Strain Name:
C57BL/6J-MtgxR4640Btlr/Mmmh
Stock Number:
041902-MU
Citation ID:
RRID:MMRRC_041902-MU
Other Names:
R4640 (G1), C57BL/6J-MtgxR4640Btlr
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: PTPzeta, DSD-1-PG, phosphacan, RPTPz, Ptprz, Ptpz, Rptpbeta, PTPbeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Cnmd
Name: chondromodulin
Synonyms: Bricd3, ChM-I, Chmd, Lect1, Chondromodulin 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16840
Homologene: 5095
Kera
Name: keratocan
Synonyms: CNA2, SLRR2B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16545
VEGA: 10
HGNC: HGNC:6309
Homologene: 5106
Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 2310047O13Rik, Fam188a, 1810041E18Rik, 5830410F13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66960
Homologene: 11478
Ndufv1
Name: NADH:ubiquinone oxidoreductase core subunit V1
Synonyms: 24 kDa (FP)
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17995
HGNC: HGNC:7716
Homologene: 5151
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 52184
Homologene: 12011
Srpk1
Name: serine/arginine-rich protein specific kinase 1
Synonyms: SR protein-specific kinase 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20815
Homologene: 110962
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: Sra-1, l(7)1Rl, P140SRA-1, E030028J09Rik, Shyc, pl-1, l7Rl1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20430
Homologene: 22628
Tmem104
Name: transmembrane protein 104
Synonyms: C630005D06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320534
Homologene: 9802
R3hdm1
Name: R3H domain containing 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226412
HGNC: HGNC:9757
Homologene: 9108
Ctdp1
Name: CTD phosphatase subunit 1
Synonyms: 4930563P03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67655
HGNC: HGNC:2498
Homologene: 31254
Cct4
Name: chaperonin containing TCP1 subunit 4
Synonyms: T complex protein 1, delta, TCP-1 delta, A45, 2610204B21Rik, Cctd
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12464
HGNC: HGNC:1617
Homologene: 4695
Mcm2
Name: minichromosome maintenance complex component 2
Synonyms: Mcmd2, BM28, CDCL1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17216
HGNC: HGNC:6944
Homologene: 3325
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232491
Homologene: 11758
Ubxn11
Name: UBX domain protein 11
Synonyms: 4930506L07Rik, Soci, Ubxd5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67586
Homologene: 12159
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: EGF-TM7 receptor, 1110033N21Rik, Etl, Eltd1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170757
Homologene: 11170
Mns1
Name: meiosis-specific nuclear structural protein 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17427
Homologene: 40628
Ano4
Name: anoctamin 4
Synonyms: A330096O15Rik, Tmem16d
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320091
Homologene: 66599
Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif 16
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271127
Homologene: 15146
Cfap251
Name: cilia and flagella associated protein 251
Synonyms: 4933428F06Rik, 4930415N18Rik, Wdr66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269701
Homologene: 16964
Nrxn1
Name: neurexin I
Synonyms: alpha-latrotoxin receptor (calcium-dependent), 1700062G21Rik, neurexin I alpha, 9330127H16Rik, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I beta, A230068P09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Cyp2c37
Name: cytochrome P450, family 2. subfamily c, polypeptide 37
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13096
Homologene: 137231
Lipo2
Name: lipase, member O2
Synonyms: Gm8981
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 101055671
Homologene: 103863
Fam124b
Name: family with sequence similarity 124, member B
Synonyms: A830043J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241128
Homologene: 65263
Foxe3
Name: forkhead box E3
Synonyms: rct, FREAC8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30923
HGNC: HGNC:3808
Homologene: 32145
Dytn
Name: dystrotelin
Synonyms: LOC241073
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241073
Homologene: 104042
Phxr2
Name: per-hexamer repeat gene 2
Synonyms: SP28
Type: Gene
Species: Mouse
Chromosome: 10
Or13g1
Name: olfactory receptor family 13 subfamily G member 1
Synonyms: MOR251-4P, GA_x6K02T2NHDJ-9801340-9802266, Olfr309
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258196
Homologene: 47595
Gm5884
Name: predicted pseudogene 5884
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545878
Plcxd3
Name: phosphatidylinositol-specific phospholipase C, X domain containing 3
Synonyms: B130016O10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239318
Homologene: 45574
Nlrp4g
Name: NLR family, pyrin domain containing 4G
Synonyms: nalp4g, Gm47182, Gm47180
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235779
VEGA: 9
Gm15350
Name: predicted gene 15350
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100504249
Sall2
Name: spalt like transcription factor 2
Synonyms: Msal-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50524
Homologene: 9269
Lipf
Name: lipase, gastric
Synonyms: 2310051B21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67717
HGNC: HGNC:6622
Homologene: 68139
Or2d3c
Name: olfactory receptor family 2 subfamily D member 3C
Synonyms: GA_x6K02T2PBJ9-9307730-9306814, Olfr709, MOR260-7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258146
Copz2
Name: coatomer protein complex, subunit zeta 2
Synonyms: zeta2-COP, nonclathrin coat protein zeta2-COP, 1110012D12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56358
Homologene: 69215
Ppp1r27
Name: protein phosphatase 1, regulatory subunit 27
Synonyms: toonin, Dysfip1, 1110033I14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68701
Homologene: 45933
Fam115e
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 63,643,348 bp
  • G to A, chromosome 1 at 80,213,526 bp
  • T to C, chromosome 1 at 128,175,238 bp
  • T to C, chromosome 2 at 12,348,163 bp
  • G to A, chromosome 3 at 145,128,945 bp
  • T to C, chromosome 3 at 151,500,310 bp
  • G to A, chromosome 4 at 114,925,775 bp
  • G to A, chromosome 4 at 134,125,109 bp
  • G to T, chromosome 5 at 123,302,432 bp
  • A to G, chromosome 6 at 22,972,798 bp
  • A to G, chromosome 6 at 42,587,579 bp
  • A to T, chromosome 6 at 88,887,804 bp
  • A to G, chromosome 6 at 128,645,771 bp
  • C to G, chromosome 6 at 142,354,741 bp
  • C to T, chromosome 7 at 55,913,451 bp
  • T to A, chromosome 7 at 86,307,066 bp
  • T to C, chromosome 7 at 106,926,593 bp
  • A to G, chromosome 8 at 12,828,434 bp
  • A to G, chromosome 9 at 72,439,282 bp
  • T to C, chromosome 9 at 124,349,153 bp
  • C to T, chromosome 10 at 88,954,697 bp
  • A to T, chromosome 10 at 97,612,887 bp
  • T to C, chromosome 10 at 99,126,069 bp
  • T to A, chromosome 11 at 23,002,297 bp
  • A to T, chromosome 11 at 96,856,707 bp
  • T to A, chromosome 11 at 115,243,724 bp
  • T to C, chromosome 11 at 120,550,727 bp
  • G to A, chromosome 13 at 70,779,518 bp
  • T to A, chromosome 14 at 52,315,159 bp
  • T to C, chromosome 14 at 79,656,653 bp
  • T to C, chromosome 15 at 4,517,243 bp
  • T to C, chromosome 17 at 28,608,724 bp
  • A to G, chromosome 17 at 90,560,768 bp
  • C to A, chromosome 18 at 80,451,154 bp
  • A to G, chromosome 19 at 4,008,469 bp
  • T to C, chromosome 19 at 33,720,837 bp
  • A to T, chromosome 19 at 33,968,797 bp
  • A to T, chromosome 19 at 40,011,832 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4640 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041902-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.