Strain Name:
C57BL/6J-MtgxR9422Btlr/Mmmh
Stock Number:
069226-MU
Citation ID:
RRID:MMRRC_069226-MU
Other Names:
R9422 (G1)
Major Collection:

Strain Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Becn1
Name: beclin 1, autophagy related
Synonyms: Atg6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56208
HGNC: HGNC:1034
Homologene: 2794
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50492
Homologene: 55726
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Clasp1
Name: CLIP associating protein 1
Synonyms: CLASP1alpha, CLASP1, mCLASP1, 1700030C23Rik, 5730583A19Rik, B130045P17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76707
Homologene: 41024
H2bc3
Name: H2B clustered histone 3
Synonyms: H2b-143, Hist1h2bb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319178
Homologene: 137348
Rpap1
Name: RNA polymerase II associated protein 1
Synonyms: 1190005L06Rik, A730023M06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68925
Homologene: 32269
Zfhx3
Name: zinc finger homeobox 3
Synonyms: A230102L03Rik, Atbf1, Sci, WBP9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Dctn1
Name: dynactin 1
Synonyms: Glued, p150glued, p150
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13191
HGNC: HGNC:2711
Homologene: 3011
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, Dopey1, B130005I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22019
Homologene: 2471
Dcp2
Name: decapping mRNA 2
Synonyms: 5730537H01Rik, 2410015D23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70640
Homologene: 13968
Skic3
Name: SKI3 subunit of superkiller complex
Synonyms: Ttc37
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218343
VEGA: 13
Homologene: 40966
Socs7
Name: suppressor of cytokine signaling 7
Synonyms: 2310063P06Rik, Nap4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192157
Homologene: 16331
Pgm3
Name: phosphoglucomutase 3
Synonyms: 2810473H05Rik, Pgm-3, GlcNAc-P mutase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109785
HGNC: HGNC:8907
Homologene: 9205
Rgs2
Name: regulator of G-protein signaling 2
Synonyms: GOS8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19735
HGNC: HGNC:9998
Homologene: 2192
Robo3
Name: roundabout guidance receptor 3
Synonyms: Robo3a, Rbig1, Rig1, Rig-1, Robo3b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19649
Homologene: 32119
Ipmk
Name: inositol polyphosphate multikinase
Synonyms: 2410017C19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69718
Homologene: 76214
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Zfp667
Name: zinc finger protein 667
Synonyms: A830025F02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384763
Homologene: 23343
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Prkaa2
Name: protein kinase, AMP-activated, alpha 2 catalytic subunit
Synonyms: AMPKalpha2, 2310008I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108079
HGNC: HGNC:9377
Homologene: 4551
Milr1
Name: mast cell immunoglobulin like receptor 1
Synonyms: LOC380732, Gm885, Allergin-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380732
Homologene: 86017
Nell1
Name: NEL-like 1
Synonyms: l7R6, B230343H07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Slc4a8
Name: solute carrier family 4 (anion exchanger), member 8
Synonyms: NDCBE, KNBC-3, sodium bicarbonate cotransporter isoform 3 kNBC-3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 59033
Homologene: 68419
Vipr1
Name: vasoactive intestinal peptide receptor 1
Synonyms: VIP-R1, VIP receptor subtype 1, VPAC1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22354
Homologene: 3399
Ralgds
Name: ral guanine nucleotide dissociation stimulator
Synonyms: Gnds, Rgds, RalGDS
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19730
HGNC: HGNC:9842
Homologene: 4562
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207686
Homologene: 11718
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: Anr1, OATP-D, 5830414C08Rik, Slc21a11, MJAM
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108116
Homologene: 40862
4930562C15Rik
Name: RIKEN cDNA 4930562C15 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78809
Homologene: 53527
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: alphaA-CRYBP1, Cryabp1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Fbxo2
Name: F-box protein 2
Synonyms: FBX2, NFB42, Fbs1, Prpl4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230904
Homologene: 8132
B3galnt2
Name: UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2
Synonyms: D230016N13Rik, A930105D20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97884
VEGA: 13
Homologene: 17595
Odad3
Name: outer dynein arm docking complex subunit 3
Synonyms: C330001K17Rik, b2b1885Clo, Ccdc151
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77609
VEGA: 9
Homologene: 16533
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Vmn1r27
Name: vomeronasal 1 receptor 27
Synonyms: V1rc33
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171206
Homologene: 79462
Adamts18
Name: ADAM metallopeptidase with thrombospondin type 1 motif 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 208936
Homologene: 65241
Nme8
Name: NME/NM23 family member 8
Synonyms: 1700056P15Rik, Txndc3, Sptrx-2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73412
Homologene: 9593
Pramel22
Name: PRAME like 22
Synonyms: Gm13088
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277668
Homologene: 129883
Pex5l
Name: peroxisomal biogenesis factor 5-like
Synonyms: PXR2, Pex2, 1700016J08Rik, TRIP8b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 58869
Homologene: 9562
Adgrg6
Name: adhesion G protein-coupled receptor G6
Synonyms: Gpr126, LOC215798, 1190004A11Rik, DREG
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215798
Homologene: 10724
Ccdc57
Name: coiled-coil domain containing 57
Synonyms: 4933434G05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71276
Homologene: 52351
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665255
Homologene: 129605
Vmn1r233
Name: vomeronasal 1 receptor 233
Synonyms: V1rf5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171236
Homologene: 128343
Gzmg
Name: granzyme G
Synonyms: Ctla-7, Ctla7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14944
VEGA: 14
Homologene: 133275
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627367
Homologene: 115024
Zhx3
Name: zinc fingers and homeoboxes 3
Synonyms: 1810059C13Rik, 9530010N21Rik, Tix1, 4932418O04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320799
Homologene: 9000
Or7g35
Name: olfactory receptor family 7 subfamily G member 35
Synonyms: MOR148-1, Olfr855, GA_x6K02T2PVTD-13330461-13331399
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258517
HGNC: HGNC:8466
Homologene: 74176
Csn3
Name: casein kappa
Synonyms: Csnk, CSN10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12994
HGNC: HGNC:2446
Homologene: 3818
Zhx1
Name: zinc fingers and homeoboxes 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22770
Homologene: 5225
Cmtm3
Name: CKLF-like MARVEL transmembrane domain containing 3
Synonyms: Cklfsf3, 9430096L06Rik, BNAS2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68119
Homologene: 11486
Slc26a8
Name: solute carrier family 26, member 8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224661
Homologene: 27095
R3hdml
Name: R3H domain containing-like
Synonyms: OTTMUSG00000001070
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100043899
Homologene: 45608
Aipl1
Name: aryl hydrocarbon receptor-interacting protein-like 1
Synonyms: A930007I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 114230
HGNC: HGNC:359
Homologene: 22806
Cd302
Name: CD302 antigen
Synonyms: 1110055L24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66205
Homologene: 8919
Or5p75-ps1
Name: olfactory receptor family 5 subfamily P member 75, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-10838051-10838996, Olfr501-ps1, MOR204-27P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258054
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 43,978,737 bp (GRCm38)
  • T to A, chromosome 1 at 118,462,527 bp (GRCm38)
  • T to C, chromosome 1 at 144,003,045 bp (GRCm38)
  • T to A, chromosome 1 at 194,644,422 bp (GRCm38)
  • A to G, chromosome 2 at 28,545,172 bp (GRCm38)
  • T to C, chromosome 2 at 59,807,589 bp (GRCm38)
  • T to C, chromosome 2 at 60,252,353 bp (GRCm38)
  • G to A, chromosome 2 at 119,783,038 bp (GRCm38)
  • C to T, chromosome 2 at 160,782,100 bp (GRCm38)
  • A to G, chromosome 2 at 163,492,606 bp (GRCm38)
  • T to C, chromosome 3 at 33,082,252 bp (GRCm38)
  • A to G, chromosome 3 at 98,147,352 bp (GRCm38)
  • C to A, chromosome 3 at 127,096,856 bp (GRCm38)
  • A to T, chromosome 4 at 47,293,364 bp (GRCm38)
  • A to G, chromosome 4 at 105,051,998 bp (GRCm38)
  • T to A, chromosome 4 at 143,656,412 bp (GRCm38)
  • T to C, chromosome 4 at 148,164,159 bp (GRCm38)
  • A to G, chromosome 5 at 5,649,851 bp (GRCm38)
  • A to G, chromosome 5 at 87,930,013 bp (GRCm38)
  • T to C, chromosome 6 at 58,215,882 bp (GRCm38)
  • T to A, chromosome 6 at 83,193,709 bp (GRCm38)
  • A to G, chromosome 7 at 5,480,748 bp (GRCm38)
  • A to G, chromosome 7 at 6,305,322 bp (GRCm38)
  • C to A, chromosome 7 at 50,062,639 bp (GRCm38)
  • C to T, chromosome 7 at 74,297,248 bp (GRCm38)
  • A to T, chromosome 7 at 108,508,948 bp (GRCm38)
  • A to T, chromosome 8 at 104,340,726 bp (GRCm38)
  • G to T, chromosome 8 at 104,340,727 bp (GRCm38)
  • C to T, chromosome 8 at 108,704,218 bp (GRCm38)
  • T to A, chromosome 8 at 113,775,278 bp (GRCm38)
  • T to C, chromosome 9 at 18,641,806 bp (GRCm38)
  • T to A, chromosome 9 at 19,584,672 bp (GRCm38)
  • T to A, chromosome 9 at 22,002,332 bp (GRCm38)
  • T to C, chromosome 9 at 37,418,493 bp (GRCm38)
  • C to T, chromosome 9 at 86,543,040 bp (GRCm38)
  • A to T, chromosome 9 at 86,561,885 bp (GRCm38)
  • G to A, chromosome 9 at 121,642,927 bp (GRCm38)
  • C to T, chromosome 10 at 14,426,996 bp (GRCm38)
  • T to C, chromosome 10 at 71,376,720 bp (GRCm38)
  • C to T, chromosome 10 at 81,080,167 bp (GRCm38)
  • C to T, chromosome 11 at 72,037,427 bp (GRCm38)
  • A to G, chromosome 11 at 97,363,147 bp (GRCm38)
  • C to A, chromosome 11 at 101,302,006 bp (GRCm38)
  • T to A, chromosome 11 at 106,766,979 bp (GRCm38)
  • T to C, chromosome 11 at 120,873,618 bp (GRCm38)
  • A to G, chromosome 13 at 13,975,551 bp (GRCm38)
  • A to G, chromosome 13 at 19,675,748 bp (GRCm38)
  • A to G, chromosome 13 at 23,746,957 bp (GRCm38)
  • A to G, chromosome 13 at 42,159,737 bp (GRCm38)
  • A to T, chromosome 13 at 76,130,328 bp (GRCm38)
  • T to A, chromosome 14 at 56,158,355 bp (GRCm38)
  • T to C, chromosome 15 at 58,052,675 bp (GRCm38)
  • A to T, chromosome 15 at 100,800,588 bp (GRCm38)
  • G to A, chromosome 16 at 4,849,289 bp (GRCm38)
  • T to A, chromosome 17 at 18,929,071 bp (GRCm38)
  • T to A, chromosome 17 at 20,993,807 bp (GRCm38)
  • T to C, chromosome 17 at 28,638,586 bp (GRCm38)
  • C to T, chromosome 18 at 44,405,294 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9422 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069226-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.