Strain Name:
C57BL/6J-MtgxR8157Btlr/Mmmh
Stock Number:
067583-MU
Citation ID:
RRID:MMRRC_067583-MU
Other Names:
R8157 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: Ptprz, Ptpz, Rptpbeta, RPTPz, DSD-1-PG, PTPbeta, phosphacan, PTPzeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Scrib
Name: scribbled planar cell polarity
Synonyms: Crc, Scrb1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Zbtb7c
Name: zinc finger and BTB domain containing 7C
Synonyms: Kr-pok, B230208J24Rik, Zbtb36
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 207259
VEGA: 18
Homologene: 17070
Ephx2
Name: epoxide hydrolase 2, cytoplasmic
Synonyms: Eph2, sEH, sEP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13850
VEGA: 14
HGNC: HGNC:3402
Homologene: 37558
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 1700017E21Rik, 4933439E17Rik, 4933438D16Rik, D14Ertd581e, 4930513H15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52023
VEGA: 14
Homologene: 4628
Eprs1
Name: glutamyl-prolyl-tRNA synthetase 1
Synonyms: Qprs, 3010002K18Rik, 2410081F06Rik, Eprs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 1700066F09Rik, 2310028E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208846
VEGA: 12
Homologene: 36635
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, opm, A630086P08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Atg2b
Name: autophagy related 2B
Synonyms: C630028L02Rik, 2410024A21Rik, C030004M05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Lamb2
Name: laminin, beta 2
Synonyms: Lams, npht, Lamb-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Ccdc15
Name: coiled-coil domain containing 15
Synonyms: A630039F14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245902
VEGA: 9
Homologene: 28448
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: chromatin remodeling factor, E430018P19Rik, KMT2H, 8030453L17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
2310011J03Rik
Name: RIKEN cDNA 2310011J03 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66374
Homologene: 11959
Zzz3
Name: zinc finger, ZZ domain containing 3
Synonyms: 3110065C23Rik, 6430567E01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 108946
Homologene: 9182
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: E430013J17Rik, Fam65b, 1700108N18Rik, 6330500D04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 193385
Homologene: 9284
Clec18a
Name: C-type lectin domain family 18, member A
Synonyms: Mrcl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353287
Homologene: 18755
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, b2b414Clo, Dnchc2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, m152Asp, m407Asp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Ctsc
Name: cathepsin C
Synonyms: DPP1, dipeptidylpeptidase 1, DPPI
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13032
HGNC: HGNC:2528
Homologene: 1373
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Pcdh12
Name: protocadherin 12
Synonyms: vascular endothelial cadherin-2, VE-cadherin-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53601
HGNC: HGNC:8657
Homologene: 9574
Txndc12
Name: thioredoxin domain containing 12 (endoplasmic reticulum)
Synonyms: 0610040B21Rik, ERp16
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66073
Homologene: 41074
Ldlrad4
Name: low density lipoprotein receptor class A domain containing 4
Synonyms: D18Ertd653e, A430108L08Rik, D330030L18Rik, 8230401C20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52662
VEGA: 18
HGNC: HGNC:1224
Homologene: 3202
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy3, hyrh, hy-3, 1700034M11Rik, 4930545D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, Fath2, mKIAA0811, LOC245827
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Col11a2
Name: collagen, type XI, alpha 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12815
HGNC: HGNC:2187
Homologene: 22547
Mapre2
Name: microtubule-associated protein, RP/EB family, member 2
Synonyms: D18Abb1e, EB2, RP1, C820009F03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 212307
HGNC: HGNC:6891
Homologene: 134539
Sema6b
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Synonyms: VIb, Sema, semaZ, Seman
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20359
VEGA: 17
Homologene: 8428
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: 4732499L03Rik, melastatin, Mlsn1, LTRPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Macc1
Name: metastasis associated in colon cancer 1
Synonyms: 4732474O15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238455
Homologene: 18813
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Vmn1r48
Name: vomeronasal 1 receptor 48
Synonyms: V1ra3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113845
Homologene: 137651
Ctse
Name: cathepsin E
Synonyms: A430072O03Rik, CE, C920004C08Rik, CatE
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13034
HGNC: HGNC:2530
Homologene: 37551
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: EG244114, Vmn2r72-ps
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244114
Homologene: 115466
Alpk3
Name: alpha-kinase 3
Synonyms: Midori
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 116904
Homologene: 10813
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: 1110001D15Rik, EG235580, Vwa6, Dvwa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Zfp93
Name: zinc finger protein 93
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22755
Homologene: 117959
Pcdhb9
Name: protocadherin beta 9
Synonyms: PcdhbI, Pcdhb4C
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93880
HGNC: HGNC:8689
Homologene: 87124
Rmc1
Name: regulator of MON1-CCZ1
Synonyms: 3110002H16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76482
Homologene: 8341
Gmcl1
Name: germ cell-less, spermatogenesis associated 1
Synonyms: 2810049L19Rik, mglc-1, Btbd13, Gcl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23885
Homologene: 8021
Cyp2c23
Name: cytochrome P450, family 2, subfamily c, polypeptide 23
Synonyms: Cyp2c44
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226143
Homologene: 115563
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: cytoplasmic linker protein 50, restin, Clip 170, Clip50, Rsn, 4631429H07Rik, 1110007I12Rik, CLIP-170
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56430
Homologene: 74455
Saxo4
Name: stabilizer of axonemal microtubules 4
Synonyms: IIIG9, IIIG9L, 4930579J09Rik, Ppp1r32, IIIG9S
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67752
VEGA: 19
Homologene: 15863
Prag1
Name: PEAK1 related kinase activating pseudokinase 1
Synonyms: NACK, D8Ertd82e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244418
Homologene: 18256
Trabd
Name: TraB domain containing
Synonyms: 5730502D15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67976
Homologene: 36427
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
Prl3c1
Name: prolactin family 3, subfamily c, member 1
Synonyms: PLP-J, PLP I, Prlpj
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27372
Homologene: 49353
Adam3
Name: ADAM metallopeptidase domain 3
Synonyms: Taz83, ADAM3, Taz83, tMDC, Cyrn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Naa30
Name: N(alpha)-acetyltransferase 30, NatC catalytic subunit
Synonyms: 5730533P17Rik, Nat12, 4930487N19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70646
Homologene: 17947
Or8d2
Name: olfactory receptor family 8 subfamily D member 2
Synonyms: MOR171-27P, Olfr1520-ps1, Olfr924, MOR171-47, MOR171-27P, GA_x6K02T2PVTD-32543982-32544908
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 404322
VEGA: 9
HGNC: HGNC:8482
Homologene: 128215
Or5ac17
Name: olfactory receptor family 5 subfamily AC member 17
Synonyms: Olfr199, GA_x54KRFPKG5P-55430495-55429569, MOR182-14
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 404310
Homologene: 37011
Castor2
Name: cytosolic arginine sensor for mTORC1 subunit 2
Synonyms: Gats, Gatsl2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80909
Homologene: 84866
Mzf1
Name: myeloid zinc finger 1
Synonyms: Zfp121, Mzf2, Znf42, Zfp98
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109889
Homologene: 9633
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: B230218P12Rik, A330103J02Rik, LOC382816, B330007M19Rik, Chapsyn-110, PSD93, Dlgh2, Gm21505
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Vmn1r175
Name: vomeronasal 1 receptor 175
Synonyms: Gm6299
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 622222
Homologene: 128341
Cd200r4
Name: CD200 receptor 4
Synonyms: F630107N04Rik, MCD200RLa
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239849
Homologene: 45557
Osr2
Name: odd-skipped related 2
Synonyms: Osr2A, 5430409I15Rik, Osr2B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107587
VEGA: 15
Homologene: 14200
Aph1a
Name: aph1 homolog A, gamma secretase subunit
Synonyms: 6530402N02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 226548
Homologene: 9345
Galt
Name: galactose-1-phosphate uridyl transferase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14430
HGNC: HGNC:4135
Homologene: 126
Lrit3
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
Synonyms: LOC242235
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242235
Homologene: 19426
Tle7
Name: TLE family member 7
Synonyms: Gm21964
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102638837
VEGA: 8
Homologene: 131708
Gm7356
Name: predicted gene 7356
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 664821
Homologene: 133217
Igkv4-68
Name: immunoglobulin kappa variable 4-68
Synonyms: LOC232058, LOC384515
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 384515
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 131,672,511 bp
  • C to A, chromosome 1 at 185,398,394 bp
  • T to A, chromosome 3 at 89,063,707 bp
  • T to C, chromosome 3 at 95,894,838 bp
  • T to C, chromosome 3 at 129,800,635 bp
  • A to G, chromosome 3 at 152,449,648 bp
  • A to T, chromosome 4 at 41,757,226 bp
  • G to T, chromosome 4 at 108,853,222 bp
  • A to G, chromosome 5 at 96,554,855 bp
  • A to G, chromosome 5 at 123,630,719 bp
  • T to C, chromosome 5 at 134,137,097 bp
  • A to T, chromosome 6 at 23,002,540 bp
  • A to T, chromosome 6 at 69,305,322 bp
  • G to T, chromosome 6 at 86,721,426 bp
  • A to T, chromosome 6 at 90,036,012 bp
  • T to A, chromosome 7 at 13,044,352 bp
  • T to C, chromosome 7 at 23,809,098 bp
  • T to A, chromosome 7 at 24,276,460 bp
  • T to C, chromosome 7 at 64,199,269 bp
  • A to G, chromosome 7 at 81,093,722 bp
  • G to A, chromosome 7 at 85,751,233 bp
  • A to T, chromosome 7 at 88,302,208 bp
  • G to A, chromosome 7 at 92,386,932 bp
  • A to G, chromosome 8 at 24,707,437 bp
  • G to A, chromosome 8 at 36,147,239 bp
  • A to G, chromosome 8 at 110,108,861 bp
  • A to G, chromosome 8 at 110,452,036 bp
  • A to G, chromosome 8 at 111,072,051 bp
  • A to T, chromosome 9 at 7,001,473 bp
  • C to T, chromosome 9 at 37,315,457 bp
  • T to A, chromosome 9 at 38,848,466 bp
  • A to G, chromosome 9 at 106,067,898 bp
  • C to T, chromosome 9 at 108,480,646 bp
  • T to A, chromosome 10 at 80,319,527 bp
  • T to C, chromosome 11 at 55,252,084 bp
  • T to A, chromosome 12 at 51,791,290 bp
  • A to T, chromosome 12 at 71,952,489 bp
  • A to G, chromosome 12 at 105,662,940 bp
  • C to G, chromosome 12 at 111,985,066 bp
  • A to G, chromosome 12 at 119,445,993 bp
  • A to G, chromosome 13 at 24,695,617 bp
  • T to C, chromosome 13 at 27,199,347 bp
  • T to A, chromosome 14 at 49,173,408 bp
  • A to C, chromosome 14 at 66,108,057 bp
  • T to A, chromosome 14 at 99,196,395 bp
  • T to C, chromosome 15 at 35,301,917 bp
  • T to C, chromosome 15 at 76,059,188 bp
  • T to A, chromosome 15 at 89,085,821 bp
  • T to A, chromosome 16 at 44,833,141 bp
  • A to G, chromosome 16 at 59,215,989 bp
  • T to C, chromosome 17 at 14,001,321 bp
  • G to A, chromosome 17 at 34,061,256 bp
  • G to A, chromosome 17 at 56,128,448 bp
  • T to C, chromosome 18 at 12,188,633 bp
  • T to A, chromosome 18 at 20,580,549 bp
  • T to A, chromosome 18 at 23,858,161 bp
  • T to G, chromosome 18 at 37,303,239 bp
  • T to A, chromosome 18 at 37,403,155 bp
  • A to T, chromosome 18 at 38,282,797 bp
  • C to T, chromosome 18 at 68,254,222 bp
  • A to G, chromosome 18 at 76,137,327 bp
  • A to T, chromosome 19 at 10,478,265 bp
  • T to C, chromosome 19 at 44,021,627 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8157 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067583-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.