Strain Name:
C57BL/6J-MtgxR7839Btlr/Mmmh
Stock Number:
045893-MU
Citation ID:
RRID:MMRRC_045893-MU
Other Names:
R7839 (G1)
Major Collection:

Strain Information

Plk3
Name: polo like kinase 3
Synonyms: Cnk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12795
HGNC: HGNC:2154
Homologene: 20865
Glt8d1
Name: glycosyltransferase 8 domain containing 1
Synonyms: 2410004H05Rik, 5430414N14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76485
VEGA: 14
Homologene: 32720
Elf1
Name: E74 like ETS transcription factor 1
Synonyms: Elf-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13709
VEGA: 14
HGNC: HGNC:3316
Homologene: 7303
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 2610510B01Rik, 0610038M01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Adcyap1
Name: adenylate cyclase activating polypeptide 1
Synonyms: PACAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11516
VEGA: 17
HGNC: HGNC:241
Homologene: 869
Ppa2
Name: pyrophosphatase (inorganic) 2
Synonyms: Sid6306, 1110013G13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74776
Homologene: 134244
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: Sra-1, l(7)1Rl, P140SRA-1, E030028J09Rik, Shyc, pl-1, l7Rl1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20430
Homologene: 22628
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, Dopey1, B130005I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, 2610021O03Rik, Apc1, Mcpr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17222
Homologene: 7414
Rtf2
Name: replication termination factor 2
Synonyms: 1700067C04Rik, 5730427M17Rik, 2410001C21Rik, Rtfdc1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66404
Homologene: 9501
Trappc10
Name: trafficking protein particle complex 10
Synonyms: Tmem1, b2b2613Clo, b2b2416Clo, B230307C21Rik, LOC380642
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216131
VEGA: 10
Homologene: 37751
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Insig2
Name: insulin induced gene 2
Synonyms: Insig-2, C730043J18Rik, 2900053I11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72999
Homologene: 9400
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: 5730469D23Rik, Ube1l2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231380
Homologene: 10080
Zfp992
Name: zinc finger protein 992
Synonyms: Gm13251
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433791
Homologene: 133076
Rbm33
Name: RNA binding motif protein 33
Synonyms: 3200001K10Rik, 6430512A10Rik, Prr8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381626
Homologene: 137386
Tmt1a
Name: thiol methyltransferase 1A1
Synonyms: 2210414H16Rik, 3300001H21Rik, Mettl7a, Mettl7a1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70152
VEGA: 15
Homologene: 86842
Tob1
Name: transducer of ErbB-2.1
Synonyms: Trob, Tob
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22057
Homologene: 31334
Gzf1
Name: GDNF-inducible zinc finger protein 1
Synonyms: 8430437G08Rik, Zfp336
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74533
Homologene: 11200
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74144
Homologene: 10397
Aqp4
Name: aquaporin 4
Synonyms: aquaporin-4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11829
VEGA: 18
HGNC: HGNC:637
Homologene: 37507
Slc45a2
Name: solute carrier family 45, member 2
Synonyms: Dbr, blanc-sale, dominant brown, Oca4, Matp, Aim-1, Aim1, bls
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22293
Homologene: 9412
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Mapkapk2
Name: MAP kinase-activated protein kinase 2
Synonyms: MAPKAP kinase 2, MK2, Rps6kc1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17164
HGNC: HGNC:6887
Homologene: 56412
Rabl6
Name: RAB, member RAS oncogene family-like 6
Synonyms: B230208H17Rik, Rbel1a, Rbel1b, Rbel1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227624
Homologene: 11674
Unc13c
Name: unc-13 homolog C
Synonyms: D9Ertd414e, Munc13-3, 1500037O19Rik, Unc13h3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Gprc2a-rs2, EG637873, Casr-rs2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637873
Homologene: 129683
Gbgt1
Name: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227671
Homologene: 110677
Nlrp9b
Name: NLR family, pyrin domain containing 9B
Synonyms: Nalp9b, Nalp-delta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243874
Homologene: 18530
Degs2
Name: delta 4-desaturase, sphingolipid 2
Synonyms: Des2, 2210008A03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70059
VEGA: 12
Homologene: 23617
Abca9
Name: ATP-binding cassette, sub-family A member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Obox7
Name: oocyte specific homeobox 7
Synonyms: Gm4745
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 194588
Homologene: 44937
Sp140l2
Name: Sp140 nuclear body protein like 2
Synonyms: OTTMUSG00000029174, C130026I21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 620078
Homologene: 131208
Glis3
Name: GLIS family zinc finger 3
Synonyms: E330013K21Rik, 4833409N03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226075
Homologene: 34989
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171382
Homologene: 23433
Taar7f
Name: trace amine-associated receptor 7F
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 435207
Homologene: 134040
Bfsp1
Name: beaded filament structural protein 1, in lens-CP94
Synonyms: filensin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12075
HGNC: HGNC:1040
Homologene: 922
Nell2
Name: NEL-like 2
Synonyms: mel91, A330108N19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54003
VEGA: 15
HGNC: HGNC:7751
Homologene: 4488
Vwa5a
Name: von Willebrand factor A domain containing 5A
Synonyms: Loh11cr2a, BCSC-1, 5830475I06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67776
HGNC: HGNC:6658
Homologene: 18222
Sft2d1rt
Name: SFT2 domain containing 1, retrotransposed
Synonyms: Gm12166
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100039624
Slc6a15
Name: solute carrier family 6 (neurotransmitter transporter), member 15
Synonyms: v7-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103098
VEGA: 10
Homologene: 18163
Cyp2d22
Name: cytochrome P450, family 2, subfamily d, polypeptide 22
Synonyms: 2D22
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56448
VEGA: 15
Homologene: 75003
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Vmn1r176
Name: vomeronasal 1 receptor 176
Synonyms: Gm5998
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546943
Homologene: 128341
Cyp2j12
Name: cytochrome P450, family 2, subfamily j, polypeptide 12
Synonyms: Cyp2j12-ps, OTTMUSG00000007939
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242546
HGNC: HGNC:2634
Homologene: 133195
Or6c76b
Name: olfactory receptor family 6 subfamily C member 76B
Synonyms: Olfr813, MOR108-3, GA_x6K02T2PULF-11535078-11536010
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258252
Homologene: 138308
Cyth3
Name: cytohesin 3
Synonyms: cytohesin 3, Pscd3, Grp1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19159
HGNC: HGNC:9504
Homologene: 3116
Or10ad1
Name: olfactory receptor family 10 subfamily AD member 1
Synonyms: Olfr287, GA_x6K02T2NBG7-5548201-5549154, MOR286-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 634104
Homologene: 128379
Zfp40
Name: zinc finger protein 40
Synonyms: NTfin12, Zfp-40
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22700
Homologene: 136312
Cxcl9
Name: C-X-C motif chemokine ligand 9
Synonyms: Scyb9, Mig, crg-10, CMK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17329
HGNC: HGNC:7098
Homologene: 137210
Trbv13-2
Name: T cell receptor beta, variable 13-2
Synonyms: Tcrb-V8.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124675
Zfp383
Name: zinc finger protein 383
Synonyms: 1110003H10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73729
Homologene: 128413
Vmn2r34
Name: vomeronasal 2, receptor 34
Synonyms: ENSMUSG00000070841
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042636
Homologene: 113703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 53,567,175 bp
  • C to T, chromosome 1 at 85,247,015 bp
  • T to A, chromosome 1 at 88,326,454 bp
  • T to C, chromosome 1 at 121,312,320 bp
  • A to G, chromosome 1 at 131,097,519 bp
  • A to T, chromosome 2 at 25,592,817 bp
  • T to C, chromosome 2 at 28,503,170 bp
  • T to C, chromosome 2 at 76,708,168 bp
  • T to C, chromosome 2 at 128,684,608 bp
  • T to A, chromosome 2 at 143,831,850 bp
  • T to A, chromosome 2 at 148,683,895 bp
  • T to C, chromosome 2 at 172,466,333 bp
  • T to C, chromosome 3 at 133,376,590 bp
  • A to G, chromosome 4 at 96,099,656 bp
  • T to C, chromosome 4 at 117,129,330 bp
  • C to A, chromosome 4 at 146,466,418 bp
  • A to G, chromosome 5 at 28,368,399 bp
  • G to T, chromosome 5 at 86,122,412 bp
  • G to A, chromosome 5 at 90,263,354 bp
  • A to G, chromosome 5 at 92,328,010 bp
  • A to G, chromosome 5 at 143,697,754 bp
  • T to C, chromosome 6 at 41,121,587 bp
  • T to A, chromosome 7 at 7,684,174 bp
  • T to A, chromosome 7 at 14,665,425 bp
  • G to A, chromosome 7 at 20,024,473 bp
  • T to C, chromosome 7 at 23,834,969 bp
  • G to A, chromosome 7 at 29,915,058 bp
  • T to A, chromosome 7 at 42,266,608 bp
  • G to A, chromosome 7 at 55,886,735 bp
  • T to C, chromosome 9 at 37,410,759 bp
  • C to A, chromosome 9 at 38,723,503 bp
  • T to C, chromosome 9 at 73,933,314 bp
  • T to A, chromosome 9 at 86,542,765 bp
  • C to A, chromosome 10 at 24,050,069 bp
  • A to G, chromosome 10 at 78,188,812 bp
  • A to G, chromosome 10 at 103,404,799 bp
  • A to T, chromosome 10 at 129,857,030 bp
  • T to C, chromosome 11 at 46,052,060 bp
  • T to A, chromosome 11 at 94,213,772 bp
  • A to T, chromosome 11 at 110,134,259 bp
  • T to A, chromosome 12 at 11,457,237 bp
  • CTTAGTGAAT to CT, chromosome 12 at 108,692,201 bp
  • G to T, chromosome 14 at 31,001,831 bp
  • A to G, chromosome 14 at 79,536,415 bp
  • A to T, chromosome 15 at 11,027,749 bp
  • A to T, chromosome 15 at 76,176,383 bp
  • A to G, chromosome 15 at 82,372,571 bp
  • T to C, chromosome 15 at 95,298,938 bp
  • T to C, chromosome 15 at 98,208,145 bp
  • T to C, chromosome 15 at 100,305,076 bp
  • A to T, chromosome 16 at 93,763,941 bp
  • T to C, chromosome 17 at 23,176,989 bp
  • A to G, chromosome 17 at 93,203,985 bp
  • T to A, chromosome 18 at 15,399,680 bp
  • T to C, chromosome 19 at 28,317,373 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7839 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045893-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.