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Strain Name:
C57BL/6J-MtgxR9257Btlr/Mmmh
Stock Number:
069079-MU
Citation ID:
RRID:MMRRC_069079-MU
Other Names:
R9257 (G1)
Major Collection:

Strain Information

Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21366
Homologene: 2291
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: Bravo, C030017F07Rik, C130076O07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Prdm16
Name: PR domain containing 16
Synonyms: Mel1, 5730557K01Rik, line 27, csp1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70673
Homologene: 11139
Upp1
Name: uridine phosphorylase 1
Synonyms: UdRPase, UPase, Up
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22271
Homologene: 2524
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: Daple, 0610010D24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to T, chromosome 1 at 23,102,194 bp (GRCm38)
  • A to G, chromosome 1 at 30,946,265 bp (GRCm38)
  • G to A, chromosome 1 at 63,306,241 bp (GRCm38)
  • C to T, chromosome 1 at 91,448,723 bp (GRCm38)
  • A to G, chromosome 1 at 106,172,551 bp (GRCm38)
  • C to T, chromosome 1 at 167,308,563 bp (GRCm38)
  • A to T, chromosome 1 at 173,862,708 bp (GRCm38)
  • T to C, chromosome 2 at 25,824,772 bp (GRCm38)
  • T to G, chromosome 2 at 32,033,335 bp (GRCm38)
  • T to A, chromosome 2 at 49,700,592 bp (GRCm38)
  • A to G, chromosome 2 at 140,660,239 bp (GRCm38)
  • T to A, chromosome 2 at 151,473,707 bp (GRCm38)
  • T to C, chromosome 2 at 165,354,054 bp (GRCm38)
  • T to A, chromosome 2 at 174,646,363 bp (GRCm38)
  • T to A, chromosome 3 at 87,435,888 bp (GRCm38)
  • G to T, chromosome 3 at 87,924,461 bp (GRCm38)
  • A to C, chromosome 3 at 94,403,369 bp (GRCm38)
  • C to A, chromosome 3 at 95,681,265 bp (GRCm38)
  • A to G, chromosome 4 at 24,649,608 bp (GRCm38)
  • T to C, chromosome 4 at 41,499,030 bp (GRCm38)
  • T to A, chromosome 4 at 143,699,115 bp (GRCm38)
  • A to T, chromosome 4 at 154,337,698 bp (GRCm38)
  • T to A, chromosome 5 at 33,026,751 bp (GRCm38)
  • A to T, chromosome 5 at 96,762,500 bp (GRCm38)
  • A to T, chromosome 5 at 101,815,885 bp (GRCm38)
  • A to G, chromosome 5 at 115,083,473 bp (GRCm38)
  • A to T, chromosome 5 at 117,325,066 bp (GRCm38)
  • G to A, chromosome 5 at 127,784,427 bp (GRCm38)
  • G to T, chromosome 5 at 151,062,491 bp (GRCm38)
  • C to T, chromosome 6 at 32,162,083 bp (GRCm38)
  • T to A, chromosome 6 at 40,491,658 bp (GRCm38)
  • T to A, chromosome 6 at 83,070,054 bp (GRCm38)
  • T to A, chromosome 6 at 91,739,971 bp (GRCm38)
  • C to A, chromosome 6 at 116,216,108 bp (GRCm38)
  • A to T, chromosome 7 at 97,685,711 bp (GRCm38)
  • A to T, chromosome 7 at 133,691,124 bp (GRCm38)
  • T to A, chromosome 7 at 141,640,471 bp (GRCm38)
  • A to T, chromosome 8 at 28,725,146 bp (GRCm38)
  • T to A, chromosome 8 at 72,670,938 bp (GRCm38)
  • A to T, chromosome 8 at 110,575,016 bp (GRCm38)
  • G to A, chromosome 9 at 15,996,567 bp (GRCm38)
  • A to G, chromosome 9 at 53,495,850 bp (GRCm38)
  • T to A, chromosome 9 at 65,267,169 bp (GRCm38)
  • T to C, chromosome 9 at 98,865,245 bp (GRCm38)
  • C to A, chromosome 9 at 105,414,652 bp (GRCm38)
  • T to A, chromosome 9 at 110,894,687 bp (GRCm38)
  • A to T, chromosome 10 at 77,989,655 bp (GRCm38)
  • C to A, chromosome 10 at 129,691,134 bp (GRCm38)
  • A to T, chromosome 11 at 9,125,661 bp (GRCm38)
  • T to C, chromosome 11 at 32,210,754 bp (GRCm38)
  • T to C, chromosome 11 at 59,205,752 bp (GRCm38)
  • T to A, chromosome 11 at 74,817,301 bp (GRCm38)
  • A to G, chromosome 11 at 96,857,560 bp (GRCm38)
  • T to A, chromosome 12 at 44,564,054 bp (GRCm38)
  • A to G, chromosome 12 at 65,133,857 bp (GRCm38)
  • G to A, chromosome 12 at 100,923,215 bp (GRCm38)
  • T to C, chromosome 13 at 55,168,161 bp (GRCm38)
  • T to C, chromosome 13 at 61,536,599 bp (GRCm38)
  • G to T, chromosome 14 at 55,545,245 bp (GRCm38)
  • A to T, chromosome 15 at 55,066,013 bp (GRCm38)
  • A to C, chromosome 15 at 58,029,018 bp (GRCm38)
  • C to T, chromosome 15 at 76,600,792 bp (GRCm38)
  • T to A, chromosome 15 at 85,815,897 bp (GRCm38)
  • T to C, chromosome 15 at 91,191,112 bp (GRCm38)
  • C to T, chromosome 15 at 101,816,491 bp (GRCm38)
  • T to C, chromosome 16 at 10,835,225 bp (GRCm38)
  • C to A, chromosome 16 at 14,269,256 bp (GRCm38)
  • A to G, chromosome 17 at 34,931,420 bp (GRCm38)
  • G to T, chromosome 17 at 56,620,516 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9257 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069079-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.