Strain Detail Sheet

Strain Name:
C57BL/6J-Malt1m3Btlr/Mmmh
Stock Number:
038221--TBD-
Citation ID:
RRID:MMRRC_038221--TBD-
Other Names:
bryce_canyon
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Malt1m3Btlr
Name: MALT1 paracaspase; mutation 3, Bruce Beutler
Synonyms: bryce_canyon
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
Malt1
Name: MALT1 paracaspase
Synonyms: paracaspase, D430033E09Rik, Pcasp1
Type: Gene
Species: Mouse
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240354
HGNC: HGNC:6819
Homologene: 4938
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Genetic Alterations
ENU-induced T to C transition at base pair 65,462,915 (v38) on chromosome 18, or base pair 31,947 in the GenBank genomic region NC_000084 for the Malt1 gene, within the donor splice site of intron 10 (2 base pairs from exon 10). The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in skipping of the 178-base pair exon 10 (out of 16 total exons), resulting in a frame-shift and coding of 13 aberrant amino acids followed by a premature stop codon within exon 11 (after amino acid 418).

Strain Description

Phenotype

Homozygous: Mice showed diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-β-galactosidase (rSFV-β-gal). The T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) was also diminished.

Heterozygous: The T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) was diminished to intermediate levels between wild-type and homozygous bryce_canyon mice.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Immunology and Inflammation

Strain Origin

Primary Reference

Wang K-W, Choi JH, Murray AR, Beutler B. Record for bryce_canyon. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

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