Strain Name:
C57BL/6J-MtgxR8709Btlr/Mmmh
Stock Number:
068563-MU
Citation ID:
RRID:MMRRC_068563-MU
Other Names:
R8709 (G1)
Major Collection:

Strain Information

Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Sp4
Name: trans-acting transcription factor 4
Synonyms: HF1-b, 5730497N03Rik, HF-1b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20688
VEGA: 12
Homologene: 2341
Cwf19l2
Name: CWF19 like cell cycle control factor 2
Synonyms: 3230401L03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244672
Homologene: 12366
Sephs1
Name: selenophosphate synthetase 1
Synonyms: SPS1, 1110046B24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109079
Homologene: 56558
Cox4i1
Name: cytochrome c oxidase subunit 4I1
Synonyms: Cox4a, Cox4, COXIV
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12857
HGNC: HGNC:2265
Homologene: 37537
Tcf12
Name: transcription factor 12
Synonyms: ME1, REB, bHLHb20, HTF4, HEBAlt, ALF1, HEB, HTF-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21406
Homologene: 40774
Eif4b
Name: eukaryotic translation initiation factor 4B
Synonyms: 2310046H11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75705
VEGA: 15
HGNC: HGNC:3285
Homologene: 83162
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11736
Homologene: 9491
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Cast
Name: calpastatin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12380
VEGA: 13
HGNC: HGNC:1515
Homologene: 7658
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: 3010014K16Rik, 194kDa, mRPA1, Rpo1-4, 2900087K15Rik, RPA194
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20019
Homologene: 7033
Zfp292
Name: zinc finger protein 292
Synonyms: Zfp-15, 5730450D02Rik, Zn-16, Zn-15, 9430062L07Rik, Zfp15, Krox-10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30046
Homologene: 8493
Stag1
Name: STAG1 cohesin complex component
Synonyms: SA-1, Scc3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20842
Homologene: 21191
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: 6720464I07Rik, Solo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7a, LOC381341, Dnahc7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Spag5
Name: sperm associated antigen 5
Synonyms: Astrin, s17, S17, Mastrin, Deepest, MAP126, D11Bhm180e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54141
Homologene: 4718
Spag9
Name: sperm associated antigen 9
Synonyms: 3110018C07Rik, 4733401I23Rik, 4831406C20Rik, syd1, JLP, JIP4, Mapk8ip4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70834
Homologene: 2954
Hspd1
Name: heat shock protein 1 (chaperonin)
Synonyms: Hsp60
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15510
HGNC: HGNC:5261
Homologene: 1626
Itgb1
Name: integrin beta 1 (fibronectin receptor beta)
Synonyms: Fnrb, Gm9863, CD29, beta1 integrin, 4633401G24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16412
HGNC: HGNC:6153
Homologene: 22999
Tomm40
Name: translocase of outer mitochondrial membrane 40
Synonyms: Tom40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53333
Homologene: 101105
Pak4
Name: p21 (RAC1) activated kinase 4
Synonyms: 5730488L07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70584
Homologene: 4300
Nup54
Name: nucleoporin 54
Synonyms: 3110079L04Rik, 54kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269113
Homologene: 41169
Cwc22
Name: CWC22 spliceosome-associated protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80744
Homologene: 6048
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171395
Homologene: 51376
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Lcp2
Name: lymphocyte cytosolic protein 2
Synonyms: m1Khoe, twm, SLP76, SLP-76
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16822
HGNC: HGNC:6529
Homologene: 4065
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Stxbp2
Name: syntaxin binding protein 2
Synonyms: Munc-18b, Sxtp2, Munc-18-2, Munc18b, C79054, muSec1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20911
Homologene: 55530
Adamtsl3
Name: ADAMTS-like 3
Synonyms: 9230119C12Rik, punctin-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: HL19, Hdhc3, Dnahc12, HL-19, LOC380889, DHC3, Dnahc7l, 4921531P07Rik, DLP12
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, D86 mRNA, PKHDL1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 9630046L06Rik, 9430004C13Rik, 1110061O17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Or1p1
Name: olfactory receptor family 1 subfamily P member 1
Synonyms: GA_x6K02T2P1NL-4434429-4435400, Olfr59, IH3, MOR133-3P
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18359
HGNC: HGNC:8222
Homologene: 73924
Adamts9
Name: ADAM metallopeptidase with thrombospondin type 1 motif 9
Synonyms: Mhdaund4, UND4, E030027K14Rik, UND3, 1810011L16Rik, 8430403M15Rik, Gsfund3, Mhdaund3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101401
Homologene: 18821
Cdh17
Name: cadherin 17
Synonyms: BILL-cadherin, HPT-1, LI-cadherin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12557
HGNC: HGNC:1756
Homologene: 56859
Stkld1
Name: serine/threonine kinase-like domain containing 1
Synonyms: LOC279029, Gm711
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 279029
Homologene: 19586
Pxdn
Name: peroxidasin
Synonyms: VPO1, 2310075M15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69675
Homologene: 33907
Gpr22
Name: G protein-coupled receptor 22
Synonyms: 2900068K05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73010
HGNC: HGNC:4477
Homologene: 18420
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Aadacl4fm2
Name: AADACL4 family member 2
Synonyms: Gm13124
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 627085
Homologene: 135767
3100002H09Rik
Name: RIKEN cDNA 3100002H09 gene
Type: Gene
Species: Mouse
Chromosome: 4
Pld2
Name: phospholipase D2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18806
HGNC: HGNC:9068
Homologene: 55672
Or4a74
Name: olfactory receptor family 4 subfamily A member 74
Synonyms: Olfr1247, MOR231-6, GA_x6K02T2Q125-51051555-51050611
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258968
Homologene: 121536
Sipa1
Name: signal-induced proliferation associated gene 1
Synonyms: SPA-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20469
VEGA: 19
Homologene: 7940
Myom3
Name: myomesin family, member 3
Synonyms: 8430427K15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242702
Homologene: 19432
Hmgn1
Name: high mobility group nucleosomal binding domain 1
Synonyms: HMG-14, Hmg14
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15312
HGNC: HGNC:4984
Homologene: 3643
Far2
Name: fatty acyl CoA reductase 2
Synonyms: Mlstd1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330450
Homologene: 69247
Or5ae1
Name: olfactory receptor family 5 subfamily AE member 1
Synonyms: MOR254-1, Olfr290, GA_x6K02T2NHDJ-11170115-11169168
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258411
Homologene: 83130
Klhl29
Name: kelch-like 29
Synonyms: Kbtbd9, A230106N14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208439
VEGA: 12
Homologene: 66272
Cyp2d9
Name: cytochrome P450, family 2, subfamily d, polypeptide 9
Synonyms: testosterone 16alpha-hydroxylase, Cyp2d, P450-2D
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13105
VEGA: 15
Homologene: 86099
Hamp2
Name: hepcidin antimicrobial peptide 2
Synonyms: HEPC2, 1810073K19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66438
Homologene: 10911
Or51af1
Name: olfactory receptor family 51 subfamily AF member 1
Synonyms: MOR9-1, Olfr609, GA_x6K02T2PBJ9-6207735-6206776
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259086
Homologene: 64952
Iqcn
Name: IQ motif containing N
Synonyms: Gm16486
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 637079
Homologene: 141171
Krtap22-2
Name: keratin associated protein 22-2
Synonyms: 1110032D16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68740
VEGA: 16
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 53,635,317 bp
  • A to G, chromosome 1 at 55,081,763 bp
  • T to C, chromosome 2 at 4,884,591 bp
  • T to A, chromosome 2 at 26,945,805 bp
  • T to C, chromosome 2 at 77,896,350 bp
  • C to T, chromosome 2 at 89,610,022 bp
  • G to A, chromosome 3 at 116,772,472 bp
  • G to T, chromosome 4 at 11,795,685 bp
  • A to T, chromosome 4 at 34,805,982 bp
  • A to G, chromosome 4 at 124,610,523 bp
  • A to G, chromosome 4 at 135,796,296 bp
  • C to G, chromosome 4 at 144,555,293 bp
  • A to G, chromosome 5 at 92,422,408 bp
  • T to A, chromosome 6 at 71,974,848 bp
  • C to T, chromosome 6 at 92,807,163 bp
  • T to A, chromosome 6 at 148,165,635 bp
  • T to C, chromosome 7 at 19,710,778 bp
  • A to C, chromosome 7 at 28,562,544 bp
  • A to G, chromosome 7 at 30,922,549 bp
  • A to G, chromosome 7 at 82,428,434 bp
  • T to A, chromosome 7 at 84,916,463 bp
  • T to C, chromosome 7 at 103,492,312 bp
  • T to G, chromosome 7 at 141,816,926 bp
  • T to A, chromosome 8 at 3,633,914 bp
  • T to C, chromosome 8 at 70,709,723 bp
  • T to A, chromosome 8 at 120,669,371 bp
  • T to A, chromosome 8 at 128,713,406 bp
  • C to A, chromosome 9 at 3,430,723 bp
  • A to G, chromosome 9 at 71,858,505 bp
  • A to T, chromosome 9 at 71,922,787 bp
  • T to A, chromosome 9 at 100,890,922 bp
  • T to C, chromosome 11 at 8,855,567 bp
  • T to A, chromosome 11 at 34,054,354 bp
  • C to T, chromosome 11 at 70,553,449 bp
  • C to A, chromosome 11 at 72,755,706 bp
  • T to A, chromosome 11 at 74,289,228 bp
  • T to A, chromosome 11 at 78,301,912 bp
  • T to A, chromosome 11 at 94,068,090 bp
  • A to T, chromosome 12 at 5,090,681 bp
  • C to T, chromosome 12 at 30,006,602 bp
  • T to C, chromosome 12 at 31,709,830 bp
  • T to C, chromosome 12 at 118,299,454 bp
  • A to T, chromosome 13 at 74,744,661 bp
  • T to C, chromosome 13 at 95,660,205 bp
  • A to G, chromosome 14 at 26,693,602 bp
  • A to C, chromosome 14 at 64,031,846 bp
  • T to C, chromosome 15 at 27,919,237 bp
  • T to A, chromosome 15 at 44,518,174 bp
  • T to A, chromosome 15 at 66,681,937 bp
  • T to C, chromosome 15 at 82,455,075 bp
  • T to A, chromosome 15 at 94,341,066 bp
  • T to G, chromosome 15 at 102,093,681 bp
  • T to A, chromosome 16 at 89,010,626 bp
  • G to A, chromosome 16 at 96,127,340 bp
  • C to T, chromosome 19 at 5,660,952 bp
  • C to T, chromosome 19 at 25,078,084 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8709 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068563-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.