Strain Name:
C57BL/6J-MtgxR8004Btlr/Mmmh
Stock Number:
046044-MU
Citation ID:
RRID:MMRRC_046044-MU
Other Names:
R8004 (G1)
Major Collection:

Strain Information

Npl
Name: N-acetylneuraminate pyruvate lyase
Synonyms: 0610033B02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74091
Homologene: 12533
Tjp2
Name: tight junction protein 2
Synonyms: ZO-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21873
VEGA: 19
Homologene: 3541
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF kappaB1, p50 subunit of NF kappaB, p50/p105, p50, nuclear factor kappaB p50, NF-kappaB, NF-kappaB p50
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Rbm25
Name: RNA binding motif protein 25
Synonyms: 2610015J01Rik, A130095G20Rik, 2600011C06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67039
Mllt6
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms: Af17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246198
HGNC: HGNC:7138
Homologene: 31347
Sar1a
Name: secretion associated Ras related GTPase 1A
Synonyms: 1600019H17Rik, Sara1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20224
VEGA: 10
Homologene: 90897
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Setd2
Name: SET domain containing 2
Synonyms: 4921524K10Rik, KMT3A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235626
Homologene: 56493
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218503
VEGA: 13
Homologene: 9030
Tnpo2
Name: transportin 2 (importin 3, karyopherin beta 2b)
Synonyms: Kpnb2b, TRN2, 1110034O24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212999
Homologene: 8381
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Psmd9
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Synonyms: P27, 1500011J20Rik, Bridge-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67151
HGNC: HGNC:9567
Homologene: 2106
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, 2310003F20Rik, Tulip1, Garnl1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Igf2bp3
Name: insulin-like growth factor 2 mRNA binding protein 3
Synonyms: 2610101N11Rik, IMP3, Koc13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140488
Homologene: 4773
Msh6
Name: mutS homolog 6
Synonyms: Msh6, GTBP, Gtmbp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17688
VEGA: 17
HGNC: HGNC:7329
Homologene: 149
Sp3
Name: trans-acting transcription factor 3
Synonyms: D130027J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20687
Homologene: 7952
Tnc
Name: tenascin C
Synonyms: Hxb, TN-C, TN, C130033P17Rik, tenascin-C, cytotactin, hexabrachion
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Cdan1
Name: codanin 1
Synonyms: CDA-I, CDA1, 1500015A01Rik, codanin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68968
HGNC: HGNC:1713
Homologene: 16324
Lrrn2
Name: leucine rich repeat protein 2, neuronal
Synonyms: NLRR-2, 5730406J09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16980
Homologene: 21274
Tbc1d10b
Name: TBC1 domain family, member 10b
Synonyms: 1110003P22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68449
Homologene: 9177
Nol12
Name: nucleolar protein 12
Synonyms: C78541, Nop25
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 97961
Homologene: 32577
Tmem184b
Name: transmembrane protein 184b
Synonyms: 4732495E13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223693
VEGA: 15
HGNC: HGNC:1310
Homologene: 6396
Parm1
Name: prostate androgen-regulated mucin-like protein 1
Synonyms: 2210012L08Rik, 9130213B05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231440
Homologene: 41036
Slc35f5
Name: solute carrier family 35, member F5
Synonyms: 1300003P13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74150
Homologene: 5745
Atp6v0a4
Name: ATPase, H+ transporting, lysosomal V0 subunit A4
Synonyms: V-ATPase alpha 4, Atp6n1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140494
HGNC: HGNC:866
Homologene: 39904
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: Ae3, A930038D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20536
Homologene: 129474
Cngb3
Name: cyclic nucleotide gated channel beta 3
Synonyms: CNG6, CCNC2, Cngbeta2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30952
HGNC: HGNC:2153
Homologene: 40908
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Abcb11
Name: ATP-binding cassette, sub-family B member 11
Synonyms: PFIC2, ABC16, PGY4, Lith1, sister of P-glycoprotein, Bsep
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Vmn1r58
Name: vomeronasal 1 receptor 58
Synonyms: V3R4, V1rd4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81014
Homologene: 41799
Myo1h
Name: myosin 1H
Synonyms: 4631401O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231646
Homologene: 82639
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Or5k3
Name: olfactory receptor family 5 subfamily K member 3
Synonyms: GA_x54KRFPKG5P-55369823-55370749, MOR184-5, Olfr195
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259000
Homologene: 128109
Cfap251
Name: cilia and flagella associated protein 251
Synonyms: 4930415N18Rik, 4933428F06Rik, Wdr66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269701
Homologene: 16964
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: SMC1beta, Smc1l2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
Chrm2
Name: cholinergic receptor, muscarinic 2, cardiac
Synonyms: M2, AChR M2, muscarinic acetylcholine receptor 2, Chrm-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243764
HGNC: HGNC:1951
Homologene: 20190
Tex10
Name: testis expressed gene 10
Synonyms: clone 18330, 2810462N03Rik, 2610206N19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269536
Homologene: 32361
Cyp2b23
Name: cytochrome P450, family 2, subfamily b, polypeptide 23
Synonyms: EG243881
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243881
HGNC: HGNC:2615
Homologene: 117483
Ankrd24
Name: ankyrin repeat domain 24
Synonyms: 5730519E19Rik, 4631433D01Rik, D10Bur2e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70615
Homologene: 49885
Nfatc2ip
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
Synonyms: NIP45, D7Ertd304e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18020
Homologene: 7862
Plscr4
Name: phospholipid scramblase 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235527
Homologene: 23217
Rbm44
Name: RNA binding motif protein 44
Synonyms: LOC329207
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329207
Homologene: 66636
Ldlrad1
Name: low density lipoprotein receptor class A domain containing 1
Synonyms: OTTMUSG00000008594
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546840
Homologene: 54473
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: THAM, Dpp-4, Cd26
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Il18r1
Name: interleukin 18 receptor 1
Synonyms: Il1rrp, Il18ralpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16182
HGNC: HGNC:5988
Homologene: 2861
Pcsk4
Name: proprotein convertase subtilisin/kexin type 4
Synonyms: PC4, SPC5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18551
HGNC: HGNC:8746
Homologene: 22495
Fbxw20
Name: F-box and WD-40 domain protein 20
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434440
Homologene: 110776
Bpifc
Name: BPI fold containing family C
Synonyms: Bpil2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270757
Homologene: 18383
Bbs2
Name: Bardet-Biedl syndrome 2
Synonyms: 2410125H22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67378
HGNC: HGNC:967
Homologene: 12122
St6galnac5
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Synonyms: ST6GalNAc V, Siat7e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26938
Homologene: 8079
Dipk1a
Name: divergent protein kinase domain 1A
Synonyms: 2900024C23Rik, Fam69a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67266
Homologene: 12104
Gm904
Name: predicted gene 904
Synonyms: LOC380845, LOC382165
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380845
Homologene: 134520
Igkv1-99
Name: immunoglobulin kappa variable 1-99
Synonyms: Gm16800
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434028
S100a6
Name: S100 calcium binding protein A6 (calcyclin)
Synonyms: Cacy, CALCYCLIN, 5B10, 2A9, PRA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20200
Homologene: 7925
Or7e171-ps1
Name: olfactory receptor family 7 subfamily E member 171, pseudogene 1
Synonyms: GA_x6K02T2PVTD-13682249-13681321, MOR146-5P, MOR146-11_p, Olfr863-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258070
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,951,062 bp
  • G to A, chromosome 1 at 40,474,757 bp
  • T to C, chromosome 1 at 75,549,067 bp
  • T to A, chromosome 1 at 91,152,158 bp
  • A to T, chromosome 1 at 125,589,887 bp
  • T to A, chromosome 1 at 132,937,751 bp
  • T to A, chromosome 1 at 153,503,540 bp
  • A to G, chromosome 2 at 62,358,828 bp
  • T to A, chromosome 2 at 69,257,210 bp
  • A to T, chromosome 2 at 72,970,208 bp
  • T to C, chromosome 2 at 118,417,294 bp
  • C to T, chromosome 2 at 120,731,443 bp
  • A to G, chromosome 3 at 59,329,709 bp
  • T to C, chromosome 3 at 90,613,812 bp
  • C to A, chromosome 3 at 135,591,551 bp
  • A to T, chromosome 3 at 152,840,165 bp
  • A to G, chromosome 4 at 19,505,273 bp
  • T to C, chromosome 4 at 48,452,047 bp
  • G to A, chromosome 4 at 63,984,657 bp
  • G to A, chromosome 4 at 107,209,491 bp
  • A to T, chromosome 4 at 144,194,251 bp
  • A to C, chromosome 5 at 91,594,273 bp
  • T to C, chromosome 5 at 107,909,666 bp
  • A to T, chromosome 5 at 114,320,708 bp
  • T to C, chromosome 5 at 123,241,935 bp
  • T to C, chromosome 5 at 123,254,450 bp
  • T to A, chromosome 6 at 36,523,286 bp
  • A to T, chromosome 6 at 38,050,549 bp
  • C to A, chromosome 6 at 49,091,020 bp
  • T to C, chromosome 6 at 68,542,128 bp
  • T to A, chromosome 6 at 132,657,427 bp
  • A to T, chromosome 7 at 5,410,507 bp
  • G to T, chromosome 7 at 26,679,466 bp
  • A to G, chromosome 7 at 126,390,405 bp
  • T to A, chromosome 7 at 127,199,011 bp
  • T to C, chromosome 8 at 85,044,699 bp
  • A to G, chromosome 8 at 94,082,490 bp
  • T to C, chromosome 8 at 95,752,752 bp
  • A to T, chromosome 9 at 19,942,112 bp
  • T to A, chromosome 9 at 79,684,401 bp
  • C to T, chromosome 9 at 92,490,790 bp
  • G to T, chromosome 9 at 109,221,381 bp
  • G to A, chromosome 9 at 110,592,545 bp
  • C to A, chromosome 10 at 61,685,166 bp
  • T to C, chromosome 10 at 80,322,840 bp
  • T to A, chromosome 10 at 81,638,357 bp
  • T to G, chromosome 10 at 85,979,284 bp
  • G to T, chromosome 11 at 97,676,140 bp
  • A to G, chromosome 11 at 115,982,705 bp
  • A to G, chromosome 12 at 55,702,457 bp
  • A to T, chromosome 12 at 83,674,392 bp
  • C to G, chromosome 12 at 87,960,151 bp
  • G to A, chromosome 13 at 50,645,307 bp
  • T to A, chromosome 13 at 98,789,505 bp
  • A to T, chromosome 15 at 78,940,517 bp
  • A to G, chromosome 15 at 79,362,766 bp
  • G to A, chromosome 15 at 85,097,614 bp
  • T to A, chromosome 16 at 59,148,988 bp
  • A to G, chromosome 17 at 35,266,696 bp
  • A to G, chromosome 17 at 84,192,205 bp
  • A to G, chromosome 17 at 87,986,787 bp
  • G to A, chromosome 19 at 24,114,120 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8004 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046044-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.