Strain Name:
C57BL/6J-MtgxR8176Btlr/Mmmh
Stock Number:
067601-MU
Citation ID:
RRID:MMRRC_067601-MU
Other Names:
R8176 (G1)
Major Collection:

Strain Information

Marchf4
Name: membrane associated ring-CH-type finger 4
Synonyms: March4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381270
Homologene: 66199
Ly6a
Name: lymphocyte antigen 6 family member A
Synonyms: Sca1, Ly-6A.2, Ly-6E.1, Sca-1, Ly-6A/E, TAP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110454
Homologene: 113718
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, ne, b2b1562Clo, 6030440P17Rik, my
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Mta1
Name: metastasis associated 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 116870
HGNC: HGNC:7410
Homologene: 3442
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Sh3p17, EHSH1, Intersectin-L, Ese1, Eh domain, SH3 domain regulator of endocytosis 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Skap2
Name: src family associated phosphoprotein 2
Synonyms: Saps, 2610021A10Rik, SKAP-HOM, RA70, mSKAP55R
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54353
Homologene: 2919
Fam117a
Name: family with sequence similarity 117, member A
Synonyms: 5730593F17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215512
Homologene: 12775
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: Sra-1, l(7)1Rl, P140SRA-1, E030028J09Rik, Shyc, pl-1, l7Rl1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20430
Homologene: 22628
Tm9sf2
Name: transmembrane 9 superfamily member 2
Synonyms: P76, D14Ertd64e, 1500001N15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68059
Homologene: 21004
Hsf2
Name: heat shock factor 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15500
VEGA: 10
HGNC: HGNC:5225
Homologene: 37931
Bms1
Name: BMS1, ribosome biogenesis factor
Synonyms: Bms1l
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213895
Homologene: 7065
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: Psa, MP100
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Adam8
Name: a disintegrin and metallopeptidase domain 8
Synonyms: CD156a, MS2, CD156, E430039A18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11501
HGNC: HGNC:215
Homologene: 74384
Bcl2
Name: B cell leukemia/lymphoma 2
Synonyms: C430015F12Rik, Bcl-2, D830018M01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12043
HGNC: HGNC:990
Homologene: 527
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 404710
Homologene: 26400
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, Olfaxin, A230083H22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Cd300lg
Name: CD300 molecule like family member G
Synonyms: Clm9, 2310016B05Rik, D11Ertd736e, nepmucin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52685
Homologene: 17059
Cdc34
Name: cell division cycle 34
Synonyms: UBE2R1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216150
VEGA: 10
HGNC: HGNC:1734
Homologene: 55815
Cenpe
Name: centromere protein E
Synonyms: Kif10, 312kDa, CENP-E, N-7 kinesin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Alg12
Name: ALG12 alpha-1,6-mannosyltransferase
Synonyms: ECM39, mannosyltransferase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223774
Homologene: 36269
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Rbp-3, Irbp
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Dach1
Name: dachshund family transcription factor 1
Synonyms: Dac, E130112M23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Ncoa1
Name: nuclear receptor coactivator 1
Synonyms: KAT13A, bHLHe74, SRC-1, SRC-a/NCoA-1, steroid receptor coactivator-1, SRC1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17977
VEGA: 12
HGNC: HGNC:7668
Homologene: 7859
Stat5a
Name: signal transducer and activator of transcription 5A
Synonyms: STAT5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20850
Homologene: 20680
C1rl
Name: complement component 1, r subcomponent-like
Synonyms: C1rl1, C1r-LP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232371
Homologene: 9559
Ppil3
Name: peptidylprolyl isomerase (cyclophilin)-like 3
Synonyms: Cyp10l, 2510026K04Rik, 2310076N22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70225
HGNC: HGNC:9262
Homologene: 41717
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, Gm980, A230079K17Rik, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70885
Homologene: 10029
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668940
Homologene: 66117
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Fgd5
Name: FYVE, RhoGEF and PH domain containing 5
Synonyms: ZFYVE23, C330025N11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232237
Homologene: 27798
Eeig1
Name: estrogen-induced osteoclastogenesis regulator 1
Synonyms: Fam102a, C230093N12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98952
Homologene: 51943
Gtf3c5
Name: general transcription factor IIIC, polypeptide 5
Synonyms: TFiiiC2-63, TFIIIC63, 2700084A09Rik, TFIIICepsilon
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70239
HGNC: HGNC:4668
Homologene: 40806
Abca6
Name: ATP-binding cassette, sub-family A member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171382
Homologene: 23433
Aatk
Name: apoptosis-associated tyrosine kinase
Synonyms: AATYK1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11302
HGNC: HGNC:21
Homologene: 74861
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338349
Homologene: 9805
Onecut2
Name: one cut domain, family member 2
Synonyms: OC-2, Oc2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225631
HGNC: HGNC:8139
Homologene: 113592
Sec16b
Name: SEC16 homolog B, endoplasmic reticulum export factor
Synonyms: Lztr2, Rgpr, Rgpr-p117
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 89867
Homologene: 13227
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4632415N18Rik, D19Ertd652e, 4930428C11Rik, Wdr96, 4930463G05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100048534
Homologene: 36425
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: ELK1, Kv12.1, C130090D05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 211468
Homologene: 14332
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Foxi3
Name: forkhead box I3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232077
Homologene: 52949
6030469F06Rik
Name: RIKEN cDNA 6030469F06 gene
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100043065
VEGA: 12
Pdp2
Name: pyruvate dehydrogenase phosphatase catalytic subunit 2
Synonyms: LOC382051, 4833426J09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382051
Homologene: 36388
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: NEDL1, E130207I19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Efhb
Name: EF hand domain family, member B
Synonyms: 4921525D22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 211482
VEGA: 17
Homologene: 16982
Rhot2
Name: ras homolog family member T2
Synonyms: Arht2, Miro2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214952
Homologene: 56038
Dusp13b
Name: dual specificity phosphatase 13B
Synonyms: LOC382853, Dusp13, TS-DSP6, LMW-DSP6, TMDP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27389
Homologene: 121602
Or10j27
Name: olfactory receptor family 10 subfamily J member 27
Synonyms: GA_x6K02T2R7CC-715776-716708, MOR267-4, Olfr1408
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258759
Homologene: 128062
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: AIDA-1b, LOC380650, E530015N03Rik, Gm10937, C030032C09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77531
Homologene: 51570
Btd
Name: biotinidase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 26363
HGNC: HGNC:1122
Homologene: 37255
Or52e19b
Name: olfactory receptor family 52 subfamily E member 19B
Synonyms: MOR32-2, Olfr603, MOR32-14_i, GA_x6K02T2PBJ9-6092550-6092362, Olfr604, GA_x6K02T2PBJ9-6096387-6095449
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259073
Homologene: 121535
Or6c5
Name: olfactory receptor family 6 subfamily C member 5
Synonyms: Olfr774, GA_x6K02T2PULF-10924432-10925370, MOR111-2, MOR111-11
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258232
Homologene: 105326
Pex11b
Name: peroxisomal biogenesis factor 11 beta
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18632
HGNC: HGNC:8853
Homologene: 2852
Spata31d1b
Name: spermatogenesis associated 31 subfamily D, member 1B
Synonyms: Gm4934, Fam75d1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238662
VEGA: 13
Gm21915
Name: predicted gene, 21915
Type: Gene
Species: Mouse
Chromosome: 9
Sgol2a
Name:
Type: Gene
Species: Mouse
Chromosome: 1
Potefam2
Name: POTE ankyrin domain family member 2
Synonyms: Tssk1b, Pote2, A26c2, EG622251
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 622251
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,017,093 bp
  • A to T, chromosome 1 at 58,440,919 bp
  • T to C, chromosome 1 at 72,534,839 bp
  • A to T, chromosome 1 at 88,365,115 bp
  • T to C, chromosome 1 at 106,712,798 bp
  • C to A, chromosome 1 at 157,535,411 bp
  • C to T, chromosome 1 at 173,130,816 bp
  • C to T, chromosome 1 at 181,657,033 bp
  • A to G, chromosome 2 at 28,570,417 bp
  • A to G, chromosome 2 at 32,563,612 bp
  • A to G, chromosome 2 at 155,625,966 bp
  • A to T, chromosome 3 at 53,655,340 bp
  • A to G, chromosome 3 at 88,094,650 bp
  • G to T, chromosome 3 at 96,643,711 bp
  • A to G, chromosome 3 at 135,230,090 bp
  • C to T, chromosome 4 at 84,888,689 bp
  • T to C, chromosome 6 at 51,907,898 bp
  • T to A, chromosome 6 at 70,957,033 bp
  • T to A, chromosome 6 at 91,987,984 bp
  • G to T, chromosome 6 at 118,418,450 bp
  • T to C, chromosome 6 at 124,493,885 bp
  • T to C, chromosome 7 at 28,091,749 bp
  • A to T, chromosome 7 at 55,924,427 bp
  • T to C, chromosome 7 at 62,783,035 bp
  • G to A, chromosome 7 at 103,383,864 bp
  • T to C, chromosome 7 at 139,988,873 bp
  • T to A, chromosome 8 at 68,802,951 bp
  • A to G, chromosome 8 at 104,595,055 bp
  • T to A, chromosome 9 at 40,670,970 bp
  • C to T, chromosome 9 at 42,359,169 bp
  • T to A, chromosome 10 at 57,505,194 bp
  • T to C, chromosome 10 at 79,682,528 bp
  • C to A, chromosome 10 at 90,069,491 bp
  • T to G, chromosome 10 at 129,238,878 bp
  • A to G, chromosome 11 at 60,706,561 bp
  • G to T, chromosome 11 at 95,337,139 bp
  • A to G, chromosome 11 at 97,236,151 bp
  • T to A, chromosome 11 at 100,876,863 bp
  • A to T, chromosome 11 at 102,041,564 bp
  • A to C, chromosome 11 at 110,244,194 bp
  • A to G, chromosome 11 at 120,016,415 bp
  • A to G, chromosome 12 at 4,267,858 bp
  • T to A, chromosome 12 at 31,185,136 bp
  • A to G, chromosome 12 at 113,120,836 bp
  • A to T, chromosome 13 at 14,247,701 bp
  • T to C, chromosome 13 at 38,192,810 bp
  • A to G, chromosome 13 at 59,717,303 bp
  • T to C, chromosome 14 at 21,747,481 bp
  • C to A, chromosome 14 at 31,347,772 bp
  • T to A, chromosome 14 at 31,662,116 bp
  • C to A, chromosome 14 at 33,955,648 bp
  • C to T, chromosome 14 at 97,916,480 bp
  • T to G, chromosome 14 at 122,137,501 bp
  • C to T, chromosome 15 at 74,996,451 bp
  • A to G, chromosome 15 at 88,805,881 bp
  • T to A, chromosome 16 at 91,848,709 bp
  • T to C, chromosome 17 at 25,844,094 bp
  • T to C, chromosome 17 at 52,978,094 bp
  • T to C, chromosome 17 at 53,400,846 bp
  • A to T, chromosome 18 at 64,340,860 bp
  • T to C, chromosome 19 at 17,118,292 bp
  • T to C, chromosome 19 at 47,795,675 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8176 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067601-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.