Strain Name:
C57BL/6J-MtgxR6366Btlr/Mmmh
Stock Number:
044516-MU
Citation ID:
RRID:MMRRC_044516-MU
Other Names:
R6366 (G1)
Major Collection:

Strain Information

Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alphaII-spectrin, 2610027H02Rik, Spna-2, Spna2, alpha-fodrin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Spag7
Name: sperm associated antigen 7
Synonyms: Fsa1l, FSA-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216873
Homologene: 3595
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Slc7a7
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
Synonyms: my+lat1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20540
Homologene: 88701
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100929
Homologene: 7068
Fbxo42
Name: F-box protein 42
Synonyms: 6720460I06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 213499
Homologene: 16234
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, 2900054D09Rik, Ankyrin-3, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Unc5b
Name: unc-5 netrin receptor B
Synonyms: 6330415E02Rik, D10Bwg0792e, Unc5h2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 107449
VEGA: 10
Homologene: 32538
Boc
Name: BOC cell adhesion associated, oncogene regulated
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 117606
Homologene: 32819
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: 4432404A22Rik, Snf2p
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Wtap
Name: WT1 associating protein
Synonyms: 9430038B09Rik, 2810408K05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 60532
Homologene: 68422
Stk38
Name: serine/threonine kinase 38
Synonyms: 5830476G13Rik, 9530097A09Rik, Ndr1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106504
Homologene: 56033
Podn
Name: podocan
Synonyms: SLRR5A
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242608
Homologene: 17803
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: Cxxc8, Fbxl11, Jhdm1a, Fbl7, lalina, 5530401A10Rik, Gm4560
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225876
Homologene: 56564
Hspa1a
Name: heat shock protein 1A
Synonyms: Hsp70a1, Hsp68, Hsp70-3, Hsp70.3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193740
Homologene: 74294
Samd4
Name: sterile alpha motif domain containing 4
Synonyms: Smaug, 4933436G17Rik, sunk, 1700111L17Rik, 1700024G08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74480
Homologene: 19167
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTPL1, PTP-BL, Ptpri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 9630046L06Rik, 9430004C13Rik, 1110061O17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Plb1
Name: phospholipase B1
Synonyms: 4632413E21Rik, 4930433E17Rik, 4930539A06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665270
Homologene: 82108
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212392
Homologene: 17668
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74711
Homologene: 41769
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192187
Homologene: 9035
Chl1
Name: cell adhesion molecule L1-like
Synonyms: A530023M13Rik, close homolog of L1, LICAM2, CALL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12661
HGNC: HGNC:1939
Homologene: 21314
Tyro3
Name: TYRO3 protein tyrosine kinase 3
Synonyms: Brt, Sky, Tif, Sky, Etk-2, Dtk, Rse
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22174
Homologene: 4585
Shcbp1
Name: Shc SH2-domain binding protein 1
Synonyms: mPAL
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20419
Homologene: 32123
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Tectb
Name: tectorin beta
Synonyms: Tctnb, [b]-tectorin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21684
Homologene: 7568
Sh3rf2
Name: SH3 domain containing ring finger 2
Synonyms: 9130023G24Rik, RNF158
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269016
Homologene: 17618
Pde6a
Name: phosphodiesterase 6A, cGMP-specific, rod, alpha
Synonyms: Pdea
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225600
HGNC: HGNC:8785
Homologene: 380
Gys2
Name: glycogen synthase 2
Synonyms: LGS, glycogen synthase, liver
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232493
HGNC: HGNC:4707
Homologene: 56580
Ltv1
Name: LTV1 ribosome biogenesis factor
Synonyms: 2610020N02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353258
VEGA: 10
Homologene: 6338
Nacad
Name: NAC alpha domain containing
Synonyms: mKIAA0363
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192950
Homologene: 135717
Spata31e4
Name: spermatogenesis associated 31 subfamily E member 4
Synonyms: Gm8765
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 667693
Homologene: 134512
Ms4a1
Name: membrane-spanning 4-domains, subfamily A, member 1
Synonyms: Cd20, Ly-44
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12482
HGNC: HGNC:7315
Homologene: 7259
Redic1
Name: regulator of DNA class I crossover intermediates 1
Synonyms: CN725425, Gm5807
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545126
Lrtm2
Name: leucine-rich repeats and transmembrane domains 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211187
Homologene: 65244
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: 4930517G15Rik, 4930540C21Rik, Ccdc7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74703
Homologene: 134760
Mgat4d
Name: MGAT4 family, member C
Synonyms: 4933434I20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67555
Homologene: 128538
Etfb
Name: electron transferring flavoprotein, beta polypeptide
Synonyms: 2810441H06Rik, 0610009I16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110826
HGNC: HGNC:3482
Homologene: 1503
Potefam1
Name: POTE ankyrin domain family member 1
Synonyms: Potea, Pote1, A26c3, 4930430A15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67575
Homologene: 69410
Mknk2
Name: MAP kinase-interacting serine/threonine kinase 2
Synonyms: Mnk2, 2010016G11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17347
HGNC: HGNC:7111
Homologene: 49674
Eif4a1
Name: eukaryotic translation initiation factor 4A1
Synonyms: Eif4, initiation factor eIF-4A long form
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13681
HGNC: HGNC:3282
Homologene: 103998
Prl3b1
Name: prolactin family 3, subfamily b, member 1
Synonyms: PL, Pl-2, Csh2, mplII, prolactin-like, mPL-II, Pl2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18776
Homologene: 7476
Lpxn
Name: leupaxin
Synonyms: 4933402K05Rik, A530083L21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107321
VEGA: 19
Homologene: 3536
Lhx1
Name: LIM homeobox protein 1
Synonyms: Lim1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16869
HGNC: HGNC:6593
Homologene: 4068
Rpl37
Name: ribosomal protein L37
Synonyms: 3110005M08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67281
VEGA: 15
Homologene: 68110
Mup12
Name: major urinary protein 12
Synonyms: Gm2024
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039054
Homologene: 74304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 30,020,455 bp
  • A to G, chromosome 2 at 111,169,592 bp
  • G to A, chromosome 2 at 119,816,675 bp
  • G to T, chromosome 2 at 152,991,605 bp
  • A to G, chromosome 3 at 97,594,160 bp
  • A to G, chromosome 3 at 116,791,117 bp
  • T to C, chromosome 3 at 158,135,375 bp
  • A to C, chromosome 4 at 60,740,658 bp
  • T to A, chromosome 4 at 88,628,865 bp
  • T to A, chromosome 4 at 108,018,804 bp
  • A to G, chromosome 4 at 128,483,452 bp
  • T to A, chromosome 4 at 141,199,949 bp
  • A to G, chromosome 5 at 32,314,085 bp
  • G to T, chromosome 5 at 103,551,053 bp
  • T to C, chromosome 5 at 130,281,951 bp
  • C to A, chromosome 6 at 103,729,236 bp
  • T to C, chromosome 6 at 119,317,277 bp
  • C to A, chromosome 6 at 142,463,394 bp
  • T to C, chromosome 7 at 43,452,941 bp
  • A to G, chromosome 8 at 4,749,380 bp
  • A to G, chromosome 8 at 45,943,388 bp
  • T to A, chromosome 8 at 83,368,951 bp
  • A to G, chromosome 8 at 128,855,992 bp
  • T to C, chromosome 9 at 18,646,044 bp
  • A to G, chromosome 10 at 13,180,995 bp
  • C to T, chromosome 10 at 60,778,312 bp
  • A to G, chromosome 10 at 69,999,358 bp
  • A to T, chromosome 10 at 76,710,970 bp
  • C to A, chromosome 10 at 80,671,933 bp
  • A to C, chromosome 11 at 6,601,196 bp
  • G to T, chromosome 11 at 69,670,955 bp
  • T to C, chromosome 11 at 70,664,592 bp
  • A to T, chromosome 11 at 84,522,208 bp
  • A to T, chromosome 13 at 27,243,892 bp
  • T to C, chromosome 13 at 50,701,936 bp
  • T to C, chromosome 14 at 31,141,438 bp
  • T to A, chromosome 14 at 47,074,150 bp
  • T to C, chromosome 14 at 54,374,600 bp
  • T to A, chromosome 15 at 5,118,508 bp
  • T to G, chromosome 15 at 91,246,921 bp
  • T to C, chromosome 16 at 44,487,652 bp
  • A to T, chromosome 17 at 12,968,058 bp
  • A to G, chromosome 17 at 28,974,364 bp
  • G to A, chromosome 17 at 34,970,524 bp
  • G to T, chromosome 18 at 12,482,137 bp
  • T to C, chromosome 18 at 42,153,065 bp
  • T to A, chromosome 18 at 61,265,071 bp
  • G to T, chromosome 19 at 4,324,932 bp
  • A to G, chromosome 19 at 11,258,698 bp
  • G to A, chromosome 19 at 12,824,799 bp
  • G to A, chromosome 19 at 55,181,918 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6366 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044516-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.