Strain Name:
C57BL/6J-MtgxR0622Btlr/Mmmh
Stock Number:
038811-MU
Citation ID:
RRID:MMRRC_038811-MU
Other Names:
R0622 (G1), C57BL/6J-MtgxR0622Btlr
Major Collection:

Strain Information

Itpk1
Name: inositol 1,3,4-triphosphate 5/6 kinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217837
HGNC: HGNC:6177
Homologene: 8588
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Ctage5
Name: CTAGE family, member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Ptcd2
Name: pentatricopeptide repeat domain 2
Synonyms: 1190005P08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68927
VEGA: 13
Homologene: 11695
Dhdds
Name: dehydrodolichyl diphosphate synthase
Synonyms: 3222401G21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67422
Homologene: 32615
Tnks
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms: D130072O21Rik, Parp5a, 4930554K12Rik, mTNKS1, TANK1, tankyrase 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21951
Homologene: 18405
Proser1
Name: proline and serine rich 1
Synonyms: 2810046L04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 212127
Homologene: 13463
Zeb1
Name: zinc finger E-box binding homeobox 1
Synonyms: Tw, Zfhx1a, Zfx1a, Zfhep, Tcf18, MEB1, Nil2, 3110032K11Rik, Tcf8, AREB6, ZEB, [delta]EF1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21417
Homologene: 31779
Exosc4
Name: exosome component 4
Synonyms: 1110039I09Rik, 1500001N04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109075
Homologene: 6017
Mrps5
Name: mitochondrial ribosomal protein S5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77721
Homologene: 32726
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: D330037A14Rik, LL5A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102693
Homologene: 15903
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: Gpr1g, E130018M02Rik, mGluR7, mGlu7a receptor, 6330570A01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Rfx2
Name: regulatory factor X, 2 (influences HLA class II expression)
Synonyms: 5430432H19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19725
VEGA: 17
HGNC: HGNC:9983
Homologene: 30980
Dsg4
Name: desmoglein 4
Synonyms: CDHF13, lah
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16769
Homologene: 65341
Nfix
Name: nuclear factor I/X
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18032
HGNC: HGNC:7788
Homologene: 1872
St8sia5
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Synonyms: Siat8e, ST8SiaV
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225742
Homologene: 8331
Pdia4
Name: protein disulfide isomerase associated 4
Synonyms: Cai, U48620, ERp72, Erp72
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12304
Homologene: 21020
Ap1b1
Name: adaptor protein complex AP-1, beta 1 subunit
Synonyms: b2b1660Clo, Adtb1, beta-prime adaptin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11764
HGNC: HGNC:554
Homologene: 21972
Lrch1
Name: leucine-rich repeats and calponin homology (CH) domain containing 1
Synonyms: 4832412D13Rik, Chdc1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380916
VEGA: 14
Homologene: 32244
Wasf3
Name: WASP family, member 3
Synonyms: Wave3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 245880
Homologene: 68527
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Agtr1a
Name: angiotensin II receptor, type 1a
Synonyms: AT1a, AT1, Agtr1a, Agtr-1a, Agt1ar, 1810074K20Rik, Angtr-1a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11607
HGNC: HGNC:336
Homologene: 3556
Trim9
Name: tripartite motif-containing 9
Synonyms: C030048G07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94090
VEGA: 12
Homologene: 9045
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, mKIAA0811, LOC245827, Fath2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Zdhhc25
Name: zinc finger, DHHC domain containing 25
Synonyms: 1700030J15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70073
Homologene: 19298
Ralgps1
Name: Ral GEF with PH domain and SH3 binding motif 1
Synonyms: RALGPS1A, RALGEF2, 5830418G11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241308
Homologene: 65163
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
F3
Name: coagulation factor III
Synonyms: tissue factor, TF, CD142, Cf3, Cf-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14066
HGNC: HGNC:3541
Homologene: 1511
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: C030033M19Rik, RIM1alpha, RIM1, RIM1a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116837
Homologene: 128399
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Gramd4
Name: GRAM domain containing 4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223752
Homologene: 18199
Or6z5
Name: olfactory receptor family 6 subfamily Z member 5
Synonyms: MOR103-6, Olfr1346, GA_x6K02T2QGBW-3203957-3204898
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258918
Homologene: 74134
Or8c20
Name: olfactory receptor family 8 subfamily C member 20
Synonyms: MOR170-3, Olfr898, GA_x6K02T2PVTD-32037624-32038565
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258871
VEGA: 9
Homologene: 133654
Nlrc3
Name: NLR family, CARD domain containing 3
Synonyms: Caterpiller 16.2, D230007K08Rik, CLR16.2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268857
Homologene: 18720
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Synonyms: p110alpha, caPI3K, 6330412C24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18706
HGNC: HGNC:8975
Homologene: 21249
Gys1
Name: glycogen synthase 1, muscle
Synonyms: Gys3, MGS
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14936
HGNC: HGNC:4706
Homologene: 113557
Cpb1
Name: carboxypeptidase B1
Synonyms: 1810063F02Rik, 0910001A18Rik, 2210008M23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76703
HGNC: HGNC:2299
Homologene: 68127
Sla2
Name: Src-like-adaptor 2
Synonyms: SLAP2, A930009E21Rik, SLAP-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77799
Homologene: 49989
Wdr90
Name: WD repeat domain 90
Synonyms: 3230401M21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106618
Homologene: 27066
Kcnh7
Name: potassium voltage-gated channel, subfamily H (eag-related), member 7
Synonyms: Kv11.3, erg3, 9330137I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170738
Homologene: 13249
Or2t44
Name: olfactory receptor family 2 subfamily T member 44
Synonyms: GA_x6K02T2NKPP-622179-621244, Olfr314, MOR278-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257917
Homologene: 133891
Or52ad1
Name: olfactory receptor family 52 subfamily AD member 1
Synonyms: GA_x6K02T2PBJ9-6056235-6055291, Olfr600, MOR39-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259048
Homologene: 17476
Myrf
Name: myelin regulatory factor
Synonyms: LOC225908, Gm98, LOC386531
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225908
HGNC: HGNC:1181
Homologene: 32167
Stom
Name: stomatin
Synonyms: Epb7.2, stomatin, protein 7.2b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13830
HGNC: HGNC:3383
Homologene: 81681
Klhl29
Name: kelch-like 29
Synonyms: A230106N14Rik, Kbtbd9
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208439
VEGA: 12
Homologene: 66272
Pou2f3
Name: POU domain, class 2, transcription factor 3
Synonyms: Skin, Skn-li, Epoc-1, Otf-11, Skin-1a, Otf11, Oct11, Oct-11a, Skn-1a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18988
Homologene: 7898
Prkag2
Name: protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Synonyms: 2410051C13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108099
HGNC: HGNC:9386
Homologene: 136125
Vmn1r77
Name: vomeronasal 1 receptor 77
Synonyms: Gm6935
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628946
Homologene: 103843
Cd163
Name: CD163 antigen
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93671
HGNC: HGNC:1631
Homologene: 128811
Stk32c
Name: serine/threonine kinase 32C
Synonyms: YANK3, Pkek
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57740
Homologene: 75157
Sh2d5
Name: SH2 domain containing 5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230863
Homologene: 20002
Nanp
Name: N-acetylneuraminic acid phosphatase
Synonyms: Hdhd4, 1600031M04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67311
Homologene: 12112
Pramel29
Name: PRAME like 29
Synonyms: C87977
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 97187
Homologene: 103830
Slc17a2
Name: solute carrier family 17 (sodium phosphate), member 2
Synonyms: NPT3, C730032N17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218103
Homologene: 4260
Mcpt4
Name: mast cell protease 4
Synonyms: Mcp-4, MMCP-4B, MMCP-4A, MMCP-4, myonase, Mcp4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17227
VEGA: 14
Homologene: 130645
Ccdc152
Name: coiled-coil domain containing 152
Synonyms: ENSMUSG00000071814
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 100039139
VEGA: 15
Homologene: 79247
Zfp677
Name: zinc finger protein 677
Synonyms: A830058L05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210503
Homologene: 138402
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 22,538,275 bp
  • C to A, chromosome 1 at 45,384,467 bp
  • G to A, chromosome 2 at 33,174,447 bp
  • A to T, chromosome 2 at 35,336,851 bp
  • A to G, chromosome 2 at 41,728,551 bp
  • T to C, chromosome 2 at 52,212,951 bp
  • A to C, chromosome 2 at 62,837,289 bp
  • A to G, chromosome 2 at 112,662,555 bp
  • T to C, chromosome 2 at 125,379,024 bp
  • A to G, chromosome 2 at 127,594,531 bp
  • A to G, chromosome 2 at 151,039,244 bp
  • A to G, chromosome 2 at 156,883,583 bp
  • C to A, chromosome 3 at 20,249,818 bp
  • A to G, chromosome 3 at 32,436,552 bp
  • A to G, chromosome 3 at 53,477,860 bp
  • G to A, chromosome 3 at 90,167,740 bp
  • A to T, chromosome 3 at 121,725,019 bp
  • G to C, chromosome 4 at 133,994,236 bp
  • T to C, chromosome 4 at 138,259,228 bp
  • T to C, chromosome 4 at 144,213,013 bp
  • T to C, chromosome 5 at 24,869,249 bp
  • A to G, chromosome 5 at 121,348,625 bp
  • A to G, chromosome 5 at 146,466,792 bp
  • A to T, chromosome 6 at 47,806,518 bp
  • G to A, chromosome 6 at 111,358,496 bp
  • G to A, chromosome 6 at 124,317,352 bp
  • T to C, chromosome 7 at 6,474,599 bp
  • T to G, chromosome 7 at 12,041,388 bp
  • A to T, chromosome 7 at 45,439,995 bp
  • A to G, chromosome 7 at 103,346,857 bp
  • T to A, chromosome 7 at 105,763,449 bp
  • T to C, chromosome 7 at 139,188,110 bp
  • A to G, chromosome 8 at 34,940,822 bp
  • A to C, chromosome 8 at 84,726,482 bp
  • A to G, chromosome 9 at 38,349,371 bp
  • C to T, chromosome 9 at 43,125,119 bp
  • T to C, chromosome 9 at 44,715,852 bp
  • G to T, chromosome 9 at 105,925,852 bp
  • A to G, chromosome 11 at 5,037,707 bp
  • A to T, chromosome 11 at 55,283,128 bp
  • T to C, chromosome 11 at 58,786,341 bp
  • A to G, chromosome 12 at 5,081,224 bp
  • C to T, chromosome 12 at 59,131,578 bp
  • A to G, chromosome 12 at 70,346,604 bp
  • G to T, chromosome 12 at 102,573,980 bp
  • C to A, chromosome 13 at 23,812,611 bp
  • T to A, chromosome 13 at 30,381,681 bp
  • T to C, chromosome 13 at 99,343,307 bp
  • C to A, chromosome 14 at 56,060,662 bp
  • T to C, chromosome 14 at 74,796,051 bp
  • T to C, chromosome 15 at 3,298,178 bp
  • A to G, chromosome 15 at 76,327,536 bp
  • T to A, chromosome 15 at 86,091,389 bp
  • T to C, chromosome 15 at 88,601,107 bp
  • C to T, chromosome 16 at 3,953,968 bp
  • T to C, chromosome 16 at 37,060,993 bp
  • C to T, chromosome 17 at 21,397,700 bp
  • C to T, chromosome 17 at 25,855,658 bp
  • T to A, chromosome 17 at 34,718,729 bp
  • T to C, chromosome 17 at 56,777,071 bp
  • C to T, chromosome 18 at 5,759,123 bp
  • T to A, chromosome 18 at 20,449,788 bp
  • A to G, chromosome 18 at 77,246,113 bp
  • G to A, chromosome 19 at 10,223,452 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0622 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038811-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.