Strain Name:
C57BL/6J-MtgxR8371Btlr/Mmmh
Stock Number:
067740-MU
Citation ID:
RRID:MMRRC_067740-MU
Other Names:
R8371 (G1)
Major Collection:

Strain Information

B4galt5
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
Synonyms: 9430078I07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56336
HGNC: HGNC:928
Homologene: 3507
Dhrs3
Name: dehydrogenase/reductase 3
Synonyms: retSDR1, Rsdr1, dehydrogenase/reductase (SDR family) member 3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20148
Homologene: 20994
Cd40
Name: CD40 antigen
Synonyms: p50, Tnfrsf5, Bp50, Cd40
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21939
Homologene: 954
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Gpr55
Name: G protein-coupled receptor 55
Synonyms: LOC227326, CTFL
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227326
HGNC: HGNC:4511
Homologene: 36184
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: 1500002J22Rik, eIF4GII, G1-419-52, repro8, 4930523M17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Fmn2
Name: formin 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54418
Homologene: 137334
Dhx9
Name: DExH-box helicase 9
Synonyms: leukophysin, Ddx9, RHA, NDHII, NDH II, nuclear DNA helicase II, RNA helicase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Srrm1
Name: serine/arginine repetitive matrix 1
Synonyms: SRm160
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 51796
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Tbck
Name: TBC1 domain containing kinase
Synonyms: A630047E20Rik, C030007I09Rik, 1700120J03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 271981
Homologene: 13221
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: 5830451P18Rik, Duplin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67772
Homologene: 72405
Rrp1b
Name: ribosomal RNA processing 1B
Synonyms: 2600005C20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72462
Homologene: 57086
Stt3b
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
Synonyms: Simp, 1300006C19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68292
VEGA: 9
Homologene: 7387
Rhot1
Name: ras homolog family member T1
Synonyms: Arht1, Miro1, FLJ11040, 2210403N23Rik, C430039G08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 59040
Homologene: 56803
Trim71
Name: tripartite motif-containing 71
Synonyms: 2610206G21Rik, LOC382112, 636931, mlin-41, lin-41, mLin41, Lin41
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 636931
Homologene: 9076
Lmo7
Name: LIM domain only 7
Synonyms: FBXO20, LOC380928
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Hgfac
Name: hepatocyte growth factor activator
Synonyms: HGFA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54426
HGNC: HGNC:4894
Homologene: 1170
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216766
Homologene: 9155
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239102
Homologene: 52657
Lemd1
Name: LEM domain containing 1
Synonyms: 4930540I23Rik, LEMP-1, 6430514M23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213409
Dhx57
Name: DExH-box helicase 57
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Tnfsf9
Name: tumor necrosis factor (ligand) superfamily, member 9
Synonyms: 4-1BB-L, 4-1BB ligand, 4-1BBL, Ly63l, Cd137l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21950
VEGA: 17
Homologene: 137221
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80797
HGNC: HGNC:2017
Homologene: 77224
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 629499
Homologene: 51864
Zc3h12d
Name: zinc finger CCCH type containing 12D
Synonyms: TFL, D730019B10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237256
VEGA: 10
Homologene: 18225
Ephx4
Name: epoxide hydrolase 4
Synonyms: Abhd7, LOC384214
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384214
Homologene: 62402
Abca8a
Name: ATP-binding cassette, sub-family A member 8a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, alpha(1B), Cav2.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
Synonyms: Scnn1, ENaC alpha, mENaC
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20276
Homologene: 811
Jade2
Name: jade family PHD finger 2
Synonyms: Phf15, 1200017K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76901
Homologene: 9082
Ccdc178
Name: coiled coil domain containing 178
Synonyms: 4921528I01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70950
VEGA: 18
Homologene: 12373
Cbr1
Name: carbonyl reductase 1
Synonyms: CR
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12408
HGNC: HGNC:1548
Homologene: 37524
Or2n1c
Name: olfactory receptor family 2 subfamily N member 1C
Synonyms: GA_x6K02T2PSCP-2656648-2657586, Olfr135, MOR256-48
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258329
Homologene: 110603
Krt82
Name: keratin 82
Synonyms: Krt2-20
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 114566
VEGA: 15
HGNC: HGNC:6459
Homologene: 13200
Klhl33
Name: kelch-like 33
Synonyms: EG546611
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 546611
VEGA: 14
Homologene: 52385
Xirp1
Name: xin actin-binding repeat containing 1
Synonyms: Cmya1, Xin, mXin alpha
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22437
VEGA: 9
Homologene: 7998
Cyp3a11
Name: cytochrome P450, family 3, subfamily a, polypeptide 11
Synonyms: Pcn, Cyp3a, IIIAm1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13112
HGNC: HGNC:2638
Homologene: 133568
Serpinb12
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12
Synonyms: 4833409F13Rik, 2300003F07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71869
Homologene: 23631
Tspoap1
Name: TSPO associated protein 1
Synonyms: Bzrap1, peripheral
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207777
Homologene: 37961
Fhl4
Name: four and a half LIM domains 4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14202
VEGA: 10
Slc26a3
Name: solute carrier family 26, member 3
Synonyms: Dra, 9130013M11Rik, 9030623B18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13487
HGNC: HGNC:3018
Homologene: 55435
Zfy2
Name: zinc finger protein 2, Y-linked
Synonyms: Zfy-2
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 22768
Homologene: 56456
Lrp8
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms: 4932703M08Rik, apoER2, Lr8b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16975
HGNC: HGNC:6700
Homologene: 31250
Redic1
Name: regulator of DNA class I crossover intermediates 1
Synonyms: CN725425, Gm5807
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545126
Birc3
Name: baculoviral IAP repeat-containing 3
Synonyms: cIAP2, Api2, cIAP-2, IAP2, RNF49, HIAP2, MIAP2, MIHC
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11796
HGNC: HGNC:591
Homologene: 899
Or51a25
Name: olfactory receptor family 51 subfamily A member 25
Synonyms: GA_x6K02T2PBJ9-5441154-5440198, MOR11-1, Olfr559
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259116
Homologene: 74124
Serpinb3d
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394252
Homologene: 130559
Miga2
Name: mitoguardin 2
Synonyms: Fam73b, 5730472N09Rik, R74766
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108958
Homologene: 13125
Dmgdh
Name: dimethylglycine dehydrogenase precursor
Synonyms: 1200014D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74129
Homologene: 8372
Kcnq5
Name: potassium voltage-gated channel, subfamily Q, member 5
Synonyms: 9230107O05Rik, D1Mgi1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226922
HGNC: HGNC:6299
Homologene: 28270
Rhd
Name: Rh blood group, D antigen
Synonyms: Rhced, Rhl1, Rh
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19746
Homologene: 7918
Cers1
Name: ceramide synthase 1
Synonyms: to, Uog-1, CerS1, Lass1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93898
Homologene: 128762
Csf1r
Name: colony stimulating factor 1 receptor
Synonyms: Fim-2, CSF-1R, M-CSFR, Csfmr, CD115, Fms, Fim2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12978
HGNC: HGNC:2433
Homologene: 3817
Kcnj4
Name: potassium inwardly-rectifying channel, subfamily J, member 4
Synonyms: MB-IRK3, IRK3, Kcnf2, Kir 2.3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16520
VEGA: 15
HGNC: HGNC:6265
Homologene: 3653
Clec4a1
Name: C-type lectin domain family 4, member a1
Synonyms: mDcir4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269799
Homologene: 72399
Taf7
Name: TATA-box binding protein associated factor 7
Synonyms: Taf2f, TAFII55, 55kDa
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 24074
Homologene: 133942
Pcdha6
Name: protocadherin alpha 6
Synonyms: Cnr2, Crnr2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12937
Homologene: 75098
Or5p61
Name: olfactory receptor family 5 subfamily P member 61
Synonyms: MOR204-30P, GA_x6K02T2PBJ9-10489044-10488091, Olfr485, MOR204-40_p
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258041
Homologene: 110483
Pcdha2
Name: protocadherin alpha 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353234
HGNC: HGNC:8668
Homologene: 135719
Cys1
Name: cystin 1
Synonyms: ck, 2900006B19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12879
Homologene: 84604
Gm9195
Name: predicted gene 9195
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 675947
Homologene: 139067
Eppk1
Name: epiplakin 1
Synonyms: EPIPL1, EPPK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223650
VEGA: 15
Homologene: 20006
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 21,479,424 bp
  • A to T, chromosome 1 at 85,941,127 bp
  • A to T, chromosome 1 at 106,956,405 bp
  • T to C, chromosome 1 at 107,080,739 bp
  • C to A, chromosome 1 at 132,228,949 bp
  • T to C, chromosome 1 at 153,456,215 bp
  • T to C, chromosome 1 at 174,609,607 bp
  • T to C, chromosome 2 at 24,720,024 bp
  • AAGAG to AAG, chromosome 2 at 30,375,743 bp
  • A to T, chromosome 2 at 157,252,976 bp
  • G to A, chromosome 2 at 165,066,538 bp
  • A to G, chromosome 2 at 167,309,225 bp
  • C to A, chromosome 3 at 132,752,524 bp
  • G to T, chromosome 3 at 144,807,353 bp
  • A to G, chromosome 4 at 107,869,071 bp
  • A to G, chromosome 4 at 134,876,383 bp
  • A to T, chromosome 4 at 135,325,221 bp
  • T to G, chromosome 4 at 138,096,845 bp
  • A to C, chromosome 4 at 144,919,383 bp
  • T to A, chromosome 5 at 35,045,443 bp
  • A to T, chromosome 5 at 107,413,518 bp
  • A to T, chromosome 5 at 145,868,628 bp
  • T to A, chromosome 6 at 122,933,923 bp
  • T to G, chromosome 6 at 125,343,843 bp
  • G to A, chromosome 6 at 139,936,056 bp
  • C to A, chromosome 7 at 102,723,583 bp
  • G to A, chromosome 7 at 108,159,228 bp
  • T to A, chromosome 8 at 70,329,573 bp
  • A to G, chromosome 9 at 7,849,426 bp
  • C to A, chromosome 9 at 114,515,789 bp
  • A to G, chromosome 9 at 115,266,175 bp
  • C to T, chromosome 9 at 120,019,433 bp
  • GCCC to GCC, chromosome 10 at 7,839,971 bp
  • G to A, chromosome 10 at 85,098,773 bp
  • T to A, chromosome 11 at 51,825,132 bp
  • T to C, chromosome 11 at 58,126,558 bp
  • T to C, chromosome 11 at 80,243,466 bp
  • T to G, chromosome 11 at 87,778,301 bp
  • G to T, chromosome 11 at 110,054,647 bp
  • A to G, chromosome 12 at 24,668,695 bp
  • A to T, chromosome 12 at 31,452,542 bp
  • T to A, chromosome 13 at 93,708,730 bp
  • C to T, chromosome 14 at 50,892,232 bp
  • T to C, chromosome 14 at 52,232,818 bp
  • T to C, chromosome 14 at 55,064,092 bp
  • C to T, chromosome 14 at 72,460,459 bp
  • T to C, chromosome 14 at 101,887,008 bp
  • C to T, chromosome 15 at 76,110,119 bp
  • T to A, chromosome 15 at 79,485,141 bp
  • T to C, chromosome 15 at 91,240,770 bp
  • T to C, chromosome 15 at 101,545,111 bp
  • A to G, chromosome 16 at 59,557,051 bp
  • A to G, chromosome 16 at 93,609,891 bp
  • A to G, chromosome 17 at 32,049,484 bp
  • G to A, chromosome 17 at 38,208,298 bp
  • A to C, chromosome 17 at 57,105,541 bp
  • T to C, chromosome 17 at 80,275,490 bp
  • T to C, chromosome 18 at 21,811,504 bp
  • T to C, chromosome 18 at 36,940,263 bp
  • T to A, chromosome 18 at 36,969,867 bp
  • T to A, chromosome 18 at 37,643,499 bp
  • T to A, chromosome 18 at 49,898,714 bp
  • A to T, chromosome 18 at 61,117,591 bp
  • T to C, chromosome Y at 2,117,168 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8371 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067740-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.