Strain Name:
C57BL/6J-MtgxR8482Btlr/Mmmh
Stock Number:
067926-MU
Citation ID:
RRID:MMRRC_067926-MU
Other Names:
R8482 (G1)
Major Collection:

Strain Information

Ldb1
Name: LIM domain binding 1
Synonyms: CLIM2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16825
HGNC: HGNC:6532
Homologene: 2891
Rpl38
Name: ribosomal protein L38
Synonyms: Rbt, 0610025G13Rik, Ts, Tss
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67671
Homologene: 87098
Zfhx3
Name: zinc finger homeobox 3
Synonyms: A230102L03Rik, Atbf1, Sci, WBP9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: Elys, 6230412P20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226747
Homologene: 9142
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Hmgxb4
Name: HMG box domain containing 4
Synonyms: Hmgb2l1, 4733401K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70823
HGNC: HGNC:5003
Homologene: 4007
Ets2
Name: E26 avian leukemia oncogene 2, 3' domain
Synonyms: Ets-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 23872
HGNC: HGNC:3489
Homologene: 3838
Pex1
Name: peroxisomal biogenesis factor 1
Synonyms: 5430414H02Rik, ZWS1, E330005K07Rik, peroxisome biogenesis factor 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71382
HGNC: HGNC:8850
Homologene: 27006
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231214
Homologene: 18159
Lpcat1
Name: lysophosphatidylcholine acyltransferase 1
Synonyms: LPCAT, rd11, Aytl2, 2900035H07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210992
Homologene: 9871
Neurl1a
Name: neuralized E3 ubiquitin protein ligase 1A
Synonyms: Rnf67, Neur1, Neurl, 2410129E16Rik, Neu1, Nlz
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18011
VEGA: 19
HGNC: HGNC:7761
Homologene: 32503
Hdc
Name: histidine decarboxylase
Synonyms: Hdc-c, L-histidine decarboxylase, Hdc-s, Hdc-e, Hdc-a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15186
HGNC: HGNC:4855
Homologene: 20490
Lrfn4
Name: leucine rich repeat and fibronectin type III domain containing 4
Synonyms: SALM3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225875
Homologene: 36415
Selenot
Name: selenoprotein T
Synonyms: 2810407C02Rik, SelT, Selt, 5730408P04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69227
Homologene: 32304
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Clec4a2
Name: C-type lectin domain family 4, member a2
Synonyms: Dcir1, Clecsf6, DCIR, dendritic cell immunoreceptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26888
Homologene: 49291
Zfp998
Name: zinc finger protein 998
Synonyms: Gt(Ayu21)35Imeg, Gt(pU21)35Imeg, Snerv1, 2410141K09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76803
Homologene: 136362
Pkd2l2
Name: polycystic kidney disease 2-like 2
Synonyms: TRPP5, Polycystin - L2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53871
VEGA: 18
HGNC: HGNC:9012
Homologene: 22812
Col13a1
Name: collagen, type XIII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12817
HGNC: HGNC:2190
Homologene: 22421
Rac2
Name: Rac family small GTPase 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19354
VEGA: 15
HGNC: HGNC:9802
Homologene: 55699
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Nyap2
Name: neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
Synonyms: 9430031J16Rik, Jr6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241134
Homologene: 18239
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Nudt8
Name: nudix hydrolase 8
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 8, 2310039H17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66387
VEGA: 19
HGNC: HGNC:8055
Homologene: 41633
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195046
Homologene: 133820
Zfp652
Name: zinc finger protein 652
Synonyms: 9530033F24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268469
Homologene: 54768
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 245860
Homologene: 34495
Ccdc97
Name: coiled-coil domain containing 97
Synonyms: 1200014H14Rik, 2810446P04Rik, D7Ertd462e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52132
Homologene: 32701
Pnpla8
Name: patatin-like phospholipase domain containing 8
Synonyms: iPLA2 gamma, 1200006O19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67452
Homologene: 12136
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Myo15b
Name: myosin XVB
Synonyms: LOC380737, E330039G21Rik, LOC217328
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Slc19a1
Name: solute carrier family 19 (folate transporter), member 1
Synonyms: reduced folate carrier, RFC-1, RFC1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20509
Homologene: 57139
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228846
Homologene: 18598
Atxn1
Name: ataxin 1
Synonyms: 2900016G23Rik, Sca1, Atx1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20238
VEGA: 13
Homologene: 281
Nfasc
Name: neurofascin
Synonyms: D430023G06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269116
Homologene: 24945
Osbpl5
Name: oxysterol binding protein-like 5
Synonyms: ORP5, Obph1, 1110006M06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 79196
Homologene: 98024
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74376
Homologene: 53435
Acan
Name: aggrecan
Synonyms: b2b183Clo, Agc1, Cspg1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11595
HGNC: HGNC:319
Homologene: 137204
Entrep1
Name: endosomal transmembrane epsin interactor 1
Synonyms: LOC381217, Fam189a2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381217
VEGA: 19
Homologene: 3540
Ngly1
Name: N-glycanase 1
Synonyms: 1110002C09Rik, PNGase, Png1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 59007
Homologene: 10117
Pfkm
Name: phosphofructokinase, muscle
Synonyms: Pfkx, PFK-A, Pfk4, PFK-M, Pfk-4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18642
VEGA: 15
HGNC: HGNC:8877
Homologene: 20101
Or10ag56
Name: olfactory receptor family 10 subfamily AG member 56
Synonyms: Olfr1118-ps, Olfr1118, GA_x6K02T2Q125-48795705-48796673, MOR264-22
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404328
Homologene: 134077
Sgcg
Name: sarcoglycan, gamma (dystrophin-associated glycoprotein)
Synonyms: 5430420E18Rik, gamma-SG
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 24053
Homologene: 194
Fhit
Name: fragile histidine triad gene
Synonyms: Fra14A2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14198
HGNC: HGNC:3701
Homologene: 21661
Adprh
Name: ADP-ribosylarginine hydrolase
Synonyms: Arh1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11544
VEGA: 16
HGNC: HGNC:269
Homologene: 874
Qdpr
Name: quinoid dihydropteridine reductase
Synonyms: 2610008L04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 110391
HGNC: HGNC:9752
Homologene: 271
Rnaset2b
Name: ribonuclease T2B
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68195
VEGA: 17
Homologene: 31190
Npw
Name: neuropeptide W
Synonyms: LOC381073
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381073
Homologene: 17727
Prxl2a
Name: peroxiredoxin like 2A
Synonyms: 5730469M10Rik, Adrx, Fam213a, Adiporedoxin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70564
Homologene: 12356
Gm6685
Name: predicted pseudogene 6685
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 626571
VEGA: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 75,186,226 bp
  • A to T, chromosome 1 at 81,241,637 bp
  • T to C, chromosome 1 at 132,605,089 bp
  • A to G, chromosome 1 at 150,433,700 bp
  • A to G, chromosome 1 at 179,763,542 bp
  • G to A, chromosome 2 at 87,309,382 bp
  • G to A, chromosome 2 at 126,594,205 bp
  • G to T, chromosome 2 at 158,216,932 bp
  • T to C, chromosome 3 at 58,588,468 bp
  • C to T, chromosome 4 at 152,356,690 bp
  • A to T, chromosome 5 at 3,612,923 bp
  • A to T, chromosome 5 at 43,695,239 bp
  • G to T, chromosome 5 at 45,439,346 bp
  • C to A, chromosome 5 at 112,871,623 bp
  • T to C, chromosome 6 at 123,123,671 bp
  • T to C, chromosome 7 at 25,715,002 bp
  • G to A, chromosome 7 at 79,096,744 bp
  • T to A, chromosome 7 at 143,704,994 bp
  • G to A, chromosome 8 at 75,029,594 bp
  • A to G, chromosome 8 at 108,947,879 bp
  • T to C, chromosome 9 at 16,246,967 bp
  • A to G, chromosome 10 at 61,884,698 bp
  • A to G, chromosome 10 at 77,049,663 bp
  • T to C, chromosome 11 at 28,339,195 bp
  • A to T, chromosome 11 at 71,109,075 bp
  • T to C, chromosome 11 at 95,752,893 bp
  • T to C, chromosome 11 at 107,043,698 bp
  • T to A, chromosome 11 at 114,672,288 bp
  • C to T, chromosome 11 at 115,883,257 bp
  • T to A, chromosome 12 at 25,040,528 bp
  • T to C, chromosome 12 at 44,283,627 bp
  • C to A, chromosome 12 at 98,876,301 bp
  • A to T, chromosome 13 at 45,567,950 bp
  • C to T, chromosome 13 at 66,431,738 bp
  • G to A, chromosome 13 at 73,510,925 bp
  • A to G, chromosome 14 at 10,751,616 bp
  • T to C, chromosome 14 at 16,310,377 bp
  • C to T, chromosome 14 at 40,997,766 bp
  • G to T, chromosome 14 at 61,202,955 bp
  • G to A, chromosome 14 at 61,240,407 bp
  • T to C, chromosome 15 at 78,566,006 bp
  • A to G, chromosome 15 at 98,131,983 bp
  • A to T, chromosome 16 at 38,447,509 bp
  • A to T, chromosome 16 at 95,714,975 bp
  • G to A, chromosome 17 at 6,996,509 bp
  • A to G, chromosome 17 at 24,657,422 bp
  • A to G, chromosome 18 at 34,425,113 bp
  • T to C, chromosome 19 at 4,000,849 bp
  • T to C, chromosome 19 at 4,614,305 bp
  • T to A, chromosome 19 at 23,988,502 bp
  • C to A, chromosome 19 at 46,036,270 bp
  • T to C, chromosome 19 at 47,253,280 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8482 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067926-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.