Strain Name:
C57BL/6J-MtgxR5623Btlr/Mmmh
Stock Number:
043162-MU
Citation ID:
RRID:MMRRC_043162-MU
Other Names:
R5623 (G1), C57BL/6J-MtgxR5623Btlr
Major Collection:

Strain Information

Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Eif4a2
Name: eukaryotic translation initiation factor 4A2
Synonyms: 4833432N07Rik, BM-010, Eif4, Ddx2b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13682
HGNC: HGNC:3284
Homologene: 1487
B3gnt2
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Synonyms: B3Galt6, B3gnt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53625
Homologene: 4797
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Rab1a
Name: RAB1A, member RAS oncogene family
Synonyms: Gtbp, Rab-1, Ypt1, ras-related YPT1 protein, Rab1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19324
HGNC: HGNC:9758
Homologene: 36154
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Diaph1
Name: diaphanous related formin 1
Synonyms: mDia1, p140mDia, D18Wsu154e, Drf1, Diap1, Dia1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13367
HGNC: HGNC:2876
Homologene: 129567
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Ptprg
Name: protein tyrosine phosphatase receptor type G
Synonyms: 5430405N12Rik, RPTPgamma
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Sspn
Name: sarcospan
Synonyms: Krag
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16651
Homologene: 3727
Clec16a
Name: C-type lectin domain family 16, member A
Synonyms: 4932416N17Rik, curt
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74374
Homologene: 71019
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: RIM2, Syt3-rs, 2810036I15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 116838
VEGA: 15
Homologene: 81639
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, C330019G07Rik, Prl14l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215476
Homologene: 65866
Inpp5j
Name: inositol polyphosphate 5-phosphatase J
Synonyms: Pib5pa, Pipp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170835
HGNC: HGNC:8956
Homologene: 8682
Tpcn2
Name: two pore segment channel 2
Synonyms: D830047E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233979
Homologene: 16375
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: TRPC7, Trrp7, 9830168K16Rik, LTRPC2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28240
Homologene: 20709
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: E030034C22Rik, Dnahc1, G1-415-19, MDHC7, ferf1, B230373P09Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: Ic, FIC1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Skic2
Name: SKI2 subunit of superkiller complex
Synonyms: Ski2w, 4930534J06Rik, Skiv2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 108077
Homologene: 123971
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408066
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
G6pc2
Name: glucose-6-phosphatase, catalytic, 2
Synonyms: IGRP, islet specific glucose-6-phosphatase, G6pc-rs
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14378
Homologene: 41423
Ephb6
Name: Eph receptor B6
Synonyms: Mep, Cekl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Tdrd6
Name: tudor domain containing 6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210510
Homologene: 19364
Dis3l
Name: DIS3 like exosome 3'-5' exoribonuclease
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 213550
Homologene: 15797
Mdm1
Name: MDM1 nuclear protein
Synonyms: Mdm-1, transformed mouse 3T3 cell double minute 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17245
VEGA: 10
Homologene: 9692
Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: A730039N16Rik, D030049F17Rik, Nedl2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329152
Homologene: 66192
Ccdc13
Name: coiled-coil domain containing 13
Synonyms: 2900041A11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100502861
Homologene: 87213
Psg21
Name: pregnancy-specific beta-1-glycoprotein 21
Synonyms: cea8, 1600019C01Rik, 1600026N13Rik, 1600025N01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72242
Homologene: 110989
Klk1b21
Name: kallikrein 1-related peptidase b21
Synonyms: mGk-21, Klk21
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16616
Homologene: 68141
Chrm3
Name: cholinergic receptor, muscarinic 3, cardiac
Synonyms: Chrm-3, muscarinic acetylcholine receptor 3, M3R
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12671
HGNC: HGNC:1952
Homologene: 20191
Strip1
Name: striatin interacting protein 1
Synonyms: 6530401O14Rik, Fam40a, 6330569M22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229707
Homologene: 35064
Gm10717
Name: predicted gene 10717
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Rnf215
Name: ring finger protein 215
Synonyms: 0610009J22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71673
Homologene: 12402
Cfap221
Name: cilia and flagella associated protein 221
Synonyms: Gm101, Pcdp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226356
Homologene: 88578
Gpcpd1
Name: glycerophosphocholine phosphodiesterase 1
Synonyms: 2310032D16Rik, Prei4, 2310004G06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74182
Homologene: 10478
Slc34a3
Name: solute carrier family 34 (sodium phosphate), member 3
Synonyms: NPTIIc, Npt2c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 142681
Homologene: 15444
Tmem132b
Name: transmembrane protein 132B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208151
Homologene: 28135
Or5k8
Name: olfactory receptor family 5 subfamily K member 8
Synonyms: Olfr174, GA_x54KRFPKG5P-55026345-55025418, GA_x54KRFPKG5P-54993816-54992890, MOR184-1, Olfr175-ps1, MOR184-10P, Olfr175
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259004
Homologene: 17461
Nfu1
Name: NFU1 iron-sulfur cluster scaffold
Synonyms: CGI-33, 0610006G17Rik, Hirip5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56748
Homologene: 6369
Trem1
Name: triggering receptor expressed on myeloid cells 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58217
Homologene: 10243
Kat5
Name: K(lysine) acetyltransferase 5
Synonyms: mHTATIP/CPLA2, Htatip, Tip60, PLIP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 81601
VEGA: 19
HGNC: HGNC:5275
Homologene: 100661
Tmprss11e
Name: transmembrane protease, serine 11e
Synonyms: DESC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243084
Homologene: 8543
Cnksr3
Name: Cnksr family member 3
Synonyms: Magi1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215748
Homologene: 18192
Gpr153
Name: G protein-coupled receptor 153
Synonyms: 1110065N12Rik, PGR1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100129
Homologene: 18662
Or6c206
Name: olfactory receptor family 6 subfamily C member 206
Synonyms: MOR111-12, GA_x6K02T2PULF-10947193-10948131, Olfr776
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 404321
Homologene: 115559
Tmem176b
Name: transmembrane protein 176B
Synonyms: Clast1, 1810009M01Rik, Lr8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 65963
Homologene: 8521
Gm5414
Name: predicted gene 5414
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 406223
VEGA: 15
Fgf18
Name: fibroblast growth factor 18
Synonyms: D130055P09Rik, FGF-18
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14172
HGNC: HGNC:3674
Homologene: 2867
Sult5a1
Name: sulfotransferase family 5A, member 1
Synonyms: Sultx1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 57429
Homologene: 129532
Spmip8
Name: sperm microtubule inner protein 8
Synonyms: 1700055M20Rik, Tepp
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73407
Homologene: 28311
Ighv14-3
Name: immunoglobulin heavy variable V14-3
Synonyms: Gm16840
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238418
Tmppe
Name: transmembrane protein with metallophosphoesterase domain
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100504715
VEGA: 9
Homologene: 62675
Gm6195
Name: predicted pseudogene 6195
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108167613
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 9,802,295 bp
  • T to C, chromosome 1 at 34,190,133 bp
  • T to A, chromosome 1 at 53,832,623 bp
  • C to T, chromosome 1 at 119,954,168 bp
  • T to A, chromosome 2 at 25,233,300 bp
  • A to G, chromosome 2 at 69,226,583 bp
  • G to T, chromosome 2 at 132,534,717 bp
  • T to C, chromosome 3 at 107,626,826 bp
  • T to C, chromosome 4 at 58,091,964 bp
  • A to G, chromosome 4 at 152,281,941 bp
  • A to T, chromosome 5 at 32,844,508 bp
  • G to A, chromosome 5 at 86,709,456 bp
  • G to A, chromosome 5 at 125,623,352 bp
  • T to A, chromosome 6 at 41,616,481 bp
  • T to G, chromosome 6 at 48,834,070 bp
  • TCGC to T, chromosome 6 at 87,016,206 bp
  • T to A, chromosome 6 at 145,961,226 bp
  • A to C, chromosome 7 at 18,655,014 bp
  • A to G, chromosome 7 at 44,105,565 bp
  • T to C, chromosome 7 at 105,772,769 bp
  • T to A, chromosome 7 at 145,267,334 bp
  • T to A, chromosome 8 at 85,843,048 bp
  • A to G, chromosome 8 at 95,325,571 bp
  • A to T, chromosome 8 at 109,623,719 bp
  • A to C, chromosome 8 at 123,157,442 bp
  • C to T, chromosome 9 at 3,026,318 bp
  • A to C, chromosome 9 at 55,864,507 bp
  • A to G, chromosome 9 at 64,307,603 bp
  • C to A, chromosome 9 at 114,405,896 bp
  • T to C, chromosome 9 at 121,833,733 bp
  • T to A, chromosome 10 at 7,120,548 bp
  • C to A, chromosome 10 at 77,932,139 bp
  • G to A, chromosome 10 at 118,150,789 bp
  • G to A, chromosome 10 at 129,261,032 bp
  • C to A, chromosome 11 at 3,494,766 bp
  • T to G, chromosome 11 at 4,135,453 bp
  • T to C, chromosome 11 at 20,201,626 bp
  • C to G, chromosome 11 at 22,837,018 bp
  • T to G, chromosome 11 at 33,134,272 bp
  • A to C, chromosome 12 at 114,060,090 bp
  • C to A, chromosome 13 at 9,877,387 bp
  • T to C, chromosome 13 at 113,346,634 bp
  • T to A, chromosome 14 at 12,153,857 bp
  • G to T, chromosome 14 at 31,286,023 bp
  • A to T, chromosome 15 at 39,478,615 bp
  • A to G, chromosome 15 at 101,625,811 bp
  • T to A, chromosome 16 at 10,611,121 bp
  • C to T, chromosome 16 at 23,110,219 bp
  • C to T, chromosome 16 at 58,824,343 bp
  • T to A, chromosome 17 at 15,754,932 bp
  • T to C, chromosome 17 at 34,847,432 bp
  • T to C, chromosome 17 at 43,629,333 bp
  • C to T, chromosome 17 at 48,237,055 bp
  • T to G, chromosome 17 at 74,528,656 bp
  • C to T, chromosome 17 at 84,191,983 bp
  • A to T, chromosome 18 at 37,896,093 bp
  • T to G, chromosome 18 at 64,546,094 bp
  • G to A, chromosome 19 at 5,607,562 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5623 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043162-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.