Strain Name:
C57BL/6J-MtgxR9539Btlr/Mmmh
Stock Number:
069338-MU
Citation ID:
RRID:MMRRC_069338-MU
Other Names:
R9539 (G1)
Major Collection:

Strain Information

Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Slit3
Name: slit guidance ligand 3
Synonyms: b2b2362.1Clo, Slit1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: 0610010D24Rik, Daple
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Tmem63b
Name: transmembrane protein 63b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224807
Homologene: 101682
Cep290
Name: centrosomal protein 290
Synonyms: Kiaa, b2b1454Clo, b2b1752Clo, Nphp6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Zc3h11a
Name: zinc finger CCCH type containing 11A
Synonyms: G630041M05Rik, 1110003F06Rik, 5730454B08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70579
Homologene: 8888
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Cog6
Name: component of oligomeric golgi complex 6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67542
Homologene: 10802
Dph5
Name: diphthamide biosynthesis 5
Synonyms: 2410012M04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69740
Homologene: 6471
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: D330037A14Rik, LL5A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102693
Homologene: 15903
Pf4
Name: platelet factor 4
Synonyms: Cxcl4, Scyb4, Pf4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56744
Homologene: 87791
Ppp1r15a
Name: protein phosphatase 1, regulatory subunit 15A
Synonyms: Gadd34, Myd116
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17872
Homologene: 8639
Traf7
Name: TNF receptor-associated factor 7
Synonyms: RFWD1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224619
Homologene: 12998
Ptprs
Name: protein tyrosine phosphatase receptor type S
Synonyms: PTP-NU3, Ptpt9, RPTPsigma, PTPsigma
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Copb2
Name: COPI coat complex subunit beta 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50797
HGNC: HGNC:2232
Homologene: 3499
Mtfr1
Name: mitochondrial fission regulator 1
Synonyms: 2810026O10Rik, 4930579E05Rik, 1300002C08Rik, Fam54a2, 1700080D04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67472
Homologene: 8763
Herpud2
Name: HERPUD family member 2
Synonyms: 5031400M07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80517
VEGA: 9
Homologene: 10756
Crtc1
Name: CREB regulated transcription coactivator 1
Synonyms: Mect1, TORC1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382056
Homologene: 41607
Serpind1
Name: serine (or cysteine) peptidase inhibitor, clade D, member 1
Synonyms: heparin cofactor II, Hcf2, HC II, HCII
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15160
HGNC: HGNC:4838
Homologene: 36018
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Zfp942
Name: zinc finger protein 942
Synonyms: 3110048L19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73233
Homologene: 133237
Ogfrl1
Name: opioid growth factor receptor-like 1
Synonyms: 2210417C17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70155
Homologene: 11595
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: 1700016D22Rik, F77
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Spata6
Name: spermatogenesis associated 6
Synonyms: KRP, Hash, 1700062C23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67946
Homologene: 10410
Bdh1
Name: 3-hydroxybutyrate dehydrogenase, type 1
Synonyms: Bdh, 2310032J20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71911
HGNC: HGNC:1027
Homologene: 20860
Tcaf1
Name: TRPM8 channel-associated factor 1
Synonyms: 3321401G04Rik, 2810407D09Rik, A230020K05Rik, Fam115a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77574
Homologene: 8815
Spart
Name: spartin
Synonyms: Spg20, TAHCCP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229285
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192166
Homologene: 5149
Tmem67
Name: transmembrane protein 67
Synonyms: b2b1163.1Clo, b2b1291.1Clo, 5330408M12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329795
Homologene: 71886
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: LOC380729, LOC268491, Gm1564
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268491
Homologene: 19559
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Suox
Name: sulfite oxidase
Synonyms: SO
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 211389
VEGA: 10
Homologene: 394
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm29096, Gm6976
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Ccdc115
Name: coiled-coil domain containing 115
Synonyms: 2310061I09Rik, Ccp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69668
Homologene: 13015
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21892
Homologene: 49202
Tgfbr3l
Name: transforming growth factor, beta receptor III-like
Synonyms: Gm14378, LOC100039590
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100044509
Homologene: 130375
Dagla
Name: diacylglycerol lipase, alpha
Synonyms: Nsddr
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 269060
HGNC: HGNC:1165
Homologene: 4468
Asah1
Name: N-acylsphingosine amidohydrolase 1
Synonyms: 2310081N20Rik, acid ceramidase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11886
HGNC: HGNC:735
Homologene: 10504
Gpr137c
Name: G protein-coupled receptor 137C
Synonyms: LOC380893, TM7SF1L2, 6330416L11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70713
Homologene: 28613
Pacc1
Name: proton activated chloride channel 1
Synonyms: 2310028N02Rik, Tmem206
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66950
Homologene: 10097
Mterf4
Name: mitochondrial transcription termination factor 4
Synonyms: 4933412H03Rik, 1810059A23Rik, Mterfd2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69821
Homologene: 45600
Ighg2b
Name: immunoglobulin heavy constant gamma 2B
Synonyms: gamma2b, IgG2b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16016
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 23,376,241 bp (GRCm38)
  • C to T, chromosome 1 at 34,438,849 bp (GRCm38)
  • T to C, chromosome 1 at 66,570,004 bp (GRCm38)
  • T to C, chromosome 1 at 93,301,466 bp (GRCm38)
  • T to C, chromosome 1 at 133,627,189 bp (GRCm38)
  • C to T, chromosome 1 at 191,344,977 bp (GRCm38)
  • T to A, chromosome 2 at 27,244,286 bp (GRCm38)
  • C to T, chromosome 2 at 76,788,224 bp (GRCm38)
  • T to C, chromosome 3 at 19,217,258 bp (GRCm38)
  • A to G, chromosome 3 at 53,007,301 bp (GRCm38)
  • T to A, chromosome 3 at 55,127,503 bp (GRCm38)
  • T to C, chromosome 3 at 63,784,006 bp (GRCm38)
  • C to A, chromosome 3 at 115,928,656 bp (GRCm38)
  • A to T, chromosome 4 at 12,045,814 bp (GRCm38)
  • G to T, chromosome 4 at 12,045,815 bp (GRCm38)
  • C to G, chromosome 4 at 111,828,329 bp (GRCm38)
  • T to A, chromosome 5 at 90,773,032 bp (GRCm38)
  • T to C, chromosome 6 at 42,678,749 bp (GRCm38)
  • A to G, chromosome 7 at 45,525,234 bp (GRCm38)
  • T to C, chromosome 7 at 118,145,753 bp (GRCm38)
  • G to A, chromosome 8 at 4,249,679 bp (GRCm38)
  • G to A, chromosome 8 at 41,374,547 bp (GRCm38)
  • T to C, chromosome 8 at 64,041,423 bp (GRCm38)
  • T to A, chromosome 8 at 70,439,465 bp (GRCm38)
  • A to G, chromosome 8 at 109,513,905 bp (GRCm38)
  • A to G, chromosome 9 at 25,130,640 bp (GRCm38)
  • T to C, chromosome 9 at 44,716,185 bp (GRCm38)
  • A to T, chromosome 9 at 98,585,930 bp (GRCm38)
  • T to A, chromosome 10 at 41,587,411 bp (GRCm38)
  • A to T, chromosome 10 at 100,568,851 bp (GRCm38)
  • A to G, chromosome 10 at 128,671,514 bp (GRCm38)
  • C to T, chromosome 11 at 35,698,328 bp (GRCm38)
  • C to T, chromosome 11 at 102,674,680 bp (GRCm38)
  • T to C, chromosome 12 at 100,935,734 bp (GRCm38)
  • C to T, chromosome 12 at 113,306,878 bp (GRCm38)
  • T to C, chromosome 14 at 45,278,730 bp (GRCm38)
  • A to G, chromosome 15 at 80,876,343 bp (GRCm38)
  • G to A, chromosome 16 at 17,339,774 bp (GRCm38)
  • A to G, chromosome 16 at 31,455,096 bp (GRCm38)
  • T to A, chromosome 17 at 21,929,033 bp (GRCm38)
  • C to T, chromosome 17 at 24,510,359 bp (GRCm38)
  • T to A, chromosome 17 at 45,673,179 bp (GRCm38)
  • T to C, chromosome 17 at 56,418,715 bp (GRCm38)
  • A to C, chromosome 19 at 10,251,065 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9539 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069338-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.