Strain Detail Sheet

Strain Name:
C57BL/6J-Irf7M2Btlr/Mmmh
Stock Number:
038163--TBD-
Citation ID:
RRID:MMRRC_038163--TBD-
Other Names:
Houstonian
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Irf7M2Btlr
Name: interferon regulatory factor 7; mutation 2, Bruce Beutler
Synonyms: Houstonian
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Irf7
Name: interferon regulatory factor 7
Type: Gene
Species: Mouse
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 54123
HGNC: HGNC:6122
Homologene: 128624
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Genetic Alterations
ENU-induced A to G transition at base pair 141,264,022 (v38) on chromosome 7, or base pair 2,478 in the GenBank genomic region NC_000073 for the Irf7 gene. The mutation corresponds to residue 1,179 in the mRNA sequence NM_016850 within exon 8 of 10 total exons. The mutation results in a threonine (T) to alanine (A) substitution at position 246 (T246A) in the IRF7 protein.

Strain Description

Phenotype

Homozygous: Mice showed reduced type I interferon (IFN) production by macrophages after stimulation with double stranded (ds) DNA.

Heterozygous: Mice showed reduced type I interferon (IFN) production by macrophages after stimulation with double stranded (ds) DNA; the heterozygote phenotype is variable.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
  • homeostasis/metabolism
    • decreased circulating interferon-beta level [MP:0008576]
  • immune system
    • decreased circulating interferon-beta level [MP:0008576]
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Immunology and Inflammation

Strain Origin

Primary Reference

Dao D, Shi H, Zhang Z, Wang Y, Sun L, Wang J, Murray AR, Beutler B. Record for Houstonian. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

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