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Strain Name:
C57BL/6J-MtgxR7890Btlr/Mmmh
Stock Number:
045942-MU
Citation ID:
RRID:MMRRC_045942-MU
Other Names:
R7890 (G1)
Major Collection:

Strain Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Mtmr7
Name: myotubularin related protein 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54384
HGNC: HGNC:7454
Homologene: 99732
Rpa1
Name: replication protein A1
Synonyms: Rpa, RF-A, RP-A, 5031405K23Rik, 70kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68275
Homologene: 2208
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231326
Homologene: 71711
Prkca
Name: protein kinase C, alpha
Synonyms: Pkca
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18750
HGNC: HGNC:9393
Homologene: 55679
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: 1110037D04Rik, Lrrc16, Carmil, Lrrc16a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68732
Homologene: 9757
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 45,404,987 bp
  • T to A, chromosome 1 at 58,752,756 bp
  • A to G, chromosome 1 at 97,062,467 bp
  • A to T, chromosome 1 at 158,580,333 bp
  • A to T, chromosome 1 at 166,494,659 bp
  • C to T, chromosome 2 at 30,284,714 bp
  • T to C, chromosome 2 at 66,543,112 bp
  • A to T, chromosome 2 at 112,926,912 bp
  • T to C, chromosome 4 at 126,526,076 bp
  • T to G, chromosome 4 at 132,789,643 bp
  • G to T, chromosome 5 at 31,283,081 bp
  • T to A, chromosome 5 at 76,884,122 bp
  • T to C, chromosome 5 at 107,606,911 bp
  • T to C, chromosome 5 at 150,539,381 bp
  • T to A, chromosome 6 at 42,801,492 bp
  • T to A, chromosome 6 at 58,906,888 bp
  • G to T, chromosome 7 at 4,628,405 bp
  • T to C, chromosome 7 at 28,762,087 bp
  • G to T, chromosome 7 at 41,286,759 bp
  • C to T, chromosome 7 at 42,476,479 bp
  • A to C, chromosome 7 at 44,254,104 bp
  • G to T, chromosome 7 at 103,338,330 bp
  • T to C, chromosome 7 at 107,903,043 bp
  • A to T, chromosome 8 at 13,955,727 bp
  • A to G, chromosome 8 at 21,734,540 bp
  • T to C, chromosome 8 at 40,551,735 bp
  • T to C, chromosome 8 at 84,033,985 bp
  • G to T, chromosome 8 at 122,785,965 bp
  • T to C, chromosome 9 at 18,945,503 bp
  • T to A, chromosome 9 at 36,120,995 bp
  • C to T, chromosome 9 at 39,820,014 bp
  • C to A, chromosome 9 at 64,322,471 bp
  • G to A, chromosome 10 at 74,642,314 bp
  • A to G, chromosome 11 at 4,074,795 bp
  • T to C, chromosome 11 at 16,995,238 bp
  • C to A, chromosome 11 at 17,211,443 bp
  • C to T, chromosome 11 at 51,234,838 bp
  • C to G, chromosome 11 at 54,626,723 bp
  • A to G, chromosome 11 at 66,072,072 bp
  • C to A, chromosome 11 at 69,026,529 bp
  • CA to C, chromosome 11 at 75,307,224 bp
  • T to A, chromosome 11 at 99,936,551 bp
  • A to T, chromosome 11 at 108,012,684 bp
  • T to A, chromosome 11 at 114,686,446 bp
  • A to T, chromosome 12 at 72,940,543 bp
  • T to C, chromosome 12 at 76,873,450 bp
  • C to T, chromosome 12 at 109,592,817 bp
  • T to C, chromosome 13 at 13,740,569 bp
  • A to T, chromosome 13 at 24,013,232 bp
  • T to C, chromosome 13 at 67,491,995 bp
  • T to G, chromosome 13 at 76,827,757 bp
  • T to A, chromosome 13 at 96,831,871 bp
  • A to G, chromosome 14 at 28,040,341 bp
  • A to T, chromosome 15 at 66,683,814 bp
  • A to G, chromosome 15 at 85,066,328 bp
  • A to T, chromosome 15 at 91,847,076 bp
  • C to T, chromosome 16 at 34,963,648 bp
  • T to A, chromosome 16 at 92,499,387 bp
  • A to T, chromosome 17 at 18,929,540 bp
  • T to A, chromosome 17 at 74,437,508 bp
  • T to C, chromosome 18 at 33,185,005 bp
  • T to A, chromosome 19 at 33,501,564 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7890 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045942-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.