosome 2 at 161,025,943 bp
  • C to T, chromosome 2 at 180,180,861 bp
  • T to A, chromosome 3 at 36,974,172 bp
  • C to T, chromosome 3 at 37,026,154 bp
  • T to A, chromosome 3 at 64,117,115 bp
  • G to A, chromosome 3 at 90,421,804 bp
  • A to G, chromosome 3 at 95,232,597 bp
  • T to C, chromosome 3 at 96,155,963 bp
  • T to G, chromosome 3 at 107,195,540 bp
  • T to A, chromosome 3 at 130,522,479 bp
  • C to T, chromosome 3 at 145,648,692 bp
  • T to G, chromosome 4 at 26,340,758 bp
  • T to A, chromosome 4 at 32,741,344 bp
  • T to A, chromosome 4 at 51,229,335 bp
  • T to A, chromosome 4 at 105,010,454 bp
  • G to T, chromosome 4 at 108,174,077 bp
  • T to C, chromosome 4 at 115,641,965 bp
  • G to C, chromosome 4 at 121,416,679 bp
  • T to C, chromosome 4 at 124,902,647 bp
  • T to G, chromosome 4 at 130,168,039 bp
  • T to A, chromosome 4 at 139,354,870 bp
  • C to A, chromosome 4 at 139,408,867 bp
  • T to A, chromosome 4 at 145,085,405 bp
  • C to T, chromosome 4 at 150,617,098 bp
  • A to G, chromosome 5 at 23,915,496 bp
  • A to T, chromosome 5 at 26,000,180 bp
  • A to T, chromosome 5 at 72,786,024 bp
  • T to A, chromosome 5 at 77,340,421 bp
  • T to C, chromosome 5 at 97,456,398 bp
  • T to C, chromosome 5 at 104,211,724 bp
  • C to T, chromosome 5 at 110,696,032 bp
  • T to C, chromosome 5 at 122,594,560 bp
  • A to T, chromosome 5 at 136,485,739 bp
  • T to A, chromosome 5 at 137,485,176 bp
  • A to C, chromosome 5 at 138,194,657 bp
  • A to T, chromosome 5 at 142,885,749 bp
  • T to A, chromosome 5 at 150,405,327 bp
  • T to A, chromosome 6 at 18,514,735 bp
  • T to C, chromosome 6 at 40,895,388 bp
  • T to C, chromosome 6 at 43,274,757 bp
  • T to A, chromosome 6 at 48,597,822 bp
  • T to A, chromosome 6 at 48,723,857 bp
  • T to A, chromosome 6 at 65,452,956 bp
  • T to C, chromosome 6 at 115,935,239 bp
  • T to C, chromosome 6 at 115,959,794 bp
  • T to C, chromosome 6 at 120,493,427 bp
  • T to C, chromosome 6 at 123,839,923 bp
  • A to G, chromosome 7 at 10,527,632 bp
  • G to T, chromosome 7 at 16,177,556 bp
  • A to G, chromosome 7 at 24,474,267 bp
  • C to T, chromosome 7 at 25,329,928 bp
  • T to C, chromosome 7 at 28,184,312 bp
  • A to G, chromosome 7 at 29,311,607 bp
  • C to A, chromosome 7 at 41,286,407 bp
  • T to G, chromosome 7 at 45,127,236 bp
  • A to C, chromosome 7 at 45,792,574 bp
  • A to G, chromosome 7 at 102,016,822 bp
  • A to G, chromosome 7 at 102,782,322 bp
  • T to A, chromosome 7 at 104,050,593 bp
  • T to A, chromosome 7 at 108,645,672 bp
  • G to A, chromosome 7 at 120,752,618 bp
  • G to A, chromosome 7 at 141,254,929 bp
  • G to T, chromosome 8 at 4,213,989 bp
  • T to A, chromosome 8 at 33,864,363 bp
  • G to A, chromosome 8 at 40,606,884 bp
  • T to A, chromosome 8 at 41,083,969 bp
  • A to T, chromosome 8 at 64,093,954 bp
  • A to G, chromosome 8 at 108,951,122 bp
  • A to T, chromosome 9 at 13,621,089 bp
  • A to C, chromosome 9 at 37,649,475 bp
  • C to T, chromosome 9 at 57,110,654 bp
  • C to A, chromosome 9 at 90,188,739 bp
  • A to T, chromosome 9 at 95,875,690 bp
  • C to T, chromosome 9 at 108,496,172 bp
  • A to G, chromosome 9 at 108,576,361 bp
  • A to G, chromosome 9 at 110,849,554 bp
  • T to A, chromosome 10 at 67,218,416 bp
  • A to G, chromosome 10 at 77,770,635 bp
  • A to C, chromosome 10 at 82,662,288 bp
  • A to T, chromosome 10 at 85,098,249 bp
  • A to T, chromosome 10 at 85,098,515 bp
  • A to G, chromosome 10 at 100,540,369 bp
  • A to T, chromosome 10 at 120,978,090 bp
  • T to C, chromosome 10 at 129,160,055 bp
  • T to A, chromosome 11 at 8,965,142 bp
  • A to G, chromosome 11 at 49,524,554 bp
  • TCACACTCGGCACA to TCACA, chromosome 11 at 50,815,240 bp
  • A to T, chromosome 11 at 51,712,257 bp
  • A to G, chromosome 11 at 68,528,563 bp
  • A to T, chromosome 11 at 72,489,617 bp
  • T to A, chromosome 11 at 75,500,196 bp
  • T to A, chromosome 11 at 102,059,435 bp
  • A to C, chromosome 12 at 81,314,473 bp
  • A to T, chromosome 12 at 84,043,237 bp
  • G to A, chromosome 12 at 100,130,835 bp
  • A to C, chromosome 12 at 104,705,170 bp
  • A to T, chromosome 12 at 114,880,026 bp
  • T to G, chromosome 13 at 9,659,311 bp
  • C to T, chromosome 13 at 24,803,399 bp
  • G to A, chromosome 13 at 100,160,369 bp
  • C to T, chromosome 14 at 31,352,444 bp
  • G to T, chromosome 14 at 33,542,938 bp
  • C to T, chromosome 14 at 37,044,595 bp
  • T to A, chromosome 14 at 50,425,335 bp
  • A to G, chromosome 14 at 51,255,791 bp
  • C to T, chromosome 14 at 54,884,379 bp
  • G to A, chromosome 14 at 75,031,964 bp
  • T to A, chromosome 14 at 105,287,759 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • T to A, chromosome 15 at 71,973,851 bp
  • T to A, chromosome 15 at 74,835,842 bp
  • T to G, chromosome 15 at 76,090,897 bp
  • C to T, chromosome 15 at 81,586,393 bp
  • C to A, chromosome 15 at 82,064,105 bp
  • G to A, chromosome 15 at 98,843,719 bp
  • A to G, chromosome 15 at 103,462,821 bp
  • T to A, chromosome 16 at 48,842,813 bp
  • T to A, chromosome 16 at 85,040,309 bp
  • T to A, chromosome 16 at 97,448,321 bp
  • A to G, chromosome 17 at 18,073,723 bp
  • C to A, chromosome 17 at 22,375,665 bp
  • T to C, chromosome 17 at 24,880,574 bp
  • T to C, chromosome 17 at 28,167,049 bp
  • A to G, chromosome 17 at 33,002,009 bp
  • G to A, chromosome 17 at 39,644,733 bp
  • T to C, chromosome 17 at 56,103,828 bp
  • T to A, chromosome 17 at 56,601,504 bp
  • T to A, chromosome 17 at 65,265,218 bp
  • A to G, chromosome 18 at 36,931,062 bp
  • A to G, chromosome 18 at 67,225,704 bp
  • T to C, chromosome 19 at 8,890,053 bp
  • T to C, chromosome 19 at 12,322,477 bp
  • A to G, chromosome 19 at 24,942,681 bp
  • T to C, chromosome 19 at 36,089,158 bp
  • T to G, chromosome 19 at 40,249,658 bp
  • T to C, chromosome 19 at 59,344,941 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7699 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045760-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.