Strain Detail Sheet

Strain Name:
C57BL/6J-Tap2m2Btlr/Mmmh
Stock Number:
038153--TBD-
Citation ID:
RRID:MMRRC_038153--TBD-
Other Names:
date
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Tap2m2Btlr
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); mutation 2, Bruce Beutler
Synonyms: date
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
Tap2
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: Ham2, Ham-2, PSF2, MTP2, HAM2, Tap-2, Abcb3
Type: Gene
Species: Mouse
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 21355
HGNC: HGNC:44
Homologene: 37323
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Genetic Alterations
ENU-induced T to A transversion at base pair 34,212,354 (v38) on chromosome 17, or base pair 8,270 in the GenBank genomic region NC_000083 for the Tap2 gene. The mutation corresponds to residue 1,418 in the mRNA sequence NM_011530 within exon 7 of 12 total exons. The mutation results in a valine (V) to aspartic acid (D) substitution at position 422 (V422D) in the Tap2 protein.

Strain Description

Phenotype

Homozygous: Mice showed showed an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of CD8+ T cells and CD8+ T cells in CD3+ T cells with a concomitant increase in the CD4+ T cell frequency in CD3+ T cells, all in the peripheral blood. An increase in the CD44+ mean fluorescence intensity on CD8+ T cells was also observed.

Heterozygous: No signficant abnormal phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
  • hematopoietic system
    • increased CD4-positive, alpha beta T cell number [MP:0008074]
    • decreased CD8-positive, alpha-beta T cell number [MP:0008079]
  • immune system
    • increased CD4-positive, alpha beta T cell number [MP:0008074]
    • decreased CD8-positive, alpha-beta T cell number [MP:0008079]
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Immunology and Inflammation

Strain Origin

Primary Reference

Choi JH, Wang K-W, Zeng M, Murray AR, Beutler B. Record for date. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

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