Strain Detail Sheet

Strain Name:
C57BL/6J-Tyrc-2Btlr/Mmmh
Stock Number:
038249--TBD-
Citation ID:
RRID:MMRRC_038249--TBD-
Other Names:
pale_rider
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Tyrc-2Btlr
Name: tyrosinase; albino 2 Bruce Beutler
Synonyms: Tyrm2Btlr, pale rider
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Tyr
Name: tyrosinase
Synonyms: Oca1, skc35
Type: Gene
Species: Mouse
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22173
Homologene: 30969
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Additional Resources
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Genetic Alterations
ENU-induced T to A transversion was found at position 1341 of the Tyr transcript in exon 4 of 5 total exons (94586533 bp NCBI Mouse Genome Build 37.1, Chromosome 7). The mutation causes a valine to aspartic acid substitution at residue 427 of tyrosinase.

Strain Description

Phenotype

Homozygous: Mice exhibit albinism with white fur and red eyes.

Heterozygous: No abnormal phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Cell Biology
  • Dermatology
  • Models for Human Disease
    • Oculocutaneous albinism 1A (OCA1A, OMIM #203100)
    • Oculocutaneous albinism 1B (OCA1B, OMIM #606952)

Strain Origin

Primary Reference

Arnold CN, Pirie E, Smart NG, Beutler B. Record for pale_rider. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.