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Strain Name:
C57BL/6J-MtgxR9087Btlr/Mmmh
Stock Number:
068906-MU
Citation ID:
RRID:MMRRC_068906-MU
Other Names:
R9087 (G1)
Major Collection:

Strain Information

Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Gcm2
Name: glial cells missing homolog 2
Synonyms: Gcm1-rs2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107889
VEGA: 13
HGNC: HGNC:4198
Homologene: 3490
Ep400
Name: E1A binding protein p400
Synonyms: p400, mDomino, 1700020J09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Barhl1
Name: BarH like homeobox 1
Synonyms: Dres115, MBH2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54422
HGNC: HGNC:953
Homologene: 81871
Slc2a3
Name: solute carrier family 2 (facilitated glucose transporter), member 3
Synonyms: Glut-3, Glut3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20527
Homologene: 74302
Bbx
Name: bobby sox HMG box containing
Synonyms: 5730403O13Rik, 5530401J07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70508
Homologene: 10634
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 4,923,967 bp
  • T to A, chromosome 1 at 45,442,658 bp
  • A to T, chromosome 1 at 75,173,567 bp
  • A to G, chromosome 1 at 132,525,370 bp
  • A to G, chromosome 1 at 134,312,588 bp
  • T to C, chromosome 1 at 135,974,868 bp
  • T to C, chromosome 2 at 28,915,219 bp
  • T to C, chromosome 2 at 36,569,333 bp
  • A to C, chromosome 2 at 38,021,354 bp
  • A to C, chromosome 2 at 84,609,578 bp
  • A to G, chromosome 2 at 86,255,036 bp
  • A to G, chromosome 2 at 87,071,955 bp
  • A to T, chromosome 2 at 90,684,085 bp
  • A to T, chromosome 2 at 164,429,039 bp
  • C to A, chromosome 3 at 55,642,736 bp
  • A to G, chromosome 3 at 99,216,747 bp
  • T to C, chromosome 3 at 108,904,341 bp
  • A to G, chromosome 3 at 142,352,833 bp
  • G to T, chromosome 3 at 151,745,880 bp
  • C to T, chromosome 4 at 43,568,304 bp
  • A to G, chromosome 4 at 98,736,462 bp
  • A to G, chromosome 4 at 116,291,734 bp
  • A to T, chromosome 4 at 136,052,689 bp
  • T to C, chromosome 5 at 43,281,118 bp
  • C to T, chromosome 5 at 87,254,137 bp
  • A to T, chromosome 5 at 110,667,564 bp
  • T to G, chromosome 5 at 145,032,278 bp
  • A to G, chromosome 5 at 150,988,492 bp
  • A to C, chromosome 6 at 18,214,181 bp
  • T to G, chromosome 6 at 42,141,234 bp
  • A to G, chromosome 6 at 88,497,373 bp
  • A to G, chromosome 6 at 118,559,269 bp
  • A to T, chromosome 6 at 122,581,741 bp
  • A to G, chromosome 6 at 122,740,449 bp
  • G to T, chromosome 6 at 125,137,428 bp
  • T to C, chromosome 7 at 45,651,069 bp
  • C to A, chromosome 7 at 46,083,324 bp
  • A to T, chromosome 7 at 47,464,770 bp
  • A to G, chromosome 7 at 55,817,358 bp
  • A to T, chromosome 7 at 98,126,324 bp
  • A to G, chromosome 7 at 102,659,757 bp
  • C to T, chromosome 7 at 105,024,703 bp
  • A to G, chromosome 7 at 108,346,751 bp
  • A to T, chromosome 7 at 140,400,634 bp
  • T to C, chromosome 8 at 14,033,623 bp
  • G to A, chromosome 8 at 45,275,478 bp
  • A to G, chromosome 8 at 69,803,807 bp
  • T to C, chromosome 8 at 70,789,686 bp
  • T to A, chromosome 8 at 71,492,355 bp
  • G to A, chromosome 8 at 84,638,803 bp
  • A to G, chromosome 8 at 105,728,219 bp
  • A to G, chromosome 8 at 111,041,537 bp
  • T to C, chromosome 9 at 7,579,857 bp
  • A to G, chromosome 9 at 38,665,415 bp
  • C to G, chromosome 9 at 70,802,108 bp
  • T to C, chromosome 10 at 18,531,282 bp
  • C to G, chromosome 10 at 80,357,996 bp
  • T to A, chromosome 11 at 3,717,976 bp
  • T to C, chromosome 11 at 98,003,007 bp
  • T to C, chromosome 11 at 105,981,919 bp
  • T to C, chromosome 11 at 114,959,765 bp
  • T to A, chromosome 12 at 21,308,994 bp
  • C to T, chromosome 12 at 69,702,357 bp
  • T to A, chromosome 12 at 73,942,325 bp
  • C to A, chromosome 13 at 37,931,668 bp
  • C to G, chromosome 13 at 41,109,930 bp
  • T to C, chromosome 13 at 43,200,362 bp
  • C to A, chromosome 13 at 54,524,334 bp
  • T to C, chromosome 13 at 64,751,718 bp
  • T to C, chromosome 13 at 93,097,203 bp
  • T to C, chromosome 14 at 26,824,546 bp
  • C to A, chromosome 14 at 54,468,164 bp
  • A to G, chromosome 14 at 98,168,831 bp
  • A to T, chromosome 15 at 35,300,864 bp
  • C to T, chromosome 15 at 58,939,302 bp
  • T to G, chromosome 15 at 74,957,800 bp
  • G to T, chromosome 15 at 103,315,891 bp
  • G to A, chromosome 16 at 20,211,750 bp
  • A to G, chromosome 16 at 29,618,235 bp
  • A to T, chromosome 16 at 32,806,760 bp
  • T to C, chromosome 16 at 50,274,635 bp
  • A to G, chromosome 17 at 24,724,185 bp
  • G to A, chromosome 17 at 27,118,677 bp
  • T to A, chromosome 18 at 25,504,270 bp
  • T to C, chromosome 18 at 35,800,144 bp
  • T to C, chromosome 18 at 84,209,857 bp
  • A to T, chromosome 19 at 53,383,643 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9087 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068906-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.