Strain Detail Sheet

Strain Name:
C57BL/6J-Cd22m3Btlr/Mmmh
Stock Number:
038179--TBD-
Citation ID:
RRID:MMRRC_038179--TBD-
Other Names:
yosemite
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Cd22m3Btlr
Name: CD22 antigen; mtutaion 3, Bruce Beutler
Synonyms: yosemite
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Cd22
Name: CD22 antigen
Synonyms: Lyb8, Lyb-8
Type: Gene
Species: Mouse
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12483
HGNC: HGNC:1643
Homologene: 31052
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Genetic Alterations
ENU-induced G to T transversion at base pair 30,869,509 (v38) on chromosome 7, or base pair 10,834 in the GenBank genomic region NC_000073 for the Cd22 gene within the donor splice site of intron 9. The mutation is predicted to result in an in-frame skipping of the 264-nucleotide exon 9 (out of 14 total exons), which encodes amino acids 612-699. The effect of the mutation at the cDNA and protein level has not been tested.

Strain Description

Phenotype

Homozygous: Mice exhibit decrease in the frequency of B cells (Figure 1), an increased frequency of B1a cells in B1 cells as well as a reduced frequency of IgM+ B cells and a decrease in the percentage of IgD+ B cells, all in the peripheral blood.

Heterozygous: No signficant abnormal phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Immunology and Inflammation

Strain Origin

Primary Reference

Choi JH, Zeng M, Wang K-W, Murray AR, Beutler B. Record for yosemite. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

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