Strain Name:
C57BL/6J-MtgxR8118Btlr/Mmmh
Stock Number:
067547-MU
Citation ID:
RRID:MMRRC_067547-MU
Other Names:
R8118 (G1)
Major Collection:

Strain Information

Ippk
Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms: 1810043M15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75678
VEGA: 13
Homologene: 41495
Cdk17
Name: cyclin dependent kinase 17
Synonyms: 6430598J10Rik, Pctk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237459
VEGA: 10
HGNC: HGNC:8750
Homologene: 55666
Sfrp1
Name: secreted frizzled-related protein 1
Synonyms: 2210415K03Rik, sFRP-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20377
Homologene: 2266
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Mtfp1
Name: mitochondrial fission process 1
Synonyms: Mtp18, 1700020C11Rik, 2610507A21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67900
Homologene: 32318
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Ints3
Name: integrator complex subunit 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229543
Homologene: 11309
Exoc4
Name: exocyst complex component 4
Synonyms: Sec8, Sec8l1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20336
Homologene: 40654
Cobl
Name: cordon-bleu WH2 repeat
Synonyms: C530045F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12808
Homologene: 9058
Sf3a2
Name: splicing factor 3a, subunit 2
Synonyms: 66kDa, SFA66, PRP11, Sap62
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20222
Homologene: 133823
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: 5033413A03Rik, SRm300
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75956
Scaf8
Name: SR-related CTD-associated factor 8
Synonyms: A930036P18Rik, Rbm16, A630086M08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106583
VEGA: 17
Homologene: 8928
Mnat1
Name: menage a trois 1
Synonyms: MAT1, E130115E11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17420
HGNC: HGNC:7181
Homologene: 1821
Map2
Name: microtubule-associated protein 2
Synonyms: repro4, G1-397-34, MAP-2, Mtap2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Nelfb
Name: negative elongation factor complex member B
Synonyms: Cobra1, A730008L03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58202
Homologene: 121600
Usp33
Name: ubiquitin specific peptidase 33
Synonyms: Vdu1, 9830169D19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170822
Homologene: 8996
Klhl20
Name: kelch-like 20
Synonyms: D930050H05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226541
Homologene: 8699
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Tmem204
Name: transmembrane protein 204
Synonyms: Clp24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 407831
Homologene: 36419
Ttn
Name: titin
Synonyms: connectin, 1100001C23Rik, D330041I19Rik, D830007G01Rik, 2310074I15Rik, 2310036G12Rik, mdm, 2310057K23Rik, shru, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC382129, LOC234973, 9430076A06Rik, D430038H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Mlxipl
Name: MLX interacting protein-like
Synonyms: bHLHd14, Wbscr14, ChREBP, WS-bHLH
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58805
Homologene: 32507
Or2t6
Name: olfactory receptor family 2 subfamily T member 6
Synonyms: MOR274-2, GA_x6K02T2PLTE-6544896-6543946, Olfr720
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258387
Homologene: 74036
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: N-3 kinesin, Kif16a, E230025N21Rik, 4831403C07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: X83337, 1810073P09Rik, ESTM15
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75607
Homologene: 19155
Tbc1d17
Name: TBC1 domain family, member 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233204
Homologene: 11656
Map3k10
Name: mitogen-activated protein kinase kinase kinase 10
Synonyms: mixed lineage kinase 2, serine/threonine kinase, MKN28 derived nonreceptor_type, MKN28 kinase, Mlk2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269881
HGNC: HGNC:6849
Homologene: 1834
Or14a258
Name: olfactory receptor family 14 subfamily A member 258
Synonyms: Olfr304, GA_x6K02T2NHDJ-9721756-9722757, MOR219-3P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258089
Homologene: 121542
Arhgef11
Name: Rho guanine nucleotide exchange factor 11
Synonyms: Prg, PDZ-RhoGEF
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213498
Homologene: 11409
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230622
Homologene: 135888
Nlrc3
Name: NLR family, CARD domain containing 3
Synonyms: Caterpiller 16.2, D230007K08Rik, CLR16.2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268857
Homologene: 18720
Nebl
Name: nebulette
Synonyms: 1200007O21Rik, A630080F05Rik, Lnebl, D830029A09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74103
Homologene: 128431
Itgal
Name: integrin alpha L
Synonyms: Ly-15, Ly-21, Cd11a, LFA-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Fbxo47
Name: F-box protein 47
Synonyms: LOC380724, 2900052P03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72973
Homologene: 47677
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210274
Homologene: 105965
Svs3b
Name: seminal vesicle secretory protein 3B
Synonyms: 9530004A22Rik, SVS III
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329557
Homologene: 110771
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100559
Homologene: 137225
Or5g29
Name: olfactory receptor family 5 subfamily G member 29
Synonyms: GA_x6K02T2Q125-47069356-47070300, MOR175-5, Olfr998
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258428
Homologene: 74236
Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif 1
Synonyms: ADAMTS-1, METH-1, ADAM-TS1, METH1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: Tj6, 8430408C20Rik, Atp6n2, V-ATPase a2, ATP6a2, TJ6s
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21871
Homologene: 56523
Large1
Name: LARGE xylosyl- and glucuronyltransferase 1
Synonyms: froggy, enr, BPFD#36, fg
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16795
HGNC: HGNC:6511
Homologene: 7810
Adcy7
Name: adenylate cyclase 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11513
HGNC: HGNC:238
Homologene: 866
Palm3
Name: paralemmin 3
Synonyms: 4432412L15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74337
Homologene: 53493
Or5b123
Name: olfactory receptor family 5 subfamily B member 123
Synonyms: MOR202-18, GA_x6K02T2RE5P-3951719-3952666, Olfr1487
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258629
Homologene: 110492
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Cimap2
Name: ciliary microtubule associated protein 2
Synonyms: BC055111, Lexm
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242602
Homologene: 17630
Vmn2r20
Name: vomeronasal 2, receptor 20
Synonyms: EG667180
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 667180
Homologene: 84037
Mcmdc2
Name: minichromosome maintenance domain containing 2
Synonyms: 6030422M02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240697
Homologene: 18309
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76179
Homologene: 44504
Ankle1
Name: ankyrin repeat and LEM domain containing 1
Synonyms: 8430438L13Rik, Ankrd41
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234396
Homologene: 17562
Or4k15b
Name: olfactory receptor family 4 subfamily K member 15B
Synonyms: GA_x6K02T2PMLR-5725741-5724776, MOR246-3, Olfr725, MOR246-7_p
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258314
Homologene: 44957
Ttll10
Name: tubulin tyrosine ligase-like family, member 10
Synonyms: Ttll5, 4833412E22Rik, 4930595O22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 330010
Homologene: 51912
Or1ad8
Name: olfactory receptor family 1 subfamily AD member 8
Synonyms: Olfr51, GA_x6K02T2QP88-4431129-4430206, MOR129-3, ID7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18351
Homologene: 133578
Prps1l1
Name: phosphoribosyl pyrophosphate synthetase 1-like 1
Synonyms: 1700011K15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75456
HGNC: HGNC:9463
Homologene: 75282
Gm7030
Name: predicted gene 7030
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 630294
Homologene: 133121
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Hs3st2
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 2
Synonyms: A830061E14Rik, 6430516N12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 195646
HGNC: HGNC:5195
Homologene: 21220
Tex29
Name: testis expressed 29
Synonyms: 1700018L24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75528
Rgs7bp
Name: regulator of G-protein signalling 7 binding protein
Synonyms: D13Bwg1146e, R7bp, A930030I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 52882
VEGA: 13
Homologene: 78705
Gpr61
Name: G protein-coupled receptor 61
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229714
Homologene: 12910
Tubg2
Name: tubulin, gamma 2
Synonyms: Tubgl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103768
Homologene: 69216
Gm2888
Name: predicted gene 2888
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100040657
Homologene: 115686
Agr2
Name: anterior gradient 2
Synonyms: Gob-4, mAG-2, HAG-2, XAG-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23795
HGNC: HGNC:328
Homologene: 4674
Krtap4-13
Name: keratin associated protein 4-13
Synonyms: 2300006N05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69464
Homologene: 124486
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 9,916,374 bp
  • A to T, chromosome 1 at 66,425,391 bp
  • A to T, chromosome 1 at 161,098,401 bp
  • T to A, chromosome 2 at 17,379,820 bp
  • A to T, chromosome 2 at 25,205,159 bp
  • T to A, chromosome 2 at 76,747,164 bp
  • T to A, chromosome 2 at 85,590,988 bp
  • G to A, chromosome 2 at 120,704,430 bp
  • A to G, chromosome 2 at 164,256,006 bp
  • A to T, chromosome 3 at 86,354,226 bp
  • T to C, chromosome 3 at 87,735,857 bp
  • C to T, chromosome 3 at 90,400,299 bp
  • A to G, chromosome 3 at 108,150,572 bp
  • T to C, chromosome 3 at 152,360,359 bp
  • T to A, chromosome 4 at 106,613,398 bp
  • T to C, chromosome 4 at 112,865,675 bp
  • A to C, chromosome 4 at 113,156,494 bp
  • G to A, chromosome 4 at 156,044,762 bp
  • T to C, chromosome 5 at 87,423,771 bp
  • C to T, chromosome 5 at 121,286,376 bp
  • T to C, chromosome 5 at 124,712,773 bp
  • T to G, chromosome 5 at 135,137,248 bp
  • T to C, chromosome 6 at 33,971,918 bp
  • T to A, chromosome 6 at 35,230,516 bp
  • A to T, chromosome 6 at 123,396,470 bp
  • A to G, chromosome 7 at 27,673,417 bp
  • G to T, chromosome 7 at 44,843,002 bp
  • A to T, chromosome 7 at 86,385,768 bp
  • C to T, chromosome 7 at 121,397,428 bp
  • T to C, chromosome 7 at 121,677,262 bp
  • C to A, chromosome 7 at 127,311,245 bp
  • A to T, chromosome 7 at 144,409,875 bp
  • A to T, chromosome 8 at 11,854,263 bp
  • T to G, chromosome 8 at 23,411,984 bp
  • T to C, chromosome 8 at 71,407,635 bp
  • A to G, chromosome 8 at 73,131,944 bp
  • A to G, chromosome 8 at 84,029,809 bp
  • A to G, chromosome 8 at 88,315,756 bp
  • A to G, chromosome 9 at 15,960,104 bp
  • T to C, chromosome 10 at 80,803,640 bp
  • C to A, chromosome 10 at 93,216,390 bp
  • C to T, chromosome 10 at 128,722,449 bp
  • A to G, chromosome 11 at 4,093,910 bp
  • A to G, chromosome 11 at 12,254,834 bp
  • A to G, chromosome 11 at 51,007,500 bp
  • C to T, chromosome 11 at 97,879,515 bp
  • C to T, chromosome 11 at 99,809,398 bp
  • A to G, chromosome 11 at 101,161,478 bp
  • C to A, chromosome 12 at 34,985,341 bp
  • A to G, chromosome 12 at 35,996,107 bp
  • A to G, chromosome 12 at 73,219,090 bp
  • A to T, chromosome 12 at 112,601,437 bp
  • A to G, chromosome 13 at 49,090,983 bp
  • C to T, chromosome 13 at 49,446,342 bp
  • C to A, chromosome 13 at 105,053,121 bp
  • G to T, chromosome 14 at 3,037,628 bp
  • A to G, chromosome 14 at 14,175,863 bp
  • G to A, chromosome 14 at 33,104,115 bp
  • T to C, chromosome 14 at 50,035,151 bp
  • T to A, chromosome 16 at 3,965,631 bp
  • T to C, chromosome 16 at 85,795,933 bp
  • T to A, chromosome 17 at 3,164,183 bp
  • T to A, chromosome 17 at 23,808,083 bp
  • T to C, chromosome 17 at 25,080,338 bp
  • C to T, chromosome 17 at 36,127,690 bp
  • C to T, chromosome 18 at 20,032,274 bp
  • A to G, chromosome 18 at 20,582,801 bp
  • T to A, chromosome 19 at 13,619,745 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8118 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067547-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.