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Strain Name:
C57BL/6J-MtgxR9103Btlr/Mmmh
Stock Number:
068999-MU
Citation ID:
RRID:MMRRC_068999-MU
Other Names:
R9103 (G1)
Major Collection:

Strain Information

Sim1
Name: single-minded family bHLH transcription factor 1
Synonyms: bHLHe14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20464
VEGA: 10
Homologene: 3715
Pax2
Name: paired box 2
Synonyms: Pax-2, Opdc
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18504
HGNC: HGNC:8616
Homologene: 2968
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NMDAR-L, NR3A, A830097C19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Mthfd1
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
Synonyms: Mthfd, DCS, E430024A07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108156
VEGA: 12
HGNC: HGNC:7432
Homologene: 55940
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Lrrfip2
Name: leucine rich repeat (in FLII) interacting protein 2
Synonyms: 5133400F20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71268
HGNC: HGNC:6703
Homologene: 22476
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to A, chromosome 1 at 58,257,282 bp (GRCm38)
  • C to T, chromosome 1 at 167,308,563 bp (GRCm38)
  • T to A, chromosome 2 at 11,482,570 bp (GRCm38)
  • T to A, chromosome 2 at 85,722,183 bp (GRCm38)
  • A to G, chromosome 2 at 88,461,598 bp (GRCm38)
  • A to G, chromosome 2 at 90,777,843 bp (GRCm38)
  • T to C, chromosome 3 at 40,760,917 bp (GRCm38)
  • A to G, chromosome 3 at 58,545,040 bp (GRCm38)
  • T to C, chromosome 3 at 92,584,531 bp (GRCm38)
  • C to T, chromosome 3 at 97,841,728 bp (GRCm38)
  • T to C, chromosome 3 at 106,490,368 bp (GRCm38)
  • T to A, chromosome 3 at 142,304,413 bp (GRCm38)
  • A to G, chromosome 4 at 49,771,179 bp (GRCm38)
  • G to A, chromosome 4 at 143,897,811 bp (GRCm38)
  • A to C, chromosome 4 at 152,376,987 bp (GRCm38)
  • G to A, chromosome 5 at 35,517,710 bp (GRCm38)
  • G to A, chromosome 5 at 112,378,039 bp (GRCm38)
  • A to T, chromosome 5 at 120,532,874 bp (GRCm38)
  • A to G, chromosome 6 at 58,472,088 bp (GRCm38)
  • T to A, chromosome 6 at 136,401,013 bp (GRCm38)
  • C to A, chromosome 6 at 142,376,789 bp (GRCm38)
  • G to C, chromosome 7 at 4,143,898 bp (GRCm38)
  • A to G, chromosome 7 at 27,328,761 bp (GRCm38)
  • T to A, chromosome 7 at 30,557,630 bp (GRCm38)
  • T to A, chromosome 7 at 56,135,055 bp (GRCm38)
  • A to T, chromosome 7 at 108,565,573 bp (GRCm38)
  • A to T, chromosome 7 at 109,727,920 bp (GRCm38)
  • T to A, chromosome 7 at 132,982,438 bp (GRCm38)
  • G to A, chromosome 8 at 27,113,408 bp (GRCm38)
  • G to T, chromosome 8 at 44,951,813 bp (GRCm38)
  • A to G, chromosome 8 at 94,019,693 bp (GRCm38)
  • A to G, chromosome 8 at 105,856,148 bp (GRCm38)
  • A to T, chromosome 9 at 35,546,789 bp (GRCm38)
  • A to T, chromosome 9 at 38,292,673 bp (GRCm38)
  • A to G, chromosome 9 at 38,403,222 bp (GRCm38)
  • A to T, chromosome 9 at 111,205,772 bp (GRCm38)
  • T to A, chromosome 10 at 50,909,429 bp (GRCm38)
  • C to T, chromosome 10 at 78,405,042 bp (GRCm38)
  • G to A, chromosome 10 at 127,595,110 bp (GRCm38)
  • A to G, chromosome 10 at 127,998,007 bp (GRCm38)
  • A to G, chromosome 11 at 6,516,153 bp (GRCm38)
  • A to G, chromosome 11 at 16,953,556 bp (GRCm38)
  • C to A, chromosome 11 at 52,773,869 bp (GRCm38)
  • A to G, chromosome 11 at 58,206,900 bp (GRCm38)
  • T to G, chromosome 11 at 60,763,427 bp (GRCm38)
  • A to T, chromosome 11 at 67,098,625 bp (GRCm38)
  • T to A, chromosome 11 at 69,945,392 bp (GRCm38)
  • T to C, chromosome 11 at 71,783,419 bp (GRCm38)
  • A to G, chromosome 11 at 79,559,506 bp (GRCm38)
  • A to G, chromosome 11 at 101,181,268 bp (GRCm38)
  • A to G, chromosome 11 at 103,360,714 bp (GRCm38)
  • T to C, chromosome 12 at 64,943,526 bp (GRCm38)
  • T to C, chromosome 12 at 73,109,190 bp (GRCm38)
  • T to A, chromosome 12 at 76,303,743 bp (GRCm38)
  • T to A, chromosome 12 at 81,378,715 bp (GRCm38)
  • T to A, chromosome 12 at 113,490,938 bp (GRCm38)
  • A to G, chromosome 13 at 24,111,853 bp (GRCm38)
  • T to C, chromosome 13 at 67,316,612 bp (GRCm38)
  • T to A, chromosome 13 at 98,355,255 bp (GRCm38)
  • G to A, chromosome 14 at 29,347,014 bp (GRCm38)
  • A to G, chromosome 14 at 31,369,775 bp (GRCm38)
  • T to C, chromosome 14 at 47,016,609 bp (GRCm38)
  • T to C, chromosome 14 at 56,261,165 bp (GRCm38)
  • C to T, chromosome 14 at 121,271,692 bp (GRCm38)
  • A to G, chromosome 15 at 6,643,751 bp (GRCm38)
  • A to T, chromosome 17 at 7,933,503 bp (GRCm38)
  • A to G, chromosome 17 at 14,954,120 bp (GRCm38)
  • C to T, chromosome 17 at 34,614,236 bp (GRCm38)
  • G to A, chromosome 18 at 32,220,572 bp (GRCm38)
  • T to C, chromosome 18 at 58,572,196 bp (GRCm38)
  • C to T, chromosome 19 at 6,958,920 bp (GRCm38)
  • T to A, chromosome 19 at 39,739,181 bp (GRCm38)
  • C to T, chromosome 19 at 44,818,529 bp (GRCm38)
  • A to C, chromosome 19 at 55,328,433 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9103 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068999-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.