Strain Name:
C57BL/6J-MtgxR0720Btlr/Mmmh
Stock Number:
038902-MU
Citation ID:
RRID:MMRRC_038902-MU
Other Names:
R0720 (G1), C57BL/6J-MtgxR0720Btlr
Major Collection:

Strain Information

Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd1, Edd
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Eri3
Name: exoribonuclease 3
Synonyms: PINT1, Prnpip1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 140546
Homologene: 15403
Sec23a
Name: SEC23 homolog A, COPII coat complex component
Synonyms: Sec23r, Msec23
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20334
Homologene: 4642
Mllt10
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms: Af10, D630001B22Rik, B130021D15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17354
Homologene: 20973
Fxr2
Name: FMR1 autosomal homolog 2
Synonyms: Fxr2h
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23879
HGNC: HGNC:4024
Homologene: 21014
Gas2l3
Name: growth arrest-specific 2 like 3
Synonyms: LOC237436, 8430435B07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237436
VEGA: 10
Homologene: 18386
Hipk2
Name: homeodomain interacting protein kinase 2
Synonyms: Stank, 1110014O20Rik, B230339E18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15258
Homologene: 68766
Rhot1
Name: ras homolog family member T1
Synonyms: Miro1, 2210403N23Rik, FLJ11040, Arht1, C430039G08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 59040
Homologene: 56803
Lrrc47
Name: leucine rich repeat containing 47
Synonyms: 2900010D03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72946
Homologene: 10795
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: D030073L15Rik, 2310076G09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237782
Homologene: 16989
Tdo2
Name: tryptophan 2,3-dioxygenase
Synonyms: TDO, TO, chky
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56720
Homologene: 4132
Ptger2
Name: prostaglandin E receptor 2 (subtype EP2)
Synonyms: EP2, Ptgerep2, EP2 receptor
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19217
HGNC: HGNC:9594
Homologene: 739
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Mdnah5, b2b1154Clo, b2b1134Clo, b2b1537Clo, b2b1565Clo, Dnahc5, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Bbs7
Name: Bardet-Biedl syndrome 7
Synonyms: 8430406N16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71492
Homologene: 12395
Taar1
Name: trace amine-associated receptor 1
Synonyms: Tar1, Trar1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 111174
VEGA: 10
Homologene: 24938
Nlrp14
Name: NLR family, pyrin domain containing 14
Synonyms: 4921520L01Rik, Nalp14, GC-LRR, Nalp-iota
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76858
Homologene: 18531
Dynap
Name: dynactin associated protein
Synonyms: 2310002L13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75577
VEGA: 18
Homologene: 82463
Rmdn2
Name: regulator of microtubule dynamics 2
Synonyms: Fam82a1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381110
VEGA: 17
Homologene: 71930
Kansl1l
Name: KAT8 regulatory NSL complex subunit 1-like
Synonyms: C430010P07Rik, 1110028C15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68691
Homologene: 27376
Or1e34
Name: olfactory receptor family 1 subfamily E member 34
Synonyms: GA_x6K02T2P1NL-4043306-4042374, MOR135-8, Olfr394
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259009
Homologene: 133669
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, 1110018I21Rik, E030018G17Rik, Tns, E030037J05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Or5w20
Name: olfactory receptor family 5 subfamily W member 20
Synonyms: GA_x6K02T2Q125-49395950-49396882, MOR177-7, Olfr1153
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258633
Homologene: 27230
Cyp3a57
Name: cytochrome P450, family 3, subfamily a, polypeptide 57
Synonyms: EG622127
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622127
Homologene: 135775
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Great, LGR8, Gpr106
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140498
Homologene: 15402
Tnfsf18
Name: tumor necrosis factor (ligand) superfamily, member 18
Synonyms: Gitrl, GITR ligand
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240873
Homologene: 3732
Vmn2r99
Name: vomeronasal 2, receptor 99
Synonyms: EG665376
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665376
Homologene: 115024
Spag6l
Name: sperm associated antigen 6-like
Synonyms: PF16, Spag6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50525
Homologene: 8252
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR3, VEGFR-3, Flt-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Htra3
Name: HtrA serine peptidase 3
Synonyms: 9530081K03Rik, 2210021K23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78558
Homologene: 12697
Adgrf2
Name: adhesion G protein-coupled receptor F2
Synonyms: PGR20, Gpr111
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 435529
Homologene: 45213
Txndc8
Name: thioredoxin domain containing 8
Synonyms: 4930429J24Rik, Sptrx3, Sptrx-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67402
Homologene: 41663
Entrep2
Name: endosomal transmembrane epsin interactor 2
Synonyms: 5730507A09Rik, Fam189a1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70638
Homologene: 77705
Zdhhc2
Name: zinc finger, DHHC domain containing 2
Synonyms: 6430583A19Rik, 5730415P04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70546
Homologene: 81667
Fbxo25
Name: F-box protein 25
Synonyms: Fbx25, 9130015I06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66822
Homologene: 41649
Commd4
Name: COMM domain containing 4
Synonyms: 1110039H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66199
VEGA: 9
Homologene: 9865
Gcm1
Name: glial cells missing homolog 1
Synonyms: glial cell deficient, glide, Gcm a, Gcm 1, Gcm1-rs1, GCMa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14531
VEGA: 9
HGNC: HGNC:4197
Homologene: 2702
Gm17143
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 66,801,356 bp
  • A to G, chromosome 1 at 73,925,581 bp
  • A to G, chromosome 1 at 161,503,587 bp
  • T to C, chromosome 2 at 18,196,595 bp
  • A to T, chromosome 2 at 87,896,669 bp
  • T to C, chromosome 3 at 36,592,423 bp
  • G to T, chromosome 3 at 81,962,758 bp
  • C to T, chromosome 4 at 57,984,245 bp
  • T to C, chromosome 4 at 117,553,045 bp
  • A to T, chromosome 4 at 123,432,925 bp
  • T to C, chromosome 4 at 154,019,887 bp
  • T to C, chromosome 5 at 35,654,109 bp
  • T to C, chromosome 5 at 145,390,403 bp
  • G to T, chromosome 5 at 150,044,119 bp
  • C to T, chromosome 6 at 38,698,556 bp
  • A to G, chromosome 7 at 64,819,910 bp
  • A to G, chromosome 7 at 107,182,013 bp
  • A to G, chromosome 8 at 13,935,222 bp
  • T to A, chromosome 8 at 40,472,907 bp
  • G to T, chromosome 9 at 57,155,434 bp
  • A to T, chromosome 9 at 78,064,641 bp
  • T to C, chromosome 10 at 23,921,073 bp
  • T to C, chromosome 10 at 89,413,943 bp
  • C to T, chromosome 11 at 49,636,339 bp
  • T to C, chromosome 11 at 60,778,443 bp
  • A to G, chromosome 11 at 69,639,415 bp
  • T to A, chromosome 11 at 73,887,862 bp
  • T to C, chromosome 11 at 80,223,943 bp
  • G to A, chromosome 12 at 58,971,271 bp
  • C to A, chromosome 14 at 4,442,719 bp
  • T to C, chromosome 14 at 44,989,133 bp
  • A to G, chromosome 15 at 28,313,861 bp
  • T to C, chromosome 15 at 37,972,991 bp
  • A to T, chromosome 16 at 16,767,096 bp
  • T to A, chromosome 17 at 19,379,043 bp
  • A to G, chromosome 17 at 42,713,172 bp
  • G to A, chromosome 17 at 79,668,029 bp
  • T to C, chromosome 18 at 70,240,984 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0720 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038902-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.