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Strain Name:
C57BL/6J-MtgxR9758Btlr/Mmmh
Stock Number:
070003-MU
Citation ID:
RRID:MMRRC_070003-MU
Other Names:
R9758 (G1)
Major Collection:

Strain Information

Drd1
Name: dopamine receptor D1
Synonyms: D1 receptor, Gpcr15, Drd-1, C030036C15Rik, Drd1a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13488
VEGA: 13
HGNC: HGNC:3020
Homologene: 30992
Creb1
Name: cAMP responsive element binding protein 1
Synonyms: Creb-1, Creb, 2310001E10Rik, 3526402H21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12912
HGNC: HGNC:2345
Homologene: 3223
Spmip11
Name: sperm microtubule inner protein 11
Synonyms: 4930415O20Rik, Tex49
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73863
VEGA: 15
Homologene: 19174
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Sec24d
Name: SEC24 homolog D, COPII coat complex component
Synonyms: 2310020L09Rik, LOC383951
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69608
Homologene: 40986
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Dhdds
Name: dehydrodolichyl diphosphate synthase
Synonyms: 3222401G21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67422
Homologene: 32615
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 37,042,357 bp (GRCm38)
  • A to T, chromosome 1 at 64,559,750 bp (GRCm38)
  • A to T, chromosome 1 at 75,557,675 bp (GRCm38)
  • C to T, chromosome 1 at 87,191,070 bp (GRCm38)
  • A to T, chromosome 1 at 92,452,030 bp (GRCm38)
  • G to A, chromosome 1 at 136,153,223 bp (GRCm38)
  • T to C, chromosome 1 at 155,894,687 bp (GRCm38)
  • A to G, chromosome 1 at 174,250,336 bp (GRCm38)
  • A to G, chromosome 2 at 87,252,095 bp (GRCm38)
  • A to G, chromosome 2 at 103,775,938 bp (GRCm38)
  • T to C, chromosome 2 at 114,049,318 bp (GRCm38)
  • A to C, chromosome 2 at 118,715,440 bp (GRCm38)
  • A to G, chromosome 2 at 130,713,018 bp (GRCm38)
  • C to T, chromosome 3 at 19,645,334 bp (GRCm38)
  • C to T, chromosome 3 at 123,343,154 bp (GRCm38)
  • A to G, chromosome 3 at 142,500,605 bp (GRCm38)
  • A to T, chromosome 3 at 154,253,685 bp (GRCm38)
  • A to G, chromosome 4 at 104,945,764 bp (GRCm38)
  • T to C, chromosome 4 at 134,000,395 bp (GRCm38)
  • A to G, chromosome 4 at 152,313,209 bp (GRCm38)
  • A to T, chromosome 5 at 3,635,876 bp (GRCm38)
  • T to A, chromosome 5 at 52,760,989 bp (GRCm38)
  • T to C, chromosome 5 at 65,302,048 bp (GRCm38)
  • G to T, chromosome 5 at 123,234,682 bp (GRCm38)
  • C to A, chromosome 5 at 146,483,818 bp (GRCm38)
  • A to G, chromosome 6 at 102,206,550 bp (GRCm38)
  • A to G, chromosome 6 at 124,191,678 bp (GRCm38)
  • A to G, chromosome 6 at 125,626,267 bp (GRCm38)
  • A to T, chromosome 6 at 143,038,887 bp (GRCm38)
  • G to T, chromosome 7 at 18,422,962 bp (GRCm38)
  • T to A, chromosome 7 at 18,430,677 bp (GRCm38)
  • T to C, chromosome 7 at 27,197,230 bp (GRCm38)
  • T to C, chromosome 7 at 27,347,017 bp (GRCm38)
  • A to G, chromosome 7 at 116,346,192 bp (GRCm38)
  • C to A, chromosome 7 at 139,920,704 bp (GRCm38)
  • A to G, chromosome 8 at 105,142,422 bp (GRCm38)
  • G to A, chromosome 9 at 23,375,606 bp (GRCm38)
  • A to T, chromosome 9 at 26,889,598 bp (GRCm38)
  • A to G, chromosome 9 at 107,585,148 bp (GRCm38)
  • A to T, chromosome 9 at 109,449,101 bp (GRCm38)
  • A to G, chromosome 9 at 115,960,451 bp (GRCm38)
  • A to G, chromosome 10 at 80,277,606 bp (GRCm38)
  • G to A, chromosome 10 at 120,038,664 bp (GRCm38)
  • T to A, chromosome 11 at 67,058,424 bp (GRCm38)
  • A to T, chromosome 12 at 111,299,349 bp (GRCm38)
  • T to A, chromosome 12 at 113,329,632 bp (GRCm38)
  • C to A, chromosome 13 at 27,709,277 bp (GRCm38)
  • A to G, chromosome 13 at 54,053,163 bp (GRCm38)
  • C to T, chromosome 13 at 61,356,409 bp (GRCm38)
  • GCA to GCAACA, chromosome 13 at 117,975,769 bp (GRCm38)
  • T to C, chromosome 14 at 31,263,438 bp (GRCm38)
  • G to A, chromosome 15 at 71,452,350 bp (GRCm38)
  • T to C, chromosome 15 at 75,973,569 bp (GRCm38)
  • T to A, chromosome 15 at 98,585,383 bp (GRCm38)
  • C to T, chromosome 16 at 88,729,341 bp (GRCm38)
  • T to A, chromosome 17 at 21,433,887 bp (GRCm38)
  • A to T, chromosome 17 at 26,213,653 bp (GRCm38)
  • G to A, chromosome 17 at 35,528,388 bp (GRCm38)
  • T to A, chromosome 17 at 57,107,355 bp (GRCm38)
  • T to A, chromosome 18 at 32,083,294 bp (GRCm38)
  • T to C, chromosome 18 at 37,448,987 bp (GRCm38)
  • T to A, chromosome 18 at 56,478,900 bp (GRCm38)
  • T to C, chromosome 18 at 80,449,495 bp (GRCm38)
  • A to T, chromosome 19 at 24,900,306 bp (GRCm38)
  • G to A, chromosome 19 at 44,569,939 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9758 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
070003-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.