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Availability & Fees Order this Strain
Depending on the type of Cre employed, this strain will lack endogenous expression of Rbpj in the specific tissue where Cre is expressed. Instead, it will allow for the doxycycline-dependent expression of an Rbpj transgene. Thus, this mouse strain will allow for the tissue- and temporal-specific regulation of Notch signaling responsiveness in cells.
Conditional phenotype: Conditional deletion of endogenous Rbpj and inducible expression of transgenic Rbpj.
To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.
The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.
Chen ELY, Thompson PK, Zúñiga-Pflücker JC. RBPJ-dependent Notch signalinginitiates the T cell program in a subset of thymus-seeding progenitors. NatImmunol. 2019 Nov;20(11):1456-1468. doi: 10.1038/s41590-019-0518-7. Epub 2019 Oct21. (Medline PMID: 31636466)
Han H, Tanigaki K, Yamamoto N, Kuroda K, Yoshimoto M, Nakahata T, Ikuta K, Honjo T. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol. 2002 Jun;14(6):637-45. (Medline PMID: 12039915)
Stadtfeld M, Graf T. Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development. 2005 Jan;132(1):203-13. Epub 2004 Dec 2. (Medline PMID: 15576407)
Belteki G, Haigh J, Kabacs N, Haigh K, Sison K, Costantini F, Whitsett J,Quaggin SE, Nagy A. Conditional and inducible transgene expression in micethrough the combinatorial use of Cre-mediated recombination and tetracyclineinduction. Nucleic Acids Res. 2005 Mar 22;33(5):e51. Erratum in: Nucleic AcidsRes. 2005;33(8):2765. (Medline PMID: 15784609)
Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain's tissue samples taken when archived by or ordered from the assigned MMRRC Center.
Colony Surveillance Program and Current Health Reports
The availability level for this product has not been determined.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The submitter or their institution limits the distribution to non-profit institutions only.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.
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