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Strain Name:
C57BL/6J-MtgxR8742Btlr/Mmmh
Stock Number:
068587-MU
Citation ID:
RRID:MMRRC_068587-MU
Other Names:
R8742 (G1)
Major Collection:

Strain Information

Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Fis1
Name: fission, mitochondrial 1
Synonyms: 2010003O14Rik, Ttc11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66437
Homologene: 41099
Fgr
Name: FGR proto-oncogene, Src family tyrosine kinase
Synonyms: Ali18, Mhdaali18
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14191
HGNC: HGNC:3697
Homologene: 3842
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21853
Homologene: 31206
Pard3
Name: par-3 family cell polarity regulator
Synonyms: ASIP, D8Ertd580e, PAR-3, Par3, Pard3a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93742
Homologene: 10489
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 5033407O22Rik, 4833414K03Rik, CHAK1, CHAK, TRP-PLIK, Ltpr7, 2310022G15Rik, LTRPC7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Gphn
Name: gephyrin
Synonyms: geph, 5730552E08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268566
VEGA: 12
Homologene: 10820
Cdc40
Name: cell division cycle 40
Synonyms: PRP17, EHB3, 1200003H23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71713
VEGA: 10
Homologene: 5716
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Shb
Name: src homology 2 domain-containing transforming protein B
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230126
Homologene: 74458
Gdf10
Name: growth differentiation factor 10
Synonyms: Bmp3b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14560
VEGA: 14
HGNC: HGNC:4215
Homologene: 3640
Atg16l1
Name: autophagy related 16 like 1
Synonyms: APG16L, WDR30, 1500009K01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77040
Homologene: 41786
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Hpf1
Name: histone PARylation factor 1
Synonyms: 2700029M09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72612
Homologene: 32374
Adnp2
Name: ADNP homeobox 2
Synonyms: Zfp508, 8430420L05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240442
Homologene: 8945
Vps11
Name: VPS11, CORVET/HOPS core subunit
Synonyms: 1200011A11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71732
VEGA: 9
Homologene: 6673
Uimc1
Name: ubiquitin interaction motif containing 1
Synonyms: D630032M02Rik, D330018D10Rik, 9430016E08Rik, Rxrip110
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20184
Homologene: 9455
Mcm4
Name: minichromosome maintenance complex component 4
Synonyms: mCdc21, Cdc21, Mcmd4, 19G
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17217
VEGA: 16
HGNC: HGNC:6947
Homologene: 40496
Slc38a9
Name: solute carrier family 38, member 9
Synonyms: 9430067K09Rik, 6720411P22Rik, 9130023D20Rik, 4833412L08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268706
VEGA: 13
Homologene: 18139
Serinc1
Name: serine incorporator 1
Synonyms: TMS-2, 1500011D18Rik, Tde1l, Tde2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56442
Homologene: 41334
Ncapg
Name: non-SMC condensin I complex, subunit G
Synonyms: MFT.M05.13, Hcapg, 5730507H05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54392
Homologene: 44071
Lbr
Name: lamin B receptor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98386
HGNC: HGNC:6518
Homologene: 2455
Dlat
Name: dihydrolipoamide S-acetyltransferase
Synonyms: PDC-E2, 6332404G05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235339
HGNC: HGNC:2896
Homologene: 6814
Ret
Name: ret proto-oncogene
Synonyms: RET51, RET9, c-Ret
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19713
HGNC: HGNC:9967
Homologene: 7517
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Synonyms: aldosterone receptor, Mlr, MR, mineralocorticoid receptor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110784
HGNC: HGNC:7979
Homologene: 121495
Ankrd35
Name: ankyrin repeat domain 35
Synonyms: 4732436F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213121
Homologene: 16977
Mapre2
Name: microtubule-associated protein, RP/EB family, member 2
Synonyms: D18Abb1e, RP1, EB2, C820009F03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 212307
HGNC: HGNC:6891
Homologene: 134539
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: A830096D10Rik, Bai3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, 9430031G15Rik, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Trim44
Name: tripartite motif-containing 44
Synonyms: DIPB, Mc7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80985
Homologene: 9731
Poteg
Name: POTE ankyrin domain family, member G
Synonyms: 4930456F22Rik, 4921537P18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70952
Homologene: 134158
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: Fish, Sh3md1, Tks5, 2310014D11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14218
VEGA: 19
Homologene: 7317
Ripk4
Name: receptor-interacting serine-threonine kinase 4
Synonyms: PKK, DIk, RIP4, ANKK2, Ankrd3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72388
HGNC: HGNC:496
Homologene: 10772
Sprr3
Name: small proline-rich protein 3
Synonyms: SPR3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20766
Homologene: 135951
Ifitm6
Name: interferon induced transmembrane protein 6
Synonyms: fragilis5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 213002
Homologene: 72556
Adhfe1
Name: alcohol dehydrogenase, iron containing, 1
Synonyms: 6330565B14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76187
Homologene: 5865
Vmn2r13
Name: vomeronasal 2, receptor 13
Synonyms: Gm4867
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231589
Homologene: 129606
Axl
Name: AXL receptor tyrosine kinase
Synonyms: Tyro7, Ark, Ufo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26362
HGNC: HGNC:905
Homologene: 7583
Mtnr1a
Name: melatonin receptor 1A
Synonyms: MelR, Mel1a receptor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17773
HGNC: HGNC:7463
Homologene: 21207
Or4k52
Name: olfactory receptor family 4 subfamily K member 52
Synonyms: GA_x6K02T2Q125-72831562-72832500, MOR248-3, Olfr1302
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258891
Homologene: 27290
Cfh
Name: complement component factor h
Synonyms: Sas-1, Mud-1, Sas1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Itgax
Name: integrin alpha X
Synonyms: CD11C (p150) alpha polypeptide, Cd11c, CR4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Slc36a4
Name: solute carrier family 36 (proton/amino acid symporter), member 4
Synonyms: PAT4, 6330573I15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234967
Homologene: 56300
Zp3r
Name: zona pellucida 3 receptor
Synonyms: SP56
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22789
HGNC: HGNC:1325
Homologene: 7609
Skint11
Name: selection and upkeep of intraepithelial T cells 11
Synonyms: A630098G03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230623
Homologene: 136292
Klhl3
Name: kelch-like 3
Synonyms: 7530408C15Rik, EG627648
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100503085
HGNC: HGNC:6354
Homologene: 79542
Filip1l
Name: filamin A interacting protein 1-like
Synonyms: 4631422O05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78749
Homologene: 37121
Gpr132
Name: G protein-coupled receptor 132
Synonyms: G2 accumulation, G2a
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56696
VEGA: 12
Homologene: 8350
Epn3
Name: epsin 3
Synonyms: 2310022G12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71889
Homologene: 56791
Mlf1
Name: myeloid leukemia factor 1
Synonyms: HLS7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17349
HGNC: HGNC:7125
Homologene: 7839
Ceacam13
Name: CEA cell adhesion molecule 13
Synonyms: Ceacam13-C2, Ceacam13-C1, 1600025J19Rik, 1600012K03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69785
HGNC: HGNC:1819
Homologene: 135962
Clic1
Name: chloride intracellular channel 1
Synonyms: G6, Clcp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 114584
HGNC: HGNC:2062
Homologene: 20343
G530012D18Rik
Name: RIKEN cDNA G530012D1 gene
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 9,560,176 bp
  • T to C, chromosome 1 at 25,226,754 bp
  • T to A, chromosome 1 at 34,212,344 bp
  • C to G, chromosome 1 at 85,577,214 bp
  • C to T, chromosome 1 at 87,766,898 bp
  • C to G, chromosome 1 at 90,767,606 bp
  • A to T, chromosome 1 at 130,583,493 bp
  • A to T, chromosome 1 at 140,101,652 bp
  • G to T, chromosome 1 at 140,136,731 bp
  • A to G, chromosome 1 at 181,817,006 bp
  • A to G, chromosome 2 at 102,400,176 bp
  • A to G, chromosome 2 at 111,780,565 bp
  • A to G, chromosome 2 at 126,825,549 bp
  • G to A, chromosome 3 at 67,397,786 bp
  • C to T, chromosome 3 at 92,457,000 bp
  • T to A, chromosome 3 at 96,679,186 bp
  • G to C, chromosome 4 at 45,458,319 bp
  • T to C, chromosome 4 at 114,194,725 bp
  • T to C, chromosome 4 at 132,997,517 bp
  • T to A, chromosome 5 at 45,693,874 bp
  • T to A, chromosome 5 at 93,638,076 bp
  • T to C, chromosome 5 at 109,156,397 bp
  • G to T, chromosome 5 at 136,953,511 bp
  • A to T, chromosome 6 at 118,178,523 bp
  • T to A, chromosome 7 at 18,010,009 bp
  • A to G, chromosome 7 at 25,764,436 bp
  • C to A, chromosome 7 at 56,094,395 bp
  • CGGCGGCGGCGGCGGCGGCGGC to CGGCGGCGGCGGCGGCGGCGGCGGCGGCGGC, chromosome 7 at 97,579,914 bp
  • A to T, chromosome 7 at 128,144,623 bp
  • A to G, chromosome 7 at 131,182,012 bp
  • A to G, chromosome 7 at 141,016,095 bp
  • A to T, chromosome 8 at 27,494,929 bp
  • A to G, chromosome 8 at 45,087,683 bp
  • T to C, chromosome 8 at 60,893,714 bp
  • T to G, chromosome 8 at 76,908,581 bp
  • C to T, chromosome 8 at 127,324,111 bp
  • A to G, chromosome 9 at 15,720,743 bp
  • A to G, chromosome 9 at 44,355,773 bp
  • G to T, chromosome 9 at 50,649,667 bp
  • A to T, chromosome 10 at 5,108,661 bp
  • C to T, chromosome 10 at 40,841,484 bp
  • A to T, chromosome 10 at 57,519,799 bp
  • A to T, chromosome 10 at 128,247,238 bp
  • T to G, chromosome 11 at 94,496,095 bp
  • C to T, chromosome 12 at 78,612,992 bp
  • T to C, chromosome 12 at 112,855,897 bp
  • A to G, chromosome 13 at 55,093,158 bp
  • T to C, chromosome 13 at 58,011,207 bp
  • T to A, chromosome 13 at 112,729,284 bp
  • A to T, chromosome 14 at 33,932,469 bp
  • T to C, chromosome 16 at 15,625,566 bp
  • A to G, chromosome 16 at 57,571,230 bp
  • A to T, chromosome 16 at 97,755,072 bp
  • A to T, chromosome 17 at 25,745,073 bp
  • A to G, chromosome 17 at 35,055,380 bp
  • A to G, chromosome 17 at 75,310,222 bp
  • C to A, chromosome 18 at 23,883,631 bp
  • A to G, chromosome 18 at 80,128,341 bp
  • G to A, chromosome 19 at 47,286,634 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8742 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068587-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.